IAPP - islet amyloid polypeptide Gene

Homo sapiens

Also known as DAP; IAP

Gene ID: 3375 | Gene type: protein coding

About IAPP

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,354,959-21,379,980 (from NCBI)

This gene has 5 transcripts (splice variants), 171 orthologues and 2 paralogues. Restricted expression toward pancreas (RPKM 16.6).

Summary

This gene encodes a member of the Calcitonin family of peptide Hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]

IAPP Products(2)

mRNA	Protein	Name
NM_000415.3	NP_000406.1	islet amyloid polypeptide preproprotein
NM_001329201.2	NP_001316130.1	islet amyloid polypeptide preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	22944668	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17640888	GOA
enables lipid binding	EXP EXP: Inferred from Experiment	32077246	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17051221	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	22500019	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	22500019	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in amylin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in amyloid fibril formation	IDA IDA: Inferred from direct assay	22944668	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	22944668	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of cAMP/PKA signal transduction	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of calcium-mediated signaling	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	22500019	GOA
involved in protein destabilization	IDA IDA: Inferred from direct assay	22944668	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	22944668	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in inclusion body	IDA IDA: Inferred from direct assay	22944668	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IAPP Protein Structure

Calc_CGRP_IAPP

0
89 a.a.

Protein Preferred Names

Protein Names

islet amyloid polypeptide

Islet amyloid polypeptide (diabetes-associated peptide

IAPP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IAPP	P10997	BACE2	Homo sapiens	Q9Y5Z0	Protease Assay	26840340
Intra	IAPP	P10997	BACE1	Homo sapiens	P56817	Protease Assay	26840340
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	TEM	17640888
Intra	IAPP	P10997	TRIP6	Homo sapiens	Q15654	Anti Tag CoIP	33961781
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	3D-EM	18408164
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	Aggregation	26840340
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	X-Ray Fiber Diffrac	17640888
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	AFM	24561193
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	3D-EM	32541895
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	Fluorescence	24561193
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	Fluorescence	24042052
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	Fluorescence Spectr	18408164
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	DLS	24561193
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	TEM	24561193
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	GMS	21130765
Intra	IAPP	P10997	IAPP	Homo sapiens	P10997	TEM	18408164

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IAPP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72240	IAPP Protein, Human (GST)	P10997 (K34-Y70)	≥95%

Related Diseases

Diseases

Alias

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Hyperglycemia

Islet Cell Tumor

Pancreatic Neuroendocrine Tumor	Neuroendocrine Tumor Of Pancreas
Pnet	Pancreatic Net
Pancreatic Endocrine Tumor	Well-Differentiated Nen Of Pancreas
Well-Differentiated Neuroendocrine Neoplasm Of Pancreas	Well-Differentiated Pancreatic Nen
Well-Differentiated Pancreatic Neuroendocrine Neoplasm	Endocrine Pancreas Cancer
Islet Cell Neoplasm	Islet Cell Tumour
Malignant Pancreatic Endocrine Tumor	Malignant Pancreatic Endocrine Tumour
Malignant Tumor Of Endocrine Pancreas	Malignant Tumour Of Endocrine Pancreas
Pancreatic Endocrine Neoplasm	Pancreatic Neuroendocrine Neoplasm
Adenoma, Islet Cell	Well Differentiated Pancreatic Endocrine Tumor
Malignant Neoplasm Of Endocrine Pancreas	Pancreatic Endocrine Carcinoma

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Prediabetes Syndrome

Prediabetes	Impaired Glucose Tolerance
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Dialysis-Related Amyloidosis

Abeta2m Amyloidosis	Amyloidosis Beta2m
Beta2-Microglobulinic Amyloidosis	Variant Abeta2m Amyloidosis
Autosomal Dominant Beta2-Microglobulinic Amyloidosis	Aβ2m Amyloidosis
Dialysis-Related Beta2-Microglobulin Amyloidosis	Amyloidosis Dialysis-Related
Beta-2-Microglobulin Amyloidosis	Dra
Hemodialysis-Associated Amyloidosis

Gestational Diabetes

Gestational Diabetes Mellitus	GDM
Diabetes Mellitus Arising In Pregnancy	Maternal Gestational Diabetes Mellitus
Diabetes Mellitus, Gestational	Diabetes Mellitus, Pregnancy Related
Diabetes, Pregnancy-Induced	Diabetes Gestational
Diabetes, Gestational	Diabetes Of Pregnancy
Gdm - [Gestational Diabetes Mellitus]	Gestational Diabetes Mellitus Nos
Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium

Diabetes Mellitus

Diabetes

Wild-Type Amyloidosis

Senile Systemic Amyloidosis	Attrwt Amyloidosis
Age Related Amyloidosis	Old Age Amyloidosis
Wild-Type Attr Amyloidosis	Wild-Type Transthyretin Cardiac Amyloidosis
Wild Type Attr Amyloidosis	Attrwt-Related Amyloidosis
Wild Type Attr-Related Amyloidosis

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis	German Type Amyloidosis
Familial Renal Amyloidosis	Amyloidosis Viii
Amyloidosis, 3 Or More Types	Familial Visceral Amyloidosis
Familial Amyloid Nephropathy	Hereditary Amyloid Nephropathy
Amyloidosis, Familial Renal	Amyloidosis, Systemic Nonneuropathic
Amyloidosis Familial Visceral	Amyloidosis 8
Amyloidosis, Ostertag Type	Hereditary Amyloidosis With Primary Renal Involvement
Hereditary Renal Amyloidosis	Renal Amyloidosis
Amyloidosis, Renal	Systemic Nonneuropathic Amyloidosis
Amyloidosis Familial Renal	Amyloidosis Systemic Nonneuropathic
Hereditary Amyloidosis With Primary Renal Involement	AMYL8
Systemic Non-Neuropathic Amyloidosis	Amyloid Nephropathy

Amyloidosis, Hereditary, Transthyretin-Related

Transthyretin Amyloidosis	Familial Amyloid Polyneuropathy
Ttr Amyloid Neuropathy	Transthyretin Amyloid Neuropathy
Transthyretin Amyloid Polyneuropathy	Fap
Familial Transthyretin Amyloidosis	Amyloidosis Transthyretin Related
Type I Familial Amyloid Polyneuropathy	Familial Amyloid Polyneuropathy Type I
Attrv122i Amyloidosis	Hereditary Amyloidosis, Transthyretin-Related
Amyloid Polyneuropathy, Familial	Attr Amyloidosis
Attrm Amyloidosis	Corino De Andrade'S Disease
Paramyloidosis	Transthyretin-Related Hereditary Amyloidosis
Ttr Amyloidosis	Hereditary Attr Amyloidosis
Portuguese Polyneuritic Amyloidosis	Portuguese Type Familial Amyloid Neuropathy
Swiss Type Amyloid Polyneuropathy	Type Ii Familial Amyloid Polyneuropathy
Attrv30m Amyloidosis	Attrv30m-Related Amyloidosis
Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type	Attr Cardiomyopathy
Attrv122i-Related Amyloidosis	Ttr-Related Amyloid Cardiomyopathy
Ttr-Related Cardiac Amyloidosis	Transthyretin Amyloid Cardiopathy
Transthyretin-Related Familial Amyloid Cardiomyopathy	Amyloidosis, Transthyretin-Related
AMYL-TTR	Amyloidosis I
Amyloidosis Ohio Type	Amyloidosis Type 7
Amyloidosis Vii	Amyloid Polyneuropathy
Attr	Familial Amyloid Polyneuropathy Type Ii
Hereditary Amyloidosis Transthyretin-Related	Leptomeningeal Amyloidosis
Meningocerebrovascular Amyloidosis	Oculoleptomeningeal Amyloidosis
Familial Amyloid Polyneuropathies	Amyloidosis, Leptomeningeal
Senile Cardiac Amyloidosis	Amyloid Neuropathies, Familial
Danish Type Familial Amyloid Cardiomyopathy	Familial Amyloid Neuropathy, Portuguese Type
Amyloid Polyneuropathy, Swiss Type	Hereditary Oculoleptomeningeal Amyloid Angiopathy
Amyloid Neuropathies

Alzheimer Disease 6

Ad6	Alzheimer Disease 6, Late-Onset
Alzheimer'S Disease 6	Alzheimer Disease 6, Late Onset

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Hyperinsulinism

Hyperinsulinemia

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Hereditary Cystatin C Amyloid Angiopathy
Cerebral Amyloid Angiopathy, Familial	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease	CJD
Bovine Spongiform Encephalopathy	Vcjd
Inherited Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Familial
Creutzfeldt Jakob Disease	Creutzfeldt-Jacob Disease
Creutzfeldt Jacob Disease	Sporadic Creutzfeldt-Jakob Disease
Encephalopathy, Bovine Spongiform	Creutzfeldt-Jakob Disease, Variant, Resistance To
Creutzfeldt-Jakob Disease, Variant	Creutzfeldt Jacob Syndrome
Jakob-Creutzfeldt Disease	Subacute Spongiform Encephalopathy
Transmissible Virus Dementia	New Variant Of Cjd
Nv-Cjd	Variant Cjd
Variant Creutzfeldt-Jacob Disease	Sporadic Cjd
Inherited Cjd	Acquired Creutzfeldt-Jakob Disease
Variant Mcj	Encephalopathy Bovine Spongiform
Familial Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Syndrome
New Variant Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Sporadic
Acquired Cjd	Scjd - [Sporadic Creutzfeldt-Jakob Disease]
Idiopathic Creutzfeldt-Jakob Disease	Creutzfeld-Jakob Disease Nos
Vcjd - [Variant Creutzfeldt-Jakob Disease]

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon

Monocarboxylate Transporter 1 Deficiency

Ketoacidosis Due To Monocarboxylate Transporter-1 Deficiency	MCT1D
Ketosis

Endocrine Gland Cancer

Endocrine Neoplasm	Malignant Neoplasm Of Endocrine Gland
Endocrine Gland Neoplasms	Endocrine Tumor
Malignant Endocrine Tumor	Malignant Tumour Of Endocrine Gland
Neoplasm Of Endocrine Gland	Neoplasm Of Endocrine System
Neoplasm Of The Endocrine System	Carcinoma Of Endocrine Gland

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1871A	Amylin (IAPP), feline TFA		98.75%	Unkown
HY-P1871	Amylin (IAPP), feline		/	Unkown
HY-P3926	Amylin (8-37) (human)		/	Unkown
HY-RS06506	IAPP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IAPP	VGNC	VGNC:41848
Felis catus	IAPP	VGNC	VGNC:84035
Bos taurus	IAPP	VGNC	VGNC:30017
Mus musculus	IAPP	MGD	MGI:96382
Rattus norvegicus	IAPP	RGD	RGD:2854
Macaca mulatta	IAPP	VGNC	VGNC:82161
Others	IAPP	NCBI