SFR1 - SWI5 dependent homologous recombination repair protein 1 Gene

Homo sapiens

Also known as MEI5; MEIR5; C10orf78; bA373N18.1

Gene ID: 119392 | Gene type: protein coding

About SFR1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,120,166-104,126,383 (from NCBI)

This gene has 3 transcripts (splice variants) and 190 orthologues. Broad expression in testis (RPKM 6.8), appendix (RPKM 2.8) and 25 other tissues.

Summary

Enables nuclear receptor coactivator activity. Involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Apr 2022]

SFR1 Products(4)

mRNA	Protein	Name
NM_001002759.2	NP_001002759.1	swi5-dependent recombination DNA repair protein 1 homolog isoform a
NM_001384829.1	NP_001371758.1	swi5-dependent recombination DNA repair protein 1 homolog isoform b
NM_001384830.1	NP_001371759.1	swi5-dependent recombination DNA repair protein 1 homolog isoform b
NM_145247.5	NP_660290.3	swi5-dependent recombination DNA repair protein 1 homolog isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	23874500	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21252223	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	23874500	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	21252223	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23874500	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Swi5-Sfr1 complex	IDA IDA: Inferred from direct assay	21252223	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23874500	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFR1 Protein Structure

Mei5

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

swi5-dependent recombination DNA repair protein 1 homolog

MEI5 recombination repair protein homolog

Related Diseases

Diseases

Alias

Atrial Septal Defect 4

ASD4	Atrial Heart Septal Defect 4
Septal Defect, Atrial, Type 4

Atrial Septal Defect 3

ASD3	Atrial Heart Septal Defect 3
Septal Defect, Atrial, Type 3

Branchiootorenal Syndrome 2

BOR2	Bor Syndrome 2
Branchiootorenal Dysplasia 2	Branchio-Oto-Renal Dysplasia 2
Branchio-Oto-Renal Syndrome Type 2	Branchiootorenal Syndrome, Type 2

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12771	SFR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SFR1	VGNC	VGNC:34519
Macaca mulatta	SFR1	VGNC	VGNC:106099
Mus musculus	SFR1	MGD	MGI:1915038
Rattus norvegicus	SFR1	RGD	RGD:1305481
Canis familiaris	SFR1	VGNC	VGNC:46079
Felis catus	SFR1	VGNC	VGNC:65063

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