KCNK1 - potassium two pore domain channel subfamily K member 1 Gene

Homo sapiens

Also known as DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1

Gene ID: 3775 | Gene type: protein coding

About KCNK1

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:233,614,106-233,672,514 (from NCBI)

This gene has 6 transcripts (splice variants), 234 orthologues and 14 paralogues. Broad expression in brain (RPKM 19.7), stomach (RPKM 14.9) and 18 other tissues.

Summary

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require Other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

KCNK1 Products(1)

mRNA	Protein	Name
NM_002245.4	NP_002236.1	potassium channel subfamily K member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20498050	GOA
enables potassium channel activity	IDA IDA: Inferred from direct assay	22282804	GOA
enables potassium ion leak channel activity	IDA IDA: Inferred from direct assay	21653227	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20498050	GOA
enables sodium channel activity	IDA IDA: Inferred from direct assay	21653227	GOA
NOT enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	21653227	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	21653227	GOA
involved in regulation of resting membrane potential	IMP IMP: Inferred from mutant phenotype	21653227	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	21653227	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	22282804	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21653227	GOA
part of potassium channel complex	IDA IDA: Inferred from direct assay	22282804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNK1 Protein Structure

Ion_trans_2

0
100
200
300
336 a.a.

Protein Preferred Names

Protein Names

potassium channel subfamily K member 1

inward rectifying potassium channel protein TWIK-1

KCNK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCNK1	O00180	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	KCNK1	O00180	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	CDIPT	Homo sapiens	O14735	Y2H Array	32296183
Intra	KCNK1	O00180	CDIPT	Homo sapiens	O14735	Validated Y2H	32296183
Intra	KCNK1	O00180	KCNK1	Homo sapiens	O00180	FRET	20498050
Intra	KCNK1	O00180	386682	Homo sapiens	EBI-10171679	Validated Y2H	25416956
Intra	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	386682	Homo sapiens	EBI-10171679	Y2H Array	25416956
Intra	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	KCNK1	O00180	KCNK1	Homo sapiens	O00180	X-Ray Diffraction	22282804
Intra	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	KCNK1	O00180	SUMO1	Homo sapiens	P63165	Pull Down	20498050
Intra	KCNK1	O00180	SUMO1	Homo sapiens	P63165	FRET	20498050
Intra	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myasthenic Syndrome, Congenital, 8

Congenital Myasthenic Syndrome 8	CMS8
Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects	Cmsppd
Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects	Congenital Myasthenic Syndrome Due To Agrin Deficiency
Myasthenic Syndrome, Congenital, Due To Agrin Deficiency	Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects
Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects

Hypokalemia

Potassium Deficiency	Potassium Deficiency Disorder
Hypopotassemia	Potassium
Potassium [K] Deficiency	Hypokalaemic Syndrome
Hypopotassaemia	Hypopotassaemia Syndrome
Hypokalaemic	Potassium Depletion

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10	CMS10
Lgm	Myasthenia, Limb-Girdle, Familial
Myasthenia, Limb-Girdle, Familial, Formerly	Lgm, Formerly
Congenital Myasthenic Syndrome Type Ib, Formerly	Cms1b, Formerly
Cms Ib, Formerly	Myasthenic Myopathy, Formerly
Familial Limb-Girdle Myasthenia	Cms1b
Cms Ib	Congenital Myasthenic Syndrome Type 1b
Congenital Myasthenic Syndrome Type Ib	Myasthenic Myopathy
Myasthenic Syndrome, Congenital, Type 10	Congenital Myasthenic Syndrome Ib
Myopathy In Myasthenia Gravis

Progressive Familial Heart Block

Hereditary Bundle Branch Defect	Hereditary Bundle Branch System Defect
Familial Lenegre Disease	Familial Lev Disease
Familial Lev-Lenegre Disease	Familial Pccd
Familial Progressive Heart Block	Pfhb
Bundle Branch Block	Hbbd
Lenegre Lev Disease	Lev Syndrome
Lev'S Disease	Lev-Lenègre Disease
Pccd	Progressive Cardiac Conduction Defect
Bundle-Branch Block

Brain Glioblastoma Multiforme

Brain Glioblastoma	Glioblastoma Multiforme Of Brain
Glioblastoma Nos

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07152	KCNK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCNK1	MGD	MGI:109322
Bos taurus	KCNK1	VGNC	VGNC:30465
Rattus norvegicus	KCNK1	RGD	RGD:621447
Macaca mulatta	KCNK1	VGNC	VGNC:73993
Canis familiaris	KCNK1	VGNC	VGNC:51902

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