IRF7 - interferon regulatory factor 7 Gene

Homo sapiens

Also known as IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H

Gene ID: 3665 | Gene type: protein coding

About IRF7

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:612,555-615,950 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 203 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in spleen (RPKM 16.7), lymph node (RPKM 8.9) and 24 other tissues.

Summary

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]

IRF7 Products(3)

mRNA	Protein	Name
NM_001572.5	NP_001563.2	interferon regulatory factor 7 isoform a
NM_004029.4	NP_004020.1	interferon regulatory factor 7 isoform b
NM_004031.4	NP_004022.2	interferon regulatory factor 7 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IMP IMP: Inferred from mutant phenotype	12374802	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17404045	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17404045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11943871	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	21931555	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12374802	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	22065573	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16127453	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	17404045	GOA
involved in regulation of adaptive immune response	IDA IDA: Inferred from direct assay	17404045	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	11473119	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19176627	GOA
located in cytoplasm	IGI IGI: Inferred from genetic interaction	23729669	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22065573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRF7 Protein Structure

IRF

IRF-3

0
100
200
300
400
503 a.a.

Protein Preferred Names

Protein Names

interferon regulatory factor 7

interferon regulatory factor-7H

IRF7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IRF7	Q92985	LTN1	Homo sapiens	O94822	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	TLK2	Homo sapiens	Q86UE8	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	TRMT61B	Homo sapiens	Q9BVS5	Pull Down	30833792
Intra	IRF7	Q92985	TRMT61B	Homo sapiens	Q9BVS5	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	TBK1	Homo sapiens	Q9UHD2	Y2H	17599067
Intra	IRF7	Q92985	IRAK1	Homo sapiens	P51617	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	ARAF	Homo sapiens	P10398	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	PALD1	Homo sapiens	Q9ULE6	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	AIP	Homo sapiens	O00170	Anti Tag CoIP	21903422
Intra	IRF7	Q92985	CCDC47	Homo sapiens	Q96A33	Anti Tag CoIP	21903422
Cross	IRF7	Q92985	ORF45	Human herpesvirus 8	F5HDE4	Y2H	11943871
Cross	IRF7	Q92985	ORF45	Human herpesvirus 8	F5HDE4	Pull Down	11943871
Cross	IRF7	Q92985	P	Measles virus	Q77M19	Pull Down	18922877

Cross: Cross-species interaction Intra: Intraspecies interaction

IRF7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82718	IRF7 Antibody (YA2463)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat

Related Diseases

Diseases

Alias

Immunodeficiency 39

IMD39

Immunodeficiency, Type 39

Predisposition To Severe Viral Infection Due To Irf7 Deficiency

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Newcastle Disease

Newcastle'S Disease

Pseudo-Fowlpest

Yellow Fever

Urban Yellow Fever	Jungle Yellow Fever
Sylvatic Yellow Fever	Yf
Yellow Fever, Sylvan	Bronze John
Yellow Jack	Yf- [Yellow Fever]
Febris Flava

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Vaccinia

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Lyme Disease

Lyme Borreliosis	Lyme Neuroborreliosis
Borreliosis	Borrelia Burgdorferi Infection
Neuroborreliosis	Bannwarth Syndrome
Bannworth'S Syndrome	Neurological Lyme Disease
B. Burgdorferi Infection	Borreliosis, Lyme
Infection By Borrelia Burgdorferi	Infection Due To Borrelia Burgdorferi Sensu Lato
Lym	Borrelia Infections

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma	Multicentric Basal Cell Carcinoma
Superficial Multicentric Basal-Cell Carcinoma

Oral Hairy Leukoplakia

Hairy Leukoplakia	Leukoplakia, Hairy
Hairy Leucoplakia

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117066	CL075	Agonist	99.25%	Unkown
HY-122891	SB02024		99.7%	Unkown
HY-RS06911	IRF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IRF7	MGD	MGI:1859212
Macaca mulatta	IRF7	VGNC	VGNC:73765
Felis catus	IRF7	VGNC	VGNC:67829
Rattus norvegicus	IRF7	RGD	RGD:1307828
Bos taurus	IRF7	VGNC	VGNC:30278

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