PALM3 - paralemmin 3 Gene

Homo sapiens

Gene ID: 342979 | Gene type: protein coding

About PALM3

This gene has 4 transcripts (splice variants), 1 gene allele, 104 orthologues and 3 paralogues. Biased expression in kidney (RPKM 13.7), liver (RPKM 6.5) and 10 other tissues.

Summary

Predicted to enable ATP binding activity. Involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PALM3 Products(2)

mRNA	Protein	Name
NM_001145028.2	NP_001138500.2	paralemmin-3 isoform 1
NM_001367327.1	NP_001354256.1	paralemmin-3 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21187075	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Toll signaling pathway	IMP IMP: Inferred from mutant phenotype	21187075	GOA
involved in negative regulation of cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	21187075	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	21187075	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paralemmin-3

Related Diseases

Diseases

Alias

Median Neuropathy

Leopard Syndrome 1

LPRD1	Noonan Syndrome With Multiple Lentigines 1
Lentiginosis, Cardiomyopathic	Multiple Lentigines Syndrome
Leopard Syndrome, Type 1	Leopard Syndrome
Multiple Lentigines

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10031A	SAR441255 TFA	Agonist	99.65%	Phase 1
HY-P10031	SAR441255	Agonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10379	palm-PrRP31	Agonist	/	Unkown
HY-P10380	palm11-PrRP31	Agonist	/	Unkown
HY-RS10007	PALM3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PALM3	VGNC	VGNC:44248
Rattus norvegicus	PALM3	RGD	RGD:2323602
Bos taurus	PALM3	VGNC	VGNC:32559
Mus musculus	PALM3	MGD	MGI:1921587

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