IPO5 - importin 5 Gene

Homo sapiens

Also known as IMB3; Pse1; imp5; KPNB3; RANBP5

Gene ID: 3843 | Gene type: protein coding

About IPO5

Cytogenetic location: 13q32.2 Genomic coordinates (GRCh38): 13:97,953,675-98,024,296 (from NCBI)

This gene has 30 transcripts (splice variants), 219 orthologues and 5 paralogues. Broad expression in testis (RPKM 84.9), ovary (RPKM 29.9) and 25 other tissues.

Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

IPO5 Products(1)

mRNA	Protein	Name
NM_002271.6	NP_002262.4	importin-5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	31340999	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10799599	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	31340999	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	31340999	GOA
involved in ribosomal protein import into nucleus	IDA IDA: Inferred from direct assay	9687515	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IPO5 Protein Structure

HEAT_2

HEAT

0
200
400
600
800
1000
1097 a.a.

Protein Preferred Names

Protein Names

importin-5

Kap beta3 import receptor

IPO5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IPO5	O00410	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	IPO5	O00410	RPL7	Homo sapiens	P18124	Filter Binding	20828572
Intra	IPO5	O00410	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	IPO5	O00410	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	IPO5	O00410	ACD	Homo sapiens	Q96AP0	BiFC	21044950
Intra	IPO5	O00410	ACD	Homo sapiens	Q96AP0	Pull Down	21044950
Intra	IPO5	O00410	GABARAPL2	Homo sapiens	P60520	Anti Tag CoIP	33961781
Intra	IPO5	O00410	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	IPO5	O00410	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Cross	IPO5	O00410	P27958-PRO_0000037576	Hepatitis C virus	P27958-PRO_0000037576	Y2H	10799599
Cross	IPO5	O00410	P27958-PRO_0000037576	Hepatitis C virus	P27958-PRO_0000037576	Anti Tag CoIP	10799599

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Brittle Cornea Syndrome 1

Brittle Cornea Syndrome	Fragilitas Oculi With Joint Hyperextensibility
Dysgenesis Mesodermalis Corneae Et Sclerae	BCS1
Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility	Ehlers-Danlos Syndrome, Type Vib, Formerly
Eds6b, Formerly	Type Vib Ehlers-Danlos Syndrome
Eds Vib	Ehlers-Danlos Syndrome Type 6b
Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility	Eds6b Formerly
Ehlers-Danlos Syndrome Type Vib Formerly	Ehlers-Danlos Syndrome Type 6
Cornea, Brittle, Syndrome	Cornea, Brittle, Syndrome, Type 1
Ehlers-Danlos Syndrome 6b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06869	IPO5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IPO5	VGNC	VGNC:30243
Felis catus	IPO5	VGNC	VGNC:67981
Mus musculus	IPO5	MGD	MGI:1917822
Rattus norvegicus	IPO5	RGD	RGD:1308715
Macaca mulatta	IPO5	VGNC	VGNC:73813
Canis familiaris	IPO5	VGNC	VGNC:42066

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