HDDC3 - HD domain containing 3 Gene

Homo sapiens

Also known as MESH1; (ppGpp)ase

Gene ID: 374659 | Gene type: protein coding

About HDDC3

This gene has 10 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in fat (RPKM 9.9), kidney (RPKM 7.9) and 25 other tissues.

Summary

Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]

HDDC3 Products(2)

mRNA	Protein	Name
NM_001286451.2	NP_001273380.1	guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 1
NM_198527.4	NP_940929.1	guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDDC3 Protein Structure

HD_4

0
100
179 a.a.

Protein Preferred Names

Protein Names

guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

HD domain-containing protein 3

HDDC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HDDC3	Q8N4P3	GOLGA8F	Homo sapiens	Q08AF8	Validated Y2H	25416956
Intra	HDDC3	Q8N4P3	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	25416956
Intra	HDDC3	Q8N4P3	GOLGA8DP	Homo sapiens	Q0D2H9	Validated Y2H	25416956
Intra	HDDC3	Q8N4P3	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Array	25416956
Intra	HDDC3	Q8N4P3	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Prey Pooling	25416956
Intra	HDDC3	Q8N4P3	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	HDDC3	Q8N4P3	TPM3	Homo sapiens	Q5VU62	Validated Y2H	25416956
Intra	HDDC3	Q8N4P3	TPM3	Homo sapiens	Q5VU62	Y2H Array	25416956
Intra	HDDC3	Q8N4P3	TPM3	Homo sapiens	Q5VU62	Y2H Prey Pooling	25416956
Intra	HDDC3	Q8N4P3	CCDC172	Homo sapiens	P0C7W6	Y2H Array	31515488
Intra	HDDC3	Q8N4P3	CCDC172	Homo sapiens	P0C7W6	Validated Y2H	25416956
Intra	HDDC3	Q8N4P3	TNIP1	Homo sapiens	Q15025	Anti Tag CoIP	33961781
Intra	HDDC3	Q8N4P3	NMI	Homo sapiens	Q13287	Y2H Prey Pooling	25416956
Intra	HDDC3	Q8N4P3	NMI	Homo sapiens	Q13287	Y2H Array	25416956
Intra	HDDC3	Q8N4P3	GKAP1	Homo sapiens	Q5VSY0	Y2H Array	25416956
Intra	HDDC3	Q8N4P3	GKAP1	Homo sapiens	Q5VSY0	Validated Y2H	25416956
Intra	HDDC3	Q8N4P3	EXOC5	Homo sapiens	O00471	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06093	HDDC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HDDC3	VGNC	VGNC:108304
Canis familiaris	HDDC3	VGNC	VGNC:41626
Felis catus	HDDC3	VGNC	VGNC:62772
Rattus norvegicus	HDDC3	RGD	RGD:1311839
Mus musculus	HDDC3	MGD	MGI:1915945
Bos taurus	HDDC3	VGNC	VGNC:29786

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