INSC - INSC spindle orientation adaptor protein Gene

Homo sapiens

Gene ID: 387755 | Gene type: protein coding

About INSC

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:15,111,416-15,269,676 (from NCBI)

This gene has 8 transcripts (splice variants) and 198 orthologues. Low expression observed in reference dataset.

Summary

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

INSC Products(6)

mRNA	Protein	Name
NM_001031853.5	NP_001027024.3	protein inscuteable homolog isoform a
NM_001042536.3	NP_001036001.1	protein inscuteable homolog isoform b
NM_001278313.2	NP_001265242.1	protein inscuteable homolog isoform b
NM_001278314.2	NP_001265243.1	protein inscuteable homolog isoform c
NM_001278315.2	NP_001265244.1	protein inscuteable homolog isoform d
NM_001278316.2	NP_001265245.1	protein inscuteable homolog isoform e

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16458856	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	22074847	GOA
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	16458856	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	22074847	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with cell cortex	IMP IMP: Inferred from mutant phenotype	22074847	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	22074847	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	16458856	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	22074847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein inscuteable homolog

inscuteable homolog

INSC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	INSC	Q1MX18	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
Intra	INSC	Q1MX18	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	INSC	Q1MX18	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	INSC	Q1MX18	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	INSC	Q1MX18	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	INSC	Q1MX18	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	INSC	Q1MX18	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	INSC	Q1MX18	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	INSC	Q1MX18	GPSM2	Homo sapiens	P81274	Y2H Array	32296183
Intra	INSC	Q1MX18	GPSM2	Homo sapiens	P81274	Anti Tag CoIP	33961781
Intra	INSC	Q1MX18	GPSM2	Homo sapiens	P81274	Y2H Prey Pooling	32296183
Intra	INSC	Q1MX18	RUSC1	Homo sapiens	Q9BVN2	Y2H Prey Pooling	32296183
Intra	INSC	Q1MX18	RUSC1	Homo sapiens	Q9BVN2	Validated Y2H	32296183
Intra	INSC	Q1MX18	RUSC1	Homo sapiens	Q9BVN2	Y2H Array	32296183
Intra	INSC	Q1MX18	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	INSC	Q1MX18	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	INSC	Q1MX18	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	INSC	Q1MX18	TEKT3	Homo sapiens	Q9BXF9	Validated Y2H	32296183
Intra	INSC	Q1MX18	TTC23	Homo sapiens	Q5W5X9-3	Y2H Array	32296183
Intra	INSC	Q1MX18	TTC23	Homo sapiens	Q5W5X9-3	Y2H Prey Pooling	32296183
Intra	INSC	Q1MX18	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145758	FEN1-IN-SC13	Inhibitor	98.21%	Unkown
HY-131236	EBNA1-IN-SC7		99.92%	Unkown
HY-RS06836	INSC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	INSC	RGD	RGD:1311379
Bos taurus	INSC	VGNC	VGNC:30216
Macaca mulatta	INSC	VGNC	VGNC:73693
Mus musculus	INSC	MGD	MGI:1917942
Canis familiaris	INSC	VGNC	VGNC:42038
Felis catus	INSC	VGNC	VGNC:62932

Name
Email *

	Sorry, but the email address you supplied was invalid.