Gfral - GDNF family receptor alpha like Gene

Mus musculus

Also known as Gral

Gene ID: 404194 | Gene type: protein coding

About Gfral

Summary

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in positive regulation of MAPK cascade and reduction of food intake in response to dietary excess. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Located in plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Apr 2022]

Gfral Products(1)

mRNA	Protein	Name
NM_205844.4	NP_995316.2	GDNF family receptor alpha-like precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glial cell-derived neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	28846097	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28846098	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	28846099	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in GDF15-GFRAL signaling pathway	IDA IDA: Inferred from direct assay	32723474	MGI
involved in GDF15-GFRAL signaling pathway	IMP IMP: Inferred from mutant phenotype	31875646	MGI
involved in negative regulation of appetite	IDA IDA: Inferred from direct assay	32723474	MGI
involved in negative regulation of appetite	IMP IMP: Inferred from mutant phenotype	31875646	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	16086688	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16086688	MGI
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	28953886	MGI
involved in reduction of food intake in response to dietary excess	IDA IDA: Inferred from direct assay	28846097	MGI
involved in reduction of food intake in response to dietary excess	IMP IMP: Inferred from mutant phenotype	28846098	MGI
involved in response to metformin	IMP IMP: Inferred from mutant phenotype	31875646	MGI
acts upstream of or within stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	16086688	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16086688	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GDNF family receptor alpha-like

GDNF receptor alpha-like

Recombinant Gfral Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77947	GFRAL Protein, Mouse (HEK293, His-Avi)	Q6SJE0-1 (Q20-E350)	≥95%
HY-P700449	GFRAL Protein, Mouse (HEK293, His-Myc)	Q6SJE0-1 (Q20-G349)	≥95%
HY-P700728	GFRAL Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q6SJE0-1 (Q20-E350)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99241	Ponsegromab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05390	GFRAL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gfral	NCBI	NCBI:389400
Macaca fascicularis	Gfral	NCBI	NCBI:102126381
Rattus norvegicus	Gfral	NCBI	NCBI:501023

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