2. Gene
  3. ACACB - acetyl-CoA carboxylase beta Gene

ACACB - acetyl-CoA carboxylase beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta

Gene ID: 32 | Gene type: protein coding

About ACACB

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,111,189-109,268,226 (from NCBI)

This gene has 15 transcripts (splice variants), 207 orthologues and 4 paralogues. Biased expression in fat (RPKM 94.8), liver (RPKM 8.9) and 6 other tissues.

Summary

Acetyl-CoA Carboxylase (ACC) is a complex multifunctional Enzyme system. ACC is a biotin-containing Enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]

ACACB Products(9)

mRNA Protein Name
NM_001093.4 NP_001084.3 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412734.1 NP_001399663.1 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412735.1 NP_001399664.1 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412736.1 NP_001399665.1 acetyl-CoA carboxylase 2 isoform b
NM_001412737.1 NP_001399666.1 acetyl-CoA carboxylase 2 isoform c
NM_001412738.1 NP_001399667.1 acetyl-CoA carboxylase 2 isoform d
NM_001412739.1 NP_001399668.1 acetyl-CoA carboxylase 2 isoform e
NM_001412741.1 NP_001399670.1 acetyl-CoA carboxylase 2 isoform f
NM_001412742.1 NP_001399671.1 acetyl-CoA carboxylase 2 isoform g
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetyl-CoA carboxylase activity IDA
IDA: Inferred from direct assay
19236960 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20457939 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16794074 GOA
Biological Process GO Annotation Evidence Reference Source
involved in acetyl-CoA metabolic process IDA
IDA: Inferred from direct assay
20952656 GOA
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
20952656 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
10677481 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10677481 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACACB Protein Structure

Biotin_carb_N

Biotin_carb_N: Biotin carboxylase, N-terminal domain (260 - 379)

CPSase_L_D2

CPSase_L_D2: Carbamoyl-phosphate synthase L chain, ATP binding domain (431 - 614)

Biotin_carb_C

Biotin_carb_C: Biotin carboxylase C-terminal domain (651 - 757)

Biotin_lipoyl

Biotin_lipoyl: Biotin-requiring enzyme (897 - 961)

ACC_central

ACC_central: Acetyl-CoA carboxylase, central region (962 - 1688)

Carboxyl_trans

Carboxyl_trans: Carboxyl transferase domain (1780 - 2333)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2458 a.a.
Protein Preferred Names Protein Names

acetyl-CoA carboxylase 2

acetyl-Coenzyme A carboxylase beta

ACACB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ACACB O00763 GSK3A Homo sapiens P49840
Anti Tag CoIP
33961781
Intra
ACACB O00763 TACC1 Homo sapiens O75410
Anti Tag CoIP
33961781
Intra
ACACB O00763 ACACA Homo sapiens Q13085
Anti Tag CoIP
33961781
Intra
ACACB O00763 HMGA1 Homo sapiens P17096
Crosslink
30021884
Intra
ACACB O00763 IDS Homo sapiens P22304
Anti Tag CoIP
33961781
Intra
ACACB O00763 GSK3B Homo sapiens P49841
Anti Tag CoIP
33961781
Intra
ACACB O00763 PRKAA1 Homo sapiens Q13131
Anti Tag CoIP
33961781
Intra
ACACB O00763 GRK7 Homo sapiens Q8WTQ7
Anti Tag CoIP
33961781
Intra
ACACB O00763 MID1IP1 Homo sapiens Q9NPA3
Anti Tag CoIP
33961781
Intra
ACACB O00763 ACACB Homo sapiens O00763
GMS
20457939
Intra
ACACB O00763 ACAA1 Homo sapiens P09110
Anti Tag CoIP
33961781
Intra
ACACB O00763 MRPL46 Homo sapiens Q9H2W6
Anti Tag CoIP
33961781
Intra
ACACB O00763 ACACB Homo sapiens O00763
Comig Non-Denat Gel
20457939
Cross: Cross-species interaction Intra: Intraspecies interaction

ACACB Antibodies

Cat. No. Product Name Application Reactivity
HY-P80528 Acetyl Coenzyme A Carboxylase Antibody WB, IHC-F, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Biotin Deficiency

Biotin Deficiency Disease

B7 Deficiency

Biotan Vitamin Deficiency
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00122 ACACB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACACB MGD MGI:2140940
Bos taurus ACACB VGNC VGNC:25520
Macaca mulatta ACACB VGNC VGNC:99876
Felis catus ACACB VGNC VGNC:68655
Rattus norvegicus ACACB RGD RGD:620500
Canis familiaris ACACB VGNC VGNC:37490