2. Gene
  3. STRA8 - stimulated by retinoic acid 8 Gene

STRA8 - stimulated by retinoic acid 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 346673 | Gene type: protein coding

About STRA8

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,231,915-135,258,663 (from NCBI)

This gene has 3 transcripts (splice variants) and 133 orthologues. Low expression observed in reference dataset.

Summary

This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

STRA8 Products(2)

mRNA Protein Name
NM_001394401.1 NP_001381330.1 stimulated by retinoic acid gene 8 protein homolog isoform 1
NM_182489.3 NP_872295.2 stimulated by retinoic acid gene 8 protein homolog isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
22899867 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

stimulated by retinoic acid gene 8 protein homolog

STRA8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 SERTAD2 Homo sapiens Q14140
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 SERTAD2 Homo sapiens Q14140
Y2H Prey Pooling
32296183
Intra
STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Validated Y2H
32296183
Intra
STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Y2H Array
32296183
Intra
STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spastic Paraplegia 24, Autosomal Recessive

SPG24

Spastic Paraplegia 24

Hereditary Spastic Paraplegia 24

Autosomal Recessive Spastic Paraplegia Type 24

Autosomal Recessive Spastic Paraplegia 24
Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome

Germinal Cell Aplasia

Del Castillo Syndrome

SPGFX1

X-Linked Spermatogenic Failure 1

Congenital Absence Of Germinal Epithelium Of Testes
Hereditary Spastic Paraplegia 56

Autosomal Recessive Spastic Paraplegia Type 56

Spg56

Autosomal Recessive Spastic Paraplegia 56
Spermatocytoma

Spermatocytic Seminoma
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders
Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Disorder Of Sexual Development

Disorder Of Sex Development

Disorders Of Sex Development

Sex Development Disorder

Sex Differentiation Disease

Dsd

Sex Differentiation Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W011094 Win 18446 Inhibitor 98.57% Unkown
HY-RS13958 STRA8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STRA8 VGNC VGNC:65800
Rattus norvegicus STRA8 RGD RGD:1562852
Bos taurus STRA8 VGNC VGNC:53678
Canis familiaris STRA8 VGNC VGNC:46938
Mus musculus STRA8 MGD MGI:107917
Macaca mulatta STRA8 VGNC VGNC:78250