1. Gene
  2. CDIPT - CDP-diacylglycerol--inositol 3-phosphatidyltransferase Gene

CDIPT - CDP-diacylglycerol--inositol 3-phosphatidyltransferase Gene

Homo sapiens

Also known as PIS; PIS1

Gene ID: 10423 | Gene type: protein coding

About CDIPT

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,858,357-29,863,226 (from NCBI)

This gene has 10 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in ovary (RPKM 31.5), fat (RPKM 28.7) and 25 other tissues.

Summary

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two Enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

CDIPT Products(3)

mRNA Protein Name
NM_001286585.2 NP_001273514.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 2
NM_001286586.2 NP_001273515.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 3
NM_006319.5 NP_006310.1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA
IDA: Inferred from direct assay
8110188 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in phosphatidylinositol biosynthetic process IDA
IDA: Inferred from direct assay
8110188 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
8110188 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDIPT Protein Structure

CDP-OH_P_transf

CDP-OH_P_transf: CDP-alcohol phosphatidyltransferase (7 - 96)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

PI synthase

CDIPT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CDIPT O14735 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
CDIPT O14735 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
CDIPT O14735 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
CDIPT O14735 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
CDIPT O14735 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 RELL2 Homo sapiens Q8NC24
Validated Y2H
32296183
Intra
CDIPT O14735 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra
CDIPT O14735 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra
CDIPT O14735 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
CDIPT O14735 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
CDIPT O14735 CYB5R3 Homo sapiens P00387
Validated Y2H
32296183
Intra
CDIPT O14735 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 VMA21 Homo sapiens Q3ZAQ7
Validated Y2H
32296183
Intra
CDIPT O14735 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra
CDIPT O14735 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
CDIPT O14735 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
CDIPT O14735 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
CDIPT O14735 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
CDIPT O14735 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
Intra
CDIPT O14735 GPR151 Homo sapiens Q8TDV0
Validated Y2H
32296183
Intra
CDIPT O14735 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
CDIPT O14735 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
CDIPT O14735 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra
CDIPT O14735 PLP1 Homo sapiens P60201-2
Validated Y2H
32296183
Intra
CDIPT O14735 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
CDIPT O14735 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 ODF4 Homo sapiens Q2M2E3
Validated Y2H
32296183
Intra
CDIPT O14735 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 AQP2 Homo sapiens P41181
Validated Y2H
32296183
Intra
CDIPT O14735 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
CDIPT O14735 MS4A14 Homo sapiens Q96JA4
Validated Y2H
32296183
Intra
CDIPT O14735 MS4A14 Homo sapiens Q96JA4
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 MS4A14 Homo sapiens Q96JA4
Y2H Array
32296183
Intra
CDIPT O14735 ATP6V0E1 Homo sapiens O15342
Y2H Array
32296183
Intra
CDIPT O14735 ATP6V0E1 Homo sapiens O15342
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 ATP6V0E1 Homo sapiens O15342
Validated Y2H
32296183
Intra
CDIPT O14735 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
CDIPT O14735 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
CDIPT O14735 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
CDIPT O14735 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CDIPT O14735 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
CDIPT O14735 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
CDIPT O14735 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 UNC93A Homo sapiens Q86WB7-2
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 UNC93A Homo sapiens Q86WB7-2
Validated Y2H
32296183
Intra
CDIPT O14735 UNC93A Homo sapiens Q86WB7-2
Y2H Array
32296183
Intra
CDIPT O14735 FCGR2A Homo sapiens P12318-2
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 FCGR2A Homo sapiens P12318-2
Validated Y2H
32296183
Intra
CDIPT O14735 FCGR2A Homo sapiens P12318-2
Y2H Array
32296183
Intra
CDIPT O14735 GJB1 Homo sapiens P08034
Validated Y2H
32296183
Intra
CDIPT O14735 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
CDIPT O14735 SIGLEC12 Homo sapiens Q96PQ1
Y2H Array
32296183
Intra
CDIPT O14735 SIGLEC12 Homo sapiens Q96PQ1
Validated Y2H
32296183
Intra
CDIPT O14735 SIGLEC12 Homo sapiens Q96PQ1
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 EVI2B Homo sapiens P34910-2
Validated Y2H
32296183
Intra
CDIPT O14735 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
CDIPT O14735 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 GPR101 Homo sapiens Q96P66
Validated Y2H
32296183
Intra
CDIPT O14735 GPR101 Homo sapiens Q96P66
Y2H Array
32296183
Intra
CDIPT O14735 GPR101 Homo sapiens Q96P66
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
CDIPT O14735 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
CDIPT O14735 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
CDIPT O14735 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
CDIPT O14735 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
CDIPT O14735 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
CDIPT O14735 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CDIPT O14735 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
CDIPT O14735 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
CDIPT O14735 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
CDIPT O14735 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
CDIPT O14735 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
Intra
CDIPT O14735 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
CDIPT O14735 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 FFAR2 Homo sapiens O15552
Validated Y2H
32296183
Intra
CDIPT O14735 KCNK1 Homo sapiens O00180
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
CDIPT O14735 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
CDIPT O14735 DARS2 Homo sapiens Q6PI48
Y2H Array
32296183
Intra
CDIPT O14735 DARS2 Homo sapiens Q6PI48
Validated Y2H
32296183
Intra
CDIPT O14735 DARS2 Homo sapiens Q6PI48
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
CDIPT O14735 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
CDIPT O14735 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra
CDIPT O14735 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 SLC16A7 Homo sapiens O60669
Validated Y2H
32296183
Intra
CDIPT O14735 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
CDIPT O14735 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
CDIPT O14735 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra
CDIPT O14735 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
CDIPT O14735 SCAI Homo sapiens Q8N9R8
Validated Y2H
32296183
Intra
CDIPT O14735 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
CDIPT O14735 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
CDIPT O14735 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
CDIPT O14735 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra
CDIPT O14735 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 MGST3 Homo sapiens O14880
Validated Y2H
32296183
Intra
CDIPT O14735 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
CDIPT O14735 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Intra
CDIPT O14735 IER3IP1 Homo sapiens Q9Y5U9
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 IER3IP1 Homo sapiens Q9Y5U9
Y2H Array
32296183
Intra
CDIPT O14735 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
CDIPT O14735 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
CDIPT O14735 RTN3 Homo sapiens O95197
Validated Y2H
25416956
Intra
CDIPT O14735 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra
CDIPT O14735 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
CDIPT O14735 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CDIPT O14735 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
CDIPT O14735 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 BSND Homo sapiens Q8WZ55
Y2H Array
32296183
Intra
CDIPT O14735 BSND Homo sapiens Q8WZ55
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 BSND Homo sapiens Q8WZ55
Validated Y2H
32296183
Intra
CDIPT O14735 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
CDIPT O14735 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra
CDIPT O14735 CYB561 Homo sapiens P49447
Validated Y2H
32296183
Intra
CDIPT O14735 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
CDIPT O14735 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 IGFBP6 Homo sapiens P24592
Y2H Prey Pooling
32296183
Intra
CDIPT O14735 IGFBP6 Homo sapiens P24592
Validated Y2H
32296183
Intra
CDIPT O14735 IGFBP6 Homo sapiens P24592
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Alpha-1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency

Alpha-1 Antitrypsin Deficiency

Aat Deficiency

Aatd

A1ATD

Emphysema Due To Aat Deficiency

A1at Deficiency

Emphysema-Cirrhosis, Due To Aat Deficiency

Hemorrhagic Diathesis Due To Antithrombin Pittsburgh

Alpha-1 Antiprotease Deficiency

Alpha 1 Antitrypsin Deficiency

Aat

Alpha-1 Protease Inhibitor Deficiency

Alpha-1 Related Emphysema

Genetic Emphysema

Hereditary Pulmonary Emphysema

Inherited Emphysema

Alpha-1-Proteinase Inhibitor Deficiency

Alpha1-Antitrypsin Deficiency

Alpha-1-Antitrypsin Deficiency, Autosomal Recessive

Emphysema, Hereditary Pulmonary

Aatd - [Alpha-1-Antitrypsin] Deficiency

Byssinosis

Flax-Dressers' Disease

Cotton Mill Fever

Stripper'S Asthma

Monday Morning Fever

Cotton Workers' Lung Disease

Cotton-Dust Asthma

Mill Fever

Lung Fibrosis With Byssinosis

Airway Disease Due To Cotton Dust

Respiratory Tract Disorder Due To Cotton Dust

Strippers' Disease

Flax-Dressers' Disorder

Strippers' Asthma

Plasma Protein Metabolism Disease
Fibromuscular Dysplasia
Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome

Shah-Waardenburg Syndrome

Waardenburg Syndrome Type 4a

WS4A

Ws4

Waardenburg Syndrome Type 4

Waardenburg Syndrome Type Iva

Waardenburg Syndrome With Hirschsprung Disease Type 4a

Hirschsprung Disease With Pigmentary Anomaly

Waardenburg-Hirschsprung Syndrome

Waardenburg Syndrome, Type Iva

Waardenburg Syndrome With Hirschsprung Disease, Type 4a

Waardenburg-Hirschsprung Disease

Waardenburg Syndrome, Type 4

Waardenburg Syndrome 4a

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus CDIPT MGD MGI:105491
Bos taurus CDIPT VGNC VGNC:27114
Felis catus CDIPT VGNC VGNC:60692
Rattus norvegicus CDIPT RGD RGD:620576
Macaca mulatta CDIPT VGNC VGNC:70978
Canis familiaris CDIPT VGNC VGNC:54010