MAT1A - methionine adenosyltransferase 1A Gene

Homo sapiens

Also known as MAT; SAMS; MATA1; SAMS1

Gene ID: 4143 | Gene type: protein coding

About MAT1A

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:80,271,820-80,289,658 (from NCBI)

This gene has 4 transcripts (splice variants), 251 orthologues, 1 paralogue and is associated with 3 phenotypes. Restricted expression toward liver (RPKM 313.0).

Summary

This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

MAT1A Products(1)

mRNA	Protein	Name
NM_000429.3	NP_000420.1	S-adenosylmethionine synthase isoform type-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables methionine adenosyltransferase activity	IDA IDA: Inferred from direct assay	10677294	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in S-adenosylmethionine biosynthetic process	IDA IDA: Inferred from direct assay	25075345	GOA
involved in S-adenosylmethionine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10677294	GOA
involved in methionine catabolic process	IMP IMP: Inferred from mutant phenotype	10677294	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	23425511	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of methionine adenosyltransferase complex	IPI IPI: Inferred from physical interaction	25075345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAT1A Protein Structure

S-AdoMet_synt_N

S-AdoMet_synt_M

S-AdoMet_synt_C

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

S-adenosylmethionine synthase isoform type-1

MAT 1

MAT1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Anti Tag CoIP	33961781
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Y2H Prey Pooling	32296183
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Anti Tag CoIP	28514442
Intra	MAT1A	Q00266	MAT2A	Homo sapiens	P31153	Y2H Array	32296183
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Y2H Array	32296183
Intra	MAT1A	Q00266	MAT2B	Homo sapiens	Q9NZL9-2	Anti Tag CoIP	28514442
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Y2H Prey Pooling	32296183
Intra	MAT1A	Q00266	ASPSCR1	Homo sapiens	Q9BZE9-2	Anti Tag CoIP	28514442
Intra	MAT1A	Q00266	MAT2B	Homo sapiens	Q9NZL9	Anti Tag CoIP	33961781
Intra	MAT1A	Q00266	ASPSCR1	Homo sapiens	Q9BZE9	Anti Tag CoIP	33961781
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Validated Y2H	32296183
Intra	MAT1A	Q00266	MAT1A	Homo sapiens	Q00266	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

MAT1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83454	MAT1A Antibody (YA3199)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Methionine Adenosyltransferase I/Iii Deficiency

Mat I/Iii Deficiency	Mat Deficiency
Methionine Adenosyltransferase Deficiency, Autosomal Recessive	Hypermethioninemia, Persistent, Autosomal Dominant, Due To Methionine Adenosyltransferase I/Iii Deficiency
Methionine Adenosyltransferase Deficiency	Hypermethioninemia, Isolated Persistent
Brain Demyelination Due To Methionine Adenosyltransferase Deficiency	MATD
Isolated Persistent Hypermethioninemia	Hepatic Methionine Adenosyltransferase Deficiency
Deficiency Of Acetyl-Coa Acetyltransferase

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency	Deficiency Of Methionine Adenosyltransferase
Glycine N-Methyltransferase Deficiency	Met
S-Adenosylhomocysteine Hydrolase Deficiency	Gnmt Deficiency
Mat Deficiency	Methionine Adenosyltransferase Deficiency
Methioninemia	Deficiency Of Acetyl-Coa Acetyltransferase

Methionine Adenosyltransferase Deficiency

Mat Deficiency	Hepatic Methionine Adenosyltransferase Deficiency
Deficiency Of Acetyl-Coa Acetyltransferase

Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY	Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency
Hypermethioninemia Due To Gnmt Deficiency	Hypermethioninemia
Hepatic Methionine Adenosyltransferase Deficiency

Alpha-Methylacetoacetic Aciduria

Beta-Ketothiolase Deficiency	3-Ketothiolase Deficiency
3-Oxothiolase Deficiency	Mitochondrial Acetoacetyl-Coa Thiolase Deficiency
Alpha-Methylacetoaceticaciduria	Mat Deficiency
T2 Deficiency	2-Methyl-3-Hydroxybutyricacidemia
Beta Ketothiolase Deficiency	Pseudo-Zellweger Syndrome
2-Methyl-3-Hydroxybutyric Acidemia	3-Ktd Deficiency
Peroxisomal Thiolase Deficiency	2-Methylacetoacetyl-Coenzyme A Thiolase Deficiency
3-Alpha-Oxothiolase Deficiency	Methylacetoacetyl-Coenzyme A Thiolase Deficiency
Mitochondrial 2-Methylacetoacetyl-Coa Thiolase Deficiency - Potassium Stimulated	Β-Ketothiolase Deficiency
Alpha Methylacetoacetic Aciduria	Alpha-Methyl-Acetoacetyl-Coa Thiolase Deficiency
Mitochondrial Acetoacetyl-Coenzyme A Thiolase Deficiency	3KTD
Aciduria, Alpha-Methylacetoacetic	Deficiency Of Acetyl-Coa Acetyltransferase
Deficiency Of Acetyl-Coa Acyltransferase	Hepatic Methionine Adenosyltransferase Deficiency
Bifunctional Peroxisomal Enzyme Deficiency

Homocystinuria

Cystathionine Beta Synthase Deficiency	Homocysteinemia
Cbs Deficiency	Cystathionine Synthase Deficiency
Cystathionine Beta-Synthase Deficiency Disease

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Intestinal Disaccharidase Deficiency

Disaccharidase Deficiency

Clear Cell Acanthoma

Acanthoma	Pale Acanthoma
Acanthoma, Clear Cell

Mend Syndrome

Male Ebp Disorder With Neurological Defects	MEND
Male Ebp Disorder With Neurologic Defects

Tyrosinemia, Type I

Tyrosinemia Type I	Hepatorenal Tyrosinemia
Fumarylacetoacetase Deficiency	Fah Deficiency
TYRSN1	Fumarylacetoacetate Hydrolase Deficiency
Tyrosinemia Type 1	Tyrosinemia 1
Fumarylacetoacetase

Histidinemia

Histidine Ammonia-Lyase Deficiency	Hal Deficiency
Histidase Deficiency	His Deficiency
Histidinuria	Hyperhistidinemia
HISTID	Histidinuria Renal Tubular Defect

Histidine Metabolism Disease

Disturbances Of Histidine Metabolism	Disorder Of Histidine Metabolism
Disturbance Of Histidine Metabolism

Hyperprolinemia, Type I

Proline Oxidase Deficiency	Hyperprolinemia Type 1
HYRPRO1	Hpi
Hyperprolinemia Type I	Hyperprolinemia 1
Proline Dehydrogenase Deficiency

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Alkaptonuria

Homogentisic Acid Oxidase Deficiency	Alcaptonuria
AKU	Deficiency Of Homogentisicase
Homogentisate 1,2-Dioxygenase Deficiency	Alkaptonuric Ochronosis
Homogentisic Acidura	Ochronosis, Hereditary
Hereditary Ochronosis	Ochronosis
Homogentisicaciduria	Deficiency Of Homogentisate Oxygenase

Amino Acid Metabolic Disorder

Amino Acid Metabolism, Inborn Errors	Inborn Errors Of Amino Acid Metabolism
Disorder Of Amino Acid Metabolism	Amino Acid Metabolism Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08166	MAT1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAT1A	VGNC	VGNC:31261
Macaca mulatta	MAT1A	VGNC	VGNC:74663
Canis familiaris	MAT1A	VGNC	VGNC:43037
Felis catus	MAT1A	VGNC	VGNC:68192
Rattus norvegicus	MAT1A	RGD	RGD:3050
Mus musculus	MAT1A	MGD	MGI:88017

Name
Email *

	Sorry, but the email address you supplied was invalid.