2. Gene
  3. IARS1 - isoleucyl-tRNA synthetase 1 Gene

IARS1 - isoleucyl-tRNA synthetase 1 Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as IRS; IARS; ILRS; ILERS; GRIDHH; PRO0785

Gene ID: 3376 | Gene type: protein coding

About IARS1

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I Aminoacyl-tRNA Synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

IARS1 Products(1)

mRNA Protein Name
NM_001378582.1 NP_001365511.1 isoleucine--tRNA ligase, cytoplasmic isoform 8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
24337748 GOA
enables isoleucine-tRNA ligase activity IDA
IDA: Inferred from direct assay
8052601 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9556618 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within isoleucyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
8052601 GOA
involved in isoleucyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
8052601 GOA
Cellular Component GO Annotation Evidence Reference Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
19131329 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
8052601 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19289464 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

isoleucine--tRNA ligase, cytoplasmic

isoleucine tRNA ligase 1, cytoplasmic

IARS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Anti Tag CoIP
33961781
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Pull Down
9556618
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Crosslink
30021884
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
SPR
9556618
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Y2H
10913161
Intra
IARS1 P41252 EPRS1 Homo sapiens P07814
Y2H
9556618
Cross: Cross-species interaction Intra: Intraspecies interaction