ING2 - inhibitor of growth family member 2 Gene

Homo sapiens

Also known as ING1L; p33ING2

Gene ID: 3622 | Gene type: protein coding

About ING2

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:183,505,058-183,512,429 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 10.5), adrenal (RPKM 8.4) and 25 other tissues.

Summary

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of Histone Acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

ING2 Products(2)

mRNA	Protein	Name
NM_001291959.2	NP_001278888.1	inhibitor of growth protein 2 isoform 2
NM_001564.4	NP_001555.1	inhibitor of growth protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15243141	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	16728974	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	16893883	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18334480	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18334480	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18334480	GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	18334480	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15243141	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCAAT-binding factor complex	IDA IDA: Inferred from direct assay	15243141	GOA
part of Sin3-type complex	IDA IDA: Inferred from direct assay	16387653	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15243141	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	25578879	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	25578879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ING2 Protein Structure

ING

PHD

0
100
200
280 a.a.

Protein Preferred Names

Protein Names

inhibitor of growth protein 2

ING1Lp

ING2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ING2	Q9H160	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	33961781
Intra	ING2	Q9H160	SIN3A	Homo sapiens	Q96ST3	Anti Bait CoIP	20676127
Intra	ING2	Q9H160	SIN3A	Homo sapiens	Q96ST3	Anti Tag CoIP	28514442
Intra	ING2	Q9H160	PCNA	Homo sapiens	P12004	Anti Bait CoIP	19730436
Intra	ING2	Q9H160	PCNA	Homo sapiens	P12004	Pull Down	19730436
Intra	ING2	Q9H160	SMURF1	Homo sapiens	Q9HCE7-2	Pull Down	20621832
Intra	ING2	Q9H160	SMURF1	Homo sapiens	Q9HCE7-2	Anti Tag CoIP	20621832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06808	ING2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ING2	VGNC	VGNC:30195
Canis familiaris	ING2	VGNC	VGNC:42017
Mus musculus	ING2	MGD	MGI:1916510
Felis catus	ING2	VGNC	VGNC:67803
Macaca mulatta	ING2	VGNC	VGNC:73743
Rattus norvegicus	ING2	RGD	RGD:1307347

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