HOXA3 - homeobox A3 Gene

Homo sapiens

Also known as HOX1; HOX1E

Gene ID: 3200 | Gene type: protein coding

About HOXA3

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:27,107,010-27,152,583 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 42 paralogues. Broad expression in kidney (RPKM 1.8), fat (RPKM 1.4) and 17 other tissues.

Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HOXA3 Products(14)

mRNA	Protein	Name
NM_001384335.1	NP_001371264.1	homeobox protein Hox-A3
NM_001384336.1	NP_001371265.1	homeobox protein Hox-A3
NM_001384337.1	NP_001371266.1	homeobox protein Hox-A3
NM_001384338.1	NP_001371267.1	homeobox protein Hox-A3
NM_001384339.1	NP_001371268.1	homeobox protein Hox-A3
NM_001384340.1	NP_001371269.1	homeobox protein Hox-A3
NM_001384341.1	NP_001371270.1	homeobox protein Hox-A3
NM_001384342.1	NP_001371271.1	homeobox protein Hox-A3
NM_001384343.1	NP_001371272.1	homeobox protein Hox-A3
NM_001384344.1	NP_001371273.1	homeobox protein Hox-A3
NM_001384345.1	NP_001371274.1	homeobox protein Hox-A3
NM_001384346.1	NP_001371275.1	homeobox protein Hox-A3
NM_030661.5	NP_109377.1	homeobox protein Hox-A3
NM_153631.3	NP_705895.1	homeobox protein Hox-A3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IEP IEP: Inferred from expression pattern	17972163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXA3 Protein Structure

Homeobox

DUF4074

0
100
200
300
400
443 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-A3

Hox-1.5-like protein

HOXA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOXA3	O43365	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	HOXA3	O43365	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	HOXA3	O43365	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	HOXA3	O43365	ARPC3	Homo sapiens	O15145	Validated Y2H	25416956
Intra	HOXA3	O43365	ARPC3	Homo sapiens	O15145	Y2H Array	25416956
Intra	HOXA3	O43365	SEC23B	Homo sapiens	Q15437	Y2H	21516116
Intra	HOXA3	O43365	SEC23B	Homo sapiens	Q15437	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Penile Cancer

Penis Carcinoma	Carcinoma Of Penis
Penile Neoplasm	Penile Carcinoma
Penile Neoplasms	Malignant Neoplasm Of Penis
Ca Penis	Malignant Neoplasm Of Body Of Penis
Malignant Penile Tumor	Penile Ca

T-Cell Immunodeficiency With Thymic Aplasia

Nezelof Syndrome	T-Lymphocyte Deficiency
TIDTA	Immune Defect Due To Absence Of Thymus
Thymic Aplasia	Nezelof'S Syndrome
Thymic Dysplasia With Normal Immunoglobulins	Thymic Aplasia Syndrome
T-Lymphocyte Immunodeficiency

Ectopic Thymus

Thyroid Malformation

Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome	Hfgs
Hfg Syndrome	Hfu Syndrome
HFG	Hfu
Hand Foot Uterus Syndrome	Hand Foot Genital Syndrome

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06298	HOXA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HOXA3	VGNC	VGNC:73502
Felis catus	HOXA3	VGNC	VGNC:67619
Mus musculus	HOXA3	MGD	MGI:96175
Rattus norvegicus	HOXA3	RGD	RGD:1561431
Bos taurus	HOXA3	VGNC	VGNC:29911
Canis familiaris	HOXA3	VGNC	VGNC:41747

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