2. Gene
  3. ILF3 - interleukin enhancer binding factor 3 Gene

ILF3 - interleukin enhancer binding factor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NF90c; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; NFAR-2; NFAR90; TCP110; MPP4110; NF90ctv; NFAR110; MPHOSPH4; NF-AT-90

Gene ID: 3609 | Gene type: protein coding

About ILF3

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,654,346-10,692,400 (from NCBI)

This gene has 23 transcripts (splice variants), 220 orthologues and 14 paralogues. Ubiquitous expression in bone marrow (RPKM 45.0), testis (RPKM 34.6) and 25 other tissues.

Summary

This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with Other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]

ILF3 Products(24)

mRNA Protein Name
NM_001137673.2 NP_001131145.1 interleukin enhancer-binding factor 3 isoform e
NM_001394808.1 NP_001381737.1 interleukin enhancer-binding factor 3 isoform d
NM_001394809.1 NP_001381738.1 interleukin enhancer-binding factor 3 isoform d
NM_001394810.1 NP_001381739.1 interleukin enhancer-binding factor 3 isoform d
NM_001394811.1 NP_001381740.1 interleukin enhancer-binding factor 3 isoform a
NM_001394812.1 NP_001381741.1 interleukin enhancer-binding factor 3 isoform a
NM_001394813.1 NP_001381742.1 interleukin enhancer-binding factor 3 isoform f
NM_001394814.1 NP_001381743.1 interleukin enhancer-binding factor 3 isoform g
NM_001394815.1 NP_001381744.1 interleukin enhancer-binding factor 3 isoform h
NM_001394816.1 NP_001381745.1 interleukin enhancer-binding factor 3 isoform h
NM_001394817.1 NP_001381746.1 interleukin enhancer-binding factor 3 isoform i
NM_001394818.1 NP_001381747.1 interleukin enhancer-binding factor 3 isoform j
NM_001394819.1 NP_001381748.1 interleukin enhancer-binding factor 3 isoform k
NM_001394820.1 NP_001381749.1 interleukin enhancer-binding factor 3 isoform k
NM_001394821.1 NP_001381750.1 interleukin enhancer-binding factor 3 isoform e
NM_001394822.1 NP_001381751.1 interleukin enhancer-binding factor 3 isoform e
NM_001394823.1 NP_001381752.1 interleukin enhancer-binding factor 3 isoform e
NM_001394824.1 NP_001381753.1 interleukin enhancer-binding factor 3 isoform b
NM_001394826.1 NP_001381755.1 interleukin enhancer-binding factor 3 isoform b
NM_001394827.1 NP_001381756.1 interleukin enhancer-binding factor 3 isoform l
NM_004516.4 NP_004507.2 interleukin enhancer-binding factor 3 isoform b
NM_012218.4 NP_036350.2 interleukin enhancer-binding factor 3 isoform a
NM_017620.3 NP_060090.2 interleukin enhancer-binding factor 3 isoform d
NM_153464.3 NP_703194.1 interleukin enhancer-binding factor 3 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
7519613 GOA
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
10574923 GOA
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: Inferred from direct assay
14731398 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9442054 GOA
enables virus receptor activity IDA
IDA: Inferred from direct assay
21123651 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11739746 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11739746 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
21123651 GOA
involved in spliceosome-depend formation of circular RNA IDA
IDA: Inferred from direct assay
28625552 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21123651 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8885239 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILF3 Protein Structure

DZF

DZF: DZF domain (94 - 342)

dsrm

dsrm: Double-stranded RNA binding motif (403 - 464)

dsrm

dsrm: Double-stranded RNA binding motif (529 - 588)

  • 0
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  • 400
  • 600
  • 800
  • 894 a.a.
Protein Preferred Names Protein Names

interleukin enhancer-binding factor 3

M phase phosphoprotein 4, nuclear factor associated with DS RNA

ILF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
ILF3 Q12906 M Vesicular stomatitis New Jersey virus P08325
Anti Bait CoIP
18337511
Intra
ILF3 Q12906 HNRNPA2B1 Homo sapiens P22626
Anti Tag CoIP
35271311
Intra
ILF3 Q12906 HNRNPA2B1 Homo sapiens P22626
Anti Bait CoIP
23976881
Intra
ILF3 Q12906 PRMT1 Homo sapiens Q99873
Anti Bait CoIP
10749851
Intra
ILF3 Q12906 PRMT1 Homo sapiens Q99873
Anti Tag CoIP
35271311
Cross
ILF3 Q12906 NS Influenza A virus P03496
Y2H Array
23853584
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Childhood Endodermal Sinus Tumor

Childhood Endodermal Sinus Neoplasm

Childhood Endodermal Sinus Tumour

Paediatric Yolk Sac Tumour

Pediatric Yolk Sac Tumor

Childhood Yolk Sac Tumor
Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06786 ILF3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ILF3 VGNC VGNC:67791
Macaca mulatta ILF3 VGNC VGNC:73737
Rattus norvegicus ILF3 RGD RGD:619734
Canis familiaris ILF3 VGNC VGNC:42000
Bos taurus ILF3 VGNC VGNC:30176
Mus musculus ILF3 MGD MGI:1339973