MAP2 - microtubule associated protein 2 Gene

Homo sapiens

Also known as MAP-2; MAP2A; MAP2B; MAP2C

Gene ID: 4133 | Gene type: protein coding

About MAP2

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:209,424,047-209,734,112 (from NCBI)

This gene has 19 transcripts (splice variants), 274 orthologues and 1 paralogue. Biased expression in brain (RPKM 82.4), thyroid (RPKM 4.7) and 1 other tissue.

Summary

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

MAP2 Products(58)

mRNA	Protein	Name
NM_001039538.2	NP_001034627.1	microtubule-associated protein 2 isoform 5
NM_001363910.2	NP_001350839.1	microtubule-associated protein 2 isoform 6
NM_001363911.2	NP_001350840.1	microtubule-associated protein 2 isoform 6
NM_001363913.2	NP_001350842.1	microtubule-associated protein 2 isoform 2
NM_001375474.1	NP_001362403.1	microtubule-associated protein 2 isoform 24
NM_001375493.1	NP_001362422.1	microtubule-associated protein 2 isoform 2
NM_001375494.1	NP_001362423.1	microtubule-associated protein 2 isoform 30
NM_001375495.1	NP_001362424.1	microtubule-associated protein 2 isoform 20
NM_001375496.1	NP_001362425.1	microtubule-associated protein 2 isoform 25
NM_001375497.1	NP_001362426.1	microtubule-associated protein 2 isoform 27
NM_001375498.1	NP_001362427.1	microtubule-associated protein 2 isoform 19
NM_001375499.1	NP_001362428.1	microtubule-associated protein 2 isoform 4
NM_001375500.1	NP_001362429.1	microtubule-associated protein 2 isoform 18
NM_001375501.1	NP_001362430.1	microtubule-associated protein 2 isoform 8
NM_001375502.1	NP_001362431.1	microtubule-associated protein 2 isoform 13
NM_001375503.1	NP_001362432.1	microtubule-associated protein 2 isoform 11
NM_001375504.1	NP_001362433.1	microtubule-associated protein 2 isoform 7
NM_001375505.1	NP_001362434.1	microtubule-associated protein 2 isoform 1
NM_001375506.1	NP_001362435.1	microtubule-associated protein 2 isoform 12
NM_001375507.1	NP_001362436.1	microtubule-associated protein 2 isoform 14
NM_001375508.1	NP_001362437.1	microtubule-associated protein 2 isoform 4
NM_001375509.1	NP_001362438.1	microtubule-associated protein 2 isoform 23
NM_001375510.1	NP_001362439.1	microtubule-associated protein 2 isoform 20
NM_001375526.1	NP_001362455.1	microtubule-associated protein 2 isoform 1
NM_001375527.1	NP_001362456.1	microtubule-associated protein 2 isoform 12
NM_001375528.1	NP_001362457.1	microtubule-associated protein 2 isoform 6
NM_001375529.1	NP_001362458.1	microtubule-associated protein 2 isoform 27
NM_001375530.1	NP_001362459.1	microtubule-associated protein 2 isoform 36
NM_001375531.1	NP_001362460.1	microtubule-associated protein 2 isoform 9
NM_001375532.1	NP_001362461.1	microtubule-associated protein 2 isoform 36
NM_001375533.1	NP_001362462.1	microtubule-associated protein 2 isoform 27
NM_001375534.1	NP_001362463.1	microtubule-associated protein 2 isoform 1
NM_001375535.1	NP_001362464.1	microtubule-associated protein 2 isoform 22
NM_001375536.1	NP_001362465.1	microtubule-associated protein 2 isoform 20
NM_001375537.1	NP_001362466.1	microtubule-associated protein 2 isoform 8
NM_001375538.1	NP_001362467.1	microtubule-associated protein 2 isoform 21
NM_001375539.1	NP_001362468.1	microtubule-associated protein 2 isoform 10
NM_001375540.1	NP_001362469.1	microtubule-associated protein 2 isoform 35
NM_001375541.1	NP_001362470.1	microtubule-associated protein 2 isoform 26
NM_001375542.1	NP_001362471.1	microtubule-associated protein 2 isoform 28
NM_001375543.1	NP_001362472.1	microtubule-associated protein 2 isoform 31
NM_001375544.1	NP_001362473.1	microtubule-associated protein 2 isoform 13
NM_001375545.1	NP_001362474.1	microtubule-associated protein 2 isoform 14
NM_001375546.1	NP_001362475.1	microtubule-associated protein 2 isoform 32
NM_001375548.1	NP_001362477.1	microtubule-associated protein 2 isoform 33
NM_001375551.1	NP_001362480.1	microtubule-associated protein 2 isoform 16
NM_001375552.1	NP_001362481.1	microtubule-associated protein 2 isoform 16
NM_001375553.1	NP_001362482.1	microtubule-associated protein 2 isoform 29
NM_001375554.1	NP_001362483.1	microtubule-associated protein 2 isoform 29
NM_001375555.1	NP_001362484.1	microtubule-associated protein 2 isoform 15
NM_001375556.1	NP_001362485.1	microtubule-associated protein 2 isoform 16
NM_001375557.1	NP_001362486.1	microtubule-associated protein 2 isoform 16
NM_001375558.1	NP_001362487.1	microtubule-associated protein 2 isoform 17
NM_001375559.1	NP_001362488.1	microtubule-associated protein 2 isoform 34
NM_001375583.1	NP_001362512.1	microtubule-associated protein 2 isoform 2
NM_002374.4	NP_002365.3	microtubule-associated protein 2 isoform 1
NM_031845.3	NP_114033.2	microtubule-associated protein 2 isoform 2
NM_031847.3	NP_114035.2	microtubule-associated protein 2 isoform 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables dystroglycan binding	IPI IPI: Inferred from physical interaction	18341635	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in central nervous system neuron development	IEP IEP: Inferred from expression pattern	20846339	GOA
involved in dendrite morphogenesis	IEP IEP: Inferred from expression pattern	20846339	GOA
involved in neuron projection development	IEP IEP: Inferred from expression pattern	20846339	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP2 Protein Structure

MAP2_projctn

Tubulin-binding

0
300
600
900
1200
1500
1827 a.a.

Protein Preferred Names

Protein Names

microtubule-associated protein 2

Related Diseases

Diseases

Alias

Central Neurocytoma

Neurocytoma	Neurolipocytoma
Neurocytoma Central

Olivopontocerebellar Atrophy

Thomas Syndrome	Olivopontocerebellar Atrophies
Dejerine-Thomas Syndrome	Thomas' Syndrome
Wadia-Swami Syndrome	Opca
Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome	Spinocerebellar Ataxia Type 2

Ganglioglioma

Childhood Ganglioglioma	Adult Ganglioglioma
Cns Ganglioglioma	Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components

Merkel Cell Carcinoma

Trabecular Adenocarcinoma	Cutaneous Neuroendocrine Carcinoma
Trabecular Carcinoma	Carcinoma, Merkel Cell
Merkel Cell Cancer	Merkle Tumors
Mcc	Carcinoma Merkel Cell

Striatonigral Degeneration

Ischemia

Acute Coronary Syndrome

Transient Cerebral Ischemia

Transient Ischemic Attack	Transient Ischemic Attacks
Tia	Tia - Transient Ischaemic Attack
Transient Cerebral Ischaemia	Ischemic Attack, Transient
Intermittent Cerebral Ischemia	Tia - [Transient Ischaemic Attack]
Intermittent Cerebral Ischaemia	Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Scrapie

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis	Hme
Human Ehrlichial Infection, Human Monocytic Type

Teratoma

Teratomas

Chiari Malformation

Occlusion Precerebral Artery

Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries

Occlusion And Stenosis Of Precerebral Artery

Multiple System Atrophy 1

Multiple System Atrophy	Shy-Drager Syndrome
Msa	MSA1
Multiple System Atrophy 1, Susceptibility To	Sporadic Olivopontocerebellar Atrophy
Multisystem Atrophy	Msa1, Susceptibility To
Multiple System Atrophy, Susceptibility To	Opca
Progressive Autonomic Failure With Multiple System Atrophy	Sds

Cerebellar Liponeurocytoma

Lipomatous Medulloblastoma

Central Neurocytoma

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Carotid Artery Occlusion

Occlusion And Stenosis Of Carotid Artery

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Toxic Encephalopathy

Neurotoxicity	Neurotoxicity Syndromes
Neurotoxicity Syndrome	Encephalopathy, Toxic

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-107116	MAP4343		98.09%	Phase 2

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-159190	HRX-0233	Inhibitor	/	Unkown
HY-RS16235	Map2k4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-107116S	MAP4343-d4		/	Unkown
HY-163880	EGFR-IN-119	Inhibitor	/	Unkown
HY-P3894	P34cdc2 Kinase Fragment	Modulator	/	Unkown
HY-RS08032	MAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08033	MAP2K1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08034	Map2k1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08035	Map2k1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08036	MAP2K2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08037	Map2k2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08038	Map2k2 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08039	MAP2K3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08040	MAP2K4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08044	MAP2K6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08045	MAP2K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MAP2	VGNC	VGNC:42959
Mus musculus	MAP2	MGD	MGI:97175
Bos taurus	MAP2	VGNC	VGNC:31182
Macaca mulatta	MAP2	VGNC	VGNC:74491
Rattus norvegicus	MAP2	RGD	RGD:3044
Felis catus	MAP2	VGNC	VGNC:68153
Others	MAP2	NCBI