2. MAPK/ERK Pathway
  3. MAPKAPK2 (MK2)
  4. HRX-0233

HRX-0233 is a small-molecule MAP2K4 inhibitor. HRX-0233 results in strong tumor shrinkage without any apparent toxicity in H358 KRASG12C-mutant non-small cell lung cancers (NSCLC) in vivo. HRX-0233 efficiently prevents feedback activation of receptor tyrosine kinases (RTKs) upon monotherapy KRAS inhibitor Sotorasib (HY-114277) and causes a more sustained and complete inhibition of MAPK signaling. HRX-0233 is promising for research of AR-negative prostate cancer, lung and colon cancers.

For research use only. We do not sell to patients.

HRX-0233 Chemical Structure

HRX-0233 Chemical Structure

CAS No. : 2409140-12-9

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Based on 1 publication(s) in Google Scholar

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Description

HRX-0233 is a small-molecule MAP2K4 inhibitor. HRX-0233 results in strong tumor shrinkage without any apparent toxicity in H358 KRASG12C-mutant non-small cell lung cancers (NSCLC) in vivo. HRX-0233 efficiently prevents feedback activation of receptor tyrosine kinases (RTKs) upon monotherapy KRAS inhibitor Sotorasib (HY-114277) and causes a more sustained and complete inhibition of MAPK signaling. HRX-0233 is promising for research of AR-negative prostate cancer, lung and colon cancers[1][2].

Molecular Weight

497.52

Formula

C24H21F2N5O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CNC2=NC=C(C3=CN=C(C4CC4)N=C3)C=C21)C5=CC=C(C(NS(=O)(CCC)=O)=C5F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 17.5 mg/mL (35.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0100 mL 10.0498 mL 20.0997 mL
5 mM 0.4020 mL 2.0100 mL 4.0199 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0100 mL 10.0498 mL 20.0997 mL 50.2492 mL
5 mM 0.4020 mL 2.0100 mL 4.0199 mL 10.0498 mL
10 mM 0.2010 mL 1.0050 mL 2.0100 mL 5.0249 mL
15 mM 0.1340 mL 0.6700 mL 1.3400 mL 3.3499 mL
20 mM 0.1005 mL 0.5025 mL 1.0050 mL 2.5125 mL
25 mM 0.0804 mL 0.4020 mL 0.8040 mL 2.0100 mL
30 mM 0.0670 mL 0.3350 mL 0.6700 mL 1.6750 mL
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HRX-0233 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HRX-02332409140-12-9HRX0233HRX 0233MAPKAPK2 (MK2)Mitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2MAP2K4tumor shrinkageRTKslung cancerscolon cancersInhibitorinhibitorinhibit

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