GKAP1 - G kinase anchoring protein 1 Gene

Homo sapiens

Also known as FKSG21; GKAP42

Gene ID: 80318 | Gene type: protein coding

About GKAP1

Cytogenetic location: 9q21.32 Genomic coordinates (GRCh38): 9:83,739,425-83,817,769 (from NCBI)

This gene has 7 transcripts (splice variants) and 205 orthologues. Biased expression in testis (RPKM 88.6) and ovary (RPKM 4.2).

Summary

This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GKAP1 Products(2)

mRNA	Protein	Name
NM_001135953.2	NP_001129425.1	G kinase-anchoring protein 1 isoform b
NM_025211.4	NP_079487.2	G kinase-anchoring protein 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

G kinase-anchoring protein 1

cGMP-dependent protein kinase anchoring protein 42kDa

GKAP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GKAP1	Q5VSY0	DYR	Homo sapiens	B0YJ76	Y2H Array	25416956
Intra	GKAP1	Q5VSY0	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	GKAP1	Q5VSY0	FAM124B	Homo sapiens	Q9H5Z6-2	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	PHOSPHO2	Homo sapiens	Q8TCD6	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	L3MBTL2	Homo sapiens	Q969R5	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	MMTAG2	Homo sapiens	Q9BU76	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	HDDC3	Homo sapiens	Q8N4P3	Y2H Prey Pooling	25416956
Intra	GKAP1	Q5VSY0	GKAP1	Homo sapiens	Q5VSY0	Y2H Array	32296183
Intra	GKAP1	Q5VSY0	GCD7	Saccharomyces cerevisiae	P32502	Y2H Array	27107014
Intra	GKAP1	Q5VSY0	GCD7	Saccharomyces cerevisiae	P32502	Y2H Pooling	27107014
Intra	GKAP1	Q5VSY0	GKAP1	Homo sapiens	Q5VSY0	Validated Y2H	32296183
Intra	GKAP1	Q5VSY0	GKAP1	Homo sapiens	Q5VSY0	Y2H Prey Pooling	32296183
Intra	GKAP1	Q5VSY0	GKAP1	Homo sapiens	Q5VSY0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05460	GKAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GKAP1	VGNC	VGNC:29387
Felis catus	GKAP1	VGNC	VGNC:62569
Mus musculus	GKAP1	MGD	MGI:1891694
Canis familiaris	GKAP1	VGNC	VGNC:41245
Rattus norvegicus	GKAP1	RGD	RGD:1306955

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