MSGN1 - mesogenin 1 Gene

Homo sapiens

Also known as MSOG; pMsgn1

Gene ID: 343930 | Gene type: protein coding

About MSGN1

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,816,460-17,817,798 (from NCBI)

This gene has 1 transcript (splice variant), 176 orthologues and 2 paralogues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in mesoderm formation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within segment specification and somitogenesis. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MSGN1 Products(1)

mRNA	Protein	Name
NM_001105569.3	NP_001099039.1	mesogenin-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSGN1 Protein Structure

HLH

0
100
193 a.a.

Protein Preferred Names

Protein Names

mesogenin-1

pMesogenin1

Related Diseases

Diseases

Alias

Spondylocostal Dysostosis 4, Autosomal Recessive

SCDO4	Spondylocostal Dysostosis 4
Autosomal Recessive Spondylocostal Dysostosis 4	Doid:0112364
Dysostosis, Spondylocostal, Autosomal Recessive, Type 4

Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome	SCDO1
Vertebral Anomalies	Spondylothoracic Dysplasia
Costovertebral Dysplasia	Spondylothoracic Dysostosis
Spondylocostal Dysostosis 1	Autosomal Recessive Spondylocostal Dysostosis 1
Spondylocostal Dysostosis, Autosomal Recessive, 1	Doid:0112365
Dysostosis, Spondylocostal, Autosomal Recessive, Type 1

Spondylocostal Dysostosis

Jarcho-Levin Syndrome	Costovertebral Dysplasia
Spondylothoracic Dysostosis	Spondylothoracic Dysplasia
Scdo	Dysostosis, Spondylocostal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08708	MSGN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MSGN1	VGNC	VGNC:74771
Bos taurus	MSGN1	VGNC	VGNC:31692
Mus musculus	MSGN1	MGD	MGI:1860483
Rattus norvegicus	MSGN1	RGD	RGD:1587516
Canis familiaris	MSGN1	VGNC	VGNC:43437

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