TLX1 - T cell leukemia homeobox 1 Gene

Homo sapiens

Also known as TCL3; HOX11

Gene ID: 3195 | Gene type: protein coding

About TLX1

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:101,131,300-101,137,789 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues, 42 paralogues and is associated with 46 phenotypes. Biased expression in spleen (RPKM 14.4) and salivary gland (RPKM 3.2).

Summary

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

TLX1 Products(2)

mRNA	Protein	Name
NM_001195517.2	NP_001182446.1	T-cell leukemia homeobox protein 1 isoform 2
NM_005521.4	NP_005512.1	T-cell leukemia homeobox protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19559479	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLX1 Protein Structure

Homeobox

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

T-cell leukemia homeobox protein 1

T-cell leukemia/lymphoma protein 3

TLX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TLX1	P31314	MEIS1	Homo sapiens	O00470	Y2H	19559479
Intra	TLX1	P31314	MEIS1	Homo sapiens	O00470	Anti Tag CoIP	19559479
Intra	TLX1	P31314	PBX2	Homo sapiens	P40425	Affinity Chrom	35140242
Cross	TLX1	P31314	Ets1	Mus musculus	P27577	Pull Down	22516263
Intra	TLX1	P31314	PBX1	Homo sapiens	P40424-2	Anti Tag CoIP	19559479
Intra	TLX1	P31314	PBX1	Homo sapiens	P40424-2	Y2H	19559479

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Childhood Acute Lymphocytic Leukemia

Childhood Acute Lymphoblastic Leukemia	Childhood All
Pediatric Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia Acute Childhood

Epilepsy, Familial Temporal Lobe, 4

ETL4	Epilepsy, Occipitotemporal Lobe, And Migraine With Aura
Epolm	Familial Temporal Lobe Epilepsy 4
Occipitotemporal Lobe Epilepsy And Migraine With Aura

B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1

B-All With Etv6-Runx1	B-Lymphoblastic Leukemia/Lymphoma With T(12
21)(P13.2	Q22.1)
Etv6-Runx1	B Lymphoblastic Leukemia/Lymphoma With T(12
21)(P13.2	Q22.1)
Etv6-Runx1

Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia	Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia
T-Cell Childhood Acute Lymphocytic Leukemia	Childhood T Lymphoblastic Leukemia/Lymphoma

Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All

Split Hand-Foot Malformation

Ectrodactyly	Split-Hand/Foot Malformation
Lobster-Claw Deformity	Split-Hand Deformity
Split Hand Foot Malformation	Shfm
Split Hand Foot Deformity	Split Hand Foot Deformity 1

Right Atrial Isomerism

Ivemark Syndrome	Asplenia With Cardiovascular Anomalies
RAI	Asplenia Syndrome
Asplenia	Right Isomerism
Splenic Agenesis Syndrome	Bilateral Right-Sidedness Sequence
Right Sided Atrial Isomerism	Isomerism Of Right Atrial Appendage
Heterotaxy, Visceroatrial, Autosomal Recessive	Polyasplenia
Vah, Autosomal Recessive	Atrial Isomerism, Right
Congenital Absence Of Spleen	Bilateral Right-Sidedness

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14602	TLX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TLX1	MGD	MGI:98769
Rattus norvegicus	TLX1	RGD	RGD:1563655

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