BODIPY-FL staurosporine 

BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery^[1].

901.80

C₄₉H₅₄BF₂N₇O₇

2411845-57-1

C[C@]12N3C4=C(C5=CC=CC=C53)C(CNC6=O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NCCOCCOCCOCCNC(CCC8=CC=C(C=C9C(C)=C%10)[N-]8[B+3]([F-])([F-])[N]9=C%10C)=O)([H])O1)C%11=CC=CC=C7%11

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hirozane Y, et al. Structure-based rational design of staurosporine-based fluorescent probe with broad-ranging kinase affinity for kinase panel application[J]. Bioorganic & medicinal chemistry letters, 2019, 29(21): 126641.  [Content Brief]