MARK1 - microtubule affinity regulating kinase 1 Gene

Homo sapiens

Also known as MARK; Par1c; Par-1c

Gene ID: 4139 | Gene type: protein coding

About MARK1

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,528,136-220,664,461 (from NCBI)

This gene has 18 transcripts (splice variants), 230 orthologues and 3 paralogues. Broad expression in brain (RPKM 4.9), testis (RPKM 3.5) and 21 other tissues.

Summary

Enables several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MARK1 Products(5)

mRNA	Protein	Name
NM_001286124.2	NP_001273053.1	serine/threonine-protein kinase MARK1 isoform 1
NM_001286126.2	NP_001273055.1	serine/threonine-protein kinase MARK1 isoform 3
NM_001286128.2	NP_001273057.1	serine/threonine-protein kinase MARK1 isoform 4
NM_001286129.2	NP_001273058.1	serine/threonine-protein kinase MARK1 isoform 5
NM_018650.5	NP_061120.3	serine/threonine-protein kinase MARK1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	21145462	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	21145462	GOA
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	21145462	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23666762	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14976552	GOA
enables tau-protein kinase activity	IMP IMP: Inferred from mutant phenotype	23666762	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	14976552	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	31281935	GOA
acts upstream of negative regulation of gene expression	IDA IDA: Inferred from direct assay	31281935	GOA
acts upstream of positive regulation of gene expression	IDA IDA: Inferred from direct assay	31281935	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14976552	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23666762	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23666762	GOA
located in dendrite	IDA IDA: Inferred from direct assay	23666762	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21145462	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARK1 Protein Structure

Pkinase

KA1

0
200
400
600
795 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase MARK1

MAP/microtubule affinity-regulating kinase 1

Related Diseases

Diseases

Alias

Peutz-Jeghers Syndrome

PJS	Polyposis, Hamartomatous Intestinal
Polyps-And-Spots Syndrome	Lentiginosis, Perioral
Periorificial Lentiginosis Syndrome	Hamartomatous Intestinal Polyposis
Hamartomatous Polyp	Colonic Hamartomatous Polyp
Gastric Peutz-Jeghers Polyp	Peutz Jeghers Colon Polyp
Peutz Jeghers Polyp	Peutz-Jeghers Polyp Of Small Intestine
Peutz-Jeghers Small Bowel Hamartoma	Peutz Jeghers Polyposis
Intestinal Polyposis-Cutaneous Pigmentation Syndrome	Peutz-Jeghers Polyposis
Polyposis, Intestinal, Ii	Intestinal Hamartomatous Polyposis
Peutz-Jeghers Polyp	Peutz-Jeghers Polyp Of The Stomach
Peutz Jehgers Polyp	Peutz-Jeghers Polyps Of Small Bowel

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120877	MRT199665		99.74%	Unkown
HY-139604	PCC0208017		98.03%	Unkown
HY-120877A	(R)-MRT199665		98.70%	Unkown
HY-RS08149	MARK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MARK1	RGD	RGD:619882
Canis familiaris	MARK1	VGNC	VGNC:49921
Felis catus	MARK1	VGNC	VGNC:68184
Macaca mulatta	MARK1	VGNC	VGNC:74658
Mus musculus	MARK1	MGD	MGI:2664902
Bos taurus	MARK1	VGNC	VGNC:103721
Others	MARK1	NCBI

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