SWI5 - SWI5 homologous recombination repair protein Gene

Homo sapiens

Also known as SAE3; C9orf119

Gene ID: 375757 | Gene type: protein coding

About SWI5

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,275,356-128,288,989 (from NCBI)

This gene has 7 transcripts (splice variants) and 178 orthologues. Broad expression in testis (RPKM 16.4), thyroid (RPKM 8.7) and 25 other tissues.

Summary

Involved in cellular response to ionizing radiation and double-strand break repair via homologous recombination. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Apr 2022]

SWI5 Products(4)

mRNA	Protein	Name
NM_001040011.2	NP_001035100.2	DNA repair protein SWI5 homolog isoform 1
NM_001318089.2	NP_001305018.2	DNA repair protein SWI5 homolog isoform 2
NM_001318092.2	NP_001305021.1	DNA repair protein SWI5 homolog isoform 3
NM_001379267.1	NP_001366196.1	DNA repair protein SWI5 homolog isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21252223	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	23754376	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	21252223	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Swi5-Sfr1 complex	IDA IDA: Inferred from direct assay	21252223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SWI5 Protein Structure

Swi5

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

DNA repair protein SWI5 homolog

HBV DNAPTP1-transactivated protein A

Related Diseases

Diseases

Alias

Hordeolum

Stye	Boil Of Eyelid
Furuncle Of Eyelid	Hordeolum Externum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14064	SWI5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SWI5	RGD	RGD:1559966
Mus musculus	SWI5	MGD	MGI:1920181
Felis catus	SWI5	VGNC	VGNC:102993
Canis familiaris	SWI5	VGNC	VGNC:106612

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