FOXN2 - forkhead box N2 Gene

Homo sapiens

Also known as HTLF

Gene ID: 3344 | Gene type: protein coding

About FOXN2

Cytogenetic location: 2p16.3 Genomic coordinates (GRCh38): 2:48,313,659-48,379,295 (from NCBI)

This gene has 2 transcripts (splice variants), 217 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 14.2), fat (RPKM 8.5) and 24 other tissues.

Summary

This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

FOXN2 Products(13)

mRNA	Protein	Name
NM_001375442.1	NP_001362371.1	forkhead box protein N2 isoform a
NM_001375443.1	NP_001362372.1	forkhead box protein N2 isoform a
NM_001375444.1	NP_001362373.1	forkhead box protein N2 isoform a
NM_001375445.1	NP_001362374.1	forkhead box protein N2 isoform a
NM_001375446.1	NP_001362375.1	forkhead box protein N2 isoform a
NM_001375447.1	NP_001362376.1	forkhead box protein N2 isoform a
NM_001375448.1	NP_001362377.1	forkhead box protein N2 isoform a
NM_001375449.1	NP_001362378.1	forkhead box protein N2 isoform a
NM_001375450.1	NP_001362379.1	forkhead box protein N2 isoform a
NM_001375451.1	NP_001362380.1	forkhead box protein N2 isoform a
NM_001375452.1	NP_001362381.1	forkhead box protein N2 isoform a
NM_001375781.1	NP_001362710.1	forkhead box protein N2 isoform b
NM_002158.4	NP_002149.2	forkhead box protein N2 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25609649	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXN2 Protein Structure

Forkhead

0
100
200
300
400
431 a.a.

Protein Preferred Names

Protein Names

forkhead box protein N2

human T-cell leukemia virus enhancer factor

FOXN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXN2	P32314	FBXW11	Homo sapiens	Q9UKB1	TAP	25609649
Intra	FOXN2	P32314	FBXW11	Homo sapiens	Q9UKB1	Anti Tag CoIP	33961781
Intra	FOXN2	P32314	RFX1	Homo sapiens	P22670	Pull Down	25609649
Intra	FOXN2	P32314	RFX1	Homo sapiens	P22670	Anti Tag CoIP	33961781
Intra	FOXN2	P32314	RFX1	Homo sapiens	P22670	Anti Tag CoIP	28514442
Intra	FOXN2	P32314	RFX1	Homo sapiens	P22670	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05066	FOXN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FOXN2	VGNC	VGNC:29096
Mus musculus	FOXN2	MGD	MGI:1347478
Canis familiaris	FOXN2	VGNC	VGNC:40961
Felis catus	FOXN2	VGNC	VGNC:80104
Macaca mulatta	FOXN2	VGNC	VGNC:72710
Rattus norvegicus	FOXN2	RGD	RGD:1562291

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