MSGN1 - mesogenin 1 Gene

Homo sapiens

Also known as MSOG; pMsgn1

Gene ID: 343930 | Gene type: protein coding

About MSGN1

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,816,460-17,817,798 (from NCBI)

This gene has 1 transcript (splice variant), 176 orthologues and 2 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in mesoderm formation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within segment specification and somitogenesis. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MSGN1 Products(1)

mRNA	Protein	Name
NM_001105569.3	NP_001099039.1	mesogenin-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSGN1 Protein Structure

HLH

0
100
193 a.a.

Protein Preferred Names

Protein Names

mesogenin-1

pMesogenin1

MSGN1 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSGN1	A6NI15	ZWINT	Homo sapiens	O95229	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	ZWINT	Homo sapiens	O95229	Validated Y2H	32296183
Intra	MSGN1	A6NI15	ZWINT	Homo sapiens	O95229	Y2H Array	32296183
Intra	MSGN1	A6NI15	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	MSGN1	A6NI15	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	32296183
Intra	MSGN1	A6NI15	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
Intra	MSGN1	A6NI15	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	MSGN1	A6NI15	BRAT1	Homo sapiens	Q6PJG6	Validated Y2H	32296183
Intra	MSGN1	A6NI15	BRAT1	Homo sapiens	Q6PJG6	Y2H Array	32296183
Intra	MSGN1	A6NI15	BRAT1	Homo sapiens	Q6PJG6	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	MSGN1	A6NI15	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	CTAG1A	Homo sapiens	P78358	Validated Y2H	32296183
Intra	MSGN1	A6NI15	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	MSGN1	A6NI15	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	MSGN1	A6NI15	AP1B1	Homo sapiens	Q10567-3	Y2H Array	32296183
Intra	MSGN1	A6NI15	AP1B1	Homo sapiens	Q10567-3	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	AP1B1	Homo sapiens	Q10567-3	Validated Y2H	32296183
Intra	MSGN1	A6NI15	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	MSGN1	A6NI15	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TEX12	Homo sapiens	Q9BXU0	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TEX12	Homo sapiens	Q9BXU0	Y2H Array	32296183
Intra	MSGN1	A6NI15	TEX12	Homo sapiens	Q9BXU0	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	ID1	Homo sapiens	P41134	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	ID1	Homo sapiens	P41134	Validated Y2H	32296183
Intra	MSGN1	A6NI15	ID1	Homo sapiens	P41134	Y2H Array	32296183
Intra	MSGN1	A6NI15	MYL9	Homo sapiens	P24844-2	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	MYL9	Homo sapiens	P24844-2	Y2H Array	32296183
Intra	MSGN1	A6NI15	MYL9	Homo sapiens	P24844-2	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TCF4	Homo sapiens	P15884-3	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	MSGN1	A6NI15	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	ID3	Homo sapiens	Q02535	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	ID3	Homo sapiens	Q02535	Y2H Array	32296183
Intra	MSGN1	A6NI15	ID3	Homo sapiens	Q02535	Validated Y2H	32296183
Intra	MSGN1	A6NI15	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	MSGN1	A6NI15	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	MYF5	Homo sapiens	P13349	Validated Y2H	32296183
Intra	MSGN1	A6NI15	OST4	Homo sapiens	P0C6T2	Validated Y2H	32296183
Intra	MSGN1	A6NI15	OST4	Homo sapiens	P0C6T2	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	OST4	Homo sapiens	P0C6T2	Y2H Array	32296183
Intra	MSGN1	A6NI15	CCDC172	Homo sapiens	P0C7W6	Validated Y2H	32296183
Intra	MSGN1	A6NI15	CCDC172	Homo sapiens	P0C7W6	Y2H Array	32296183
Intra	MSGN1	A6NI15	CCDC172	Homo sapiens	P0C7W6	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	TRAF1	Homo sapiens	Q13077	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	MSGN1	A6NI15	DNALI1	Homo sapiens	O14645	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	DNALI1	Homo sapiens	O14645	Y2H Array	32296183
Intra	MSGN1	A6NI15	DNALI1	Homo sapiens	O14645	Validated Y2H	32296183
Intra	MSGN1	A6NI15	EXOC7	Homo sapiens	Q9UPT5-1	Validated Y2H	32296183
Intra	MSGN1	A6NI15	ITGB3BP	Homo sapiens	Q13352	Validated Y2H	32296183
Intra	MSGN1	A6NI15	ITGB3BP	Homo sapiens	Q13352	Y2H Array	32296183
Intra	MSGN1	A6NI15	ITGB3BP	Homo sapiens	Q13352	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	HAP1	Homo sapiens	P54257	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	HAP1	Homo sapiens	P54257	Y2H Array	32296183
Intra	MSGN1	A6NI15	HAP1	Homo sapiens	P54257	Validated Y2H	32296183
Intra	MSGN1	A6NI15	ID2	Homo sapiens	Q02363	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	ID2	Homo sapiens	Q02363	Validated Y2H	32296183
Intra	MSGN1	A6NI15	ID2	Homo sapiens	Q02363	Y2H Array	32296183
Intra	MSGN1	A6NI15	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	LDOC1	Homo sapiens	O95751	Validated Y2H	32296183
Intra	MSGN1	A6NI15	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	MSGN1	A6NI15	SERTAD3	Homo sapiens	Q9UJW9	Y2H Array	32296183
Intra	MSGN1	A6NI15	SERTAD3	Homo sapiens	Q9UJW9	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	SERTAD3	Homo sapiens	Q9UJW9	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TTC23L	Homo sapiens	Q6PF05	Y2H Prey Pooling	32296183
Intra	MSGN1	A6NI15	TTC23L	Homo sapiens	Q6PF05	Validated Y2H	32296183
Intra	MSGN1	A6NI15	TTC23L	Homo sapiens	Q6PF05	Y2H Array	32296183
Intra	MSGN1	A6NI15	IGFBP6	Homo sapiens	P24592	Validated Y2H	32296183
Intra	MSGN1	A6NI15	IGFBP6	Homo sapiens	P24592	Y2H Array	32296183
Intra	MSGN1	A6NI15	IGFBP6	Homo sapiens	P24592	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spondylocostal Dysostosis 4, Autosomal Recessive

SCDO4	Spondylocostal Dysostosis 4
Autosomal Recessive Spondylocostal Dysostosis 4	Doid:0112364
Dysostosis, Spondylocostal, Autosomal Recessive, Type 4

Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome	SCDO1
Vertebral Anomalies	Spondylothoracic Dysplasia
Costovertebral Dysplasia	Spondylothoracic Dysostosis
Spondylocostal Dysostosis 1	Autosomal Recessive Spondylocostal Dysostosis 1
Spondylocostal Dysostosis, Autosomal Recessive, 1	Doid:0112365
Dysostosis, Spondylocostal, Autosomal Recessive, Type 1

Spondylocostal Dysostosis

Jarcho-Levin Syndrome	Costovertebral Dysplasia
Spondylothoracic Dysostosis	Spondylothoracic Dysplasia
Scdo	Dysostosis, Spondylocostal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS08708	MSGN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MSGN1	VGNC	VGNC:74771
Bos taurus	MSGN1	VGNC	VGNC:31692
Mus musculus	MSGN1	MGD	MGI:1860483
Rattus norvegicus	MSGN1	RGD	RGD:1587516
Canis familiaris	MSGN1	VGNC	VGNC:43437

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