SFR1 - SWI5 dependent homologous recombination repair protein 1 Gene

Homo sapiens

Also known as MEI5; MEIR5; C10orf78; bA373N18.1

Gene ID: 119392 | Gene type: protein coding

About SFR1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,120,166-104,126,383 (from NCBI)

This gene has 3 transcripts (splice variants) and 190 orthologues. Broad expression in testis (RPKM 6.8), appendix (RPKM 2.8) and 25 other tissues.

Summary

Enables nuclear receptor coactivator activity. Involved in cellular response to estrogen stimulus; double-strand break repair via homologous recombination; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of Swi5-Sfr1 complex. [provided by Alliance of Genome Resources, Apr 2022]

SFR1 Products(4)

mRNA	Protein	Name
NM_001002759.2	NP_001002759.1	swi5-dependent recombination DNA repair protein 1 homolog isoform a
NM_001384829.1	NP_001371758.1	swi5-dependent recombination DNA repair protein 1 homolog isoform b
NM_001384830.1	NP_001371759.1	swi5-dependent recombination DNA repair protein 1 homolog isoform b
NM_145247.5	NP_660290.3	swi5-dependent recombination DNA repair protein 1 homolog isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	23874500	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21252223	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	23874500	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	21252223	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23874500	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Swi5-Sfr1 complex	IDA IDA: Inferred from direct assay	21252223	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23874500	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFR1 Protein Structure

Mei5

0
100
200
245 a.a.

Protein Preferred Names

Protein Names

swi5-dependent recombination DNA repair protein 1 homolog

MEI5 recombination repair protein homolog

SFR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SFR1	Q86XK3	HMBOX1	Homo sapiens	Q6NT76-2	Validated Y2H	25416956
Intra	SFR1	Q86XK3	HMBOX1	Homo sapiens	Q6NT76-2	Y2H Array	25416956
Intra	SFR1	Q86XK3	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	SFR1	Q86XK3	SWI5	Homo sapiens	Q1ZZU3	Anti Tag CoIP	33961781
Intra	SFR1	Q86XK3	SWI5	Homo sapiens	Q1ZZU3	Anti Tag CoIP	21252223
Intra	SFR1	Q86XK3	SWI5	Homo sapiens	Q1ZZU3	Pull Down	21252223
Intra	SFR1	Q86XK3	NMI	Homo sapiens	Q13287	Validated Y2H	25416956
Intra	SFR1	Q86XK3	NDC80	Homo sapiens	O14777	Validated Y2H	25416956
Intra	SFR1	Q86XK3	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	31515488
Intra	SFR1	Q86XK3	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	25416956
Intra	SFR1	Q86XK3	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	25416956
Intra	SFR1	Q86XK3	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	SFR1	Q86XK3	RNF40	Homo sapiens	O75150	Validated Y2H	25416956
Intra	SFR1	Q86XK3	RNF40	Homo sapiens	O75150	Y2H Array	25416956
Intra	SFR1	Q86XK3	RNF40	Homo sapiens	O75150	Anti Tag CoIP	33961781
Intra	SFR1	Q86XK3	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	SFR1	Q86XK3	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Atrial Septal Defect 4

ASD4	Atrial Heart Septal Defect 4
Septal Defect, Atrial, Type 4

Atrial Septal Defect 3

ASD3	Atrial Heart Septal Defect 3
Septal Defect, Atrial, Type 3

Branchiootorenal Syndrome 2

BOR2	Bor Syndrome 2
Branchiootorenal Dysplasia 2	Branchio-Oto-Renal Dysplasia 2
Branchio-Oto-Renal Syndrome Type 2	Branchiootorenal Syndrome, Type 2

Atrial Septal Defect 2

ASD2	Atrial Heart Septal Defect 2
Atrial Septal Defect-2	Asd Ii
Septal Defect, Atrial, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12771	SFR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SFR1	VGNC	VGNC:34519
Macaca mulatta	SFR1	VGNC	VGNC:106099
Mus musculus	SFR1	MGD	MGI:1915038
Rattus norvegicus	SFR1	RGD	RGD:1305481
Canis familiaris	SFR1	VGNC	VGNC:46079
Felis catus	SFR1	VGNC	VGNC:65063

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