2. Gene
  3. MLF1 - myeloid leukemia factor 1 Gene

MLF1 - myeloid leukemia factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 4291 | Gene type: protein coding

About MLF1

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,571,194-158,606,456 (from NCBI)

This gene has 21 transcripts (splice variants), 192 orthologues, 1 paralogue and is associated with 55 phenotypes. Biased expression in testis (RPKM 97.9), heart (RPKM 24.2) and 4 other tissues.

Summary

This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

MLF1 Products(20)

mRNA Protein Name
NM_001130156.3 NP_001123628.1 myeloid leukemia factor 1 isoform 2
NM_001130157.3 NP_001123629.1 myeloid leukemia factor 1 isoform 2
NM_001195432.4 NP_001182361.2 myeloid leukemia factor 1 isoform 5
NM_001195433.2 NP_001182362.1 myeloid leukemia factor 1 isoform 4
NM_001195434.2 NP_001182363.1 myeloid leukemia factor 1 isoform 5
NM_001369781.1 NP_001356710.1 myeloid leukemia factor 1 isoform 7
NM_001369782.1 NP_001356711.1 myeloid leukemia factor 1 isoform 8
NM_001369783.1 NP_001356712.1 myeloid leukemia factor 1 isoform 6
NM_001369784.1 NP_001356713.1 myeloid leukemia factor 1 isoform 2
NM_001369785.1 NP_001356714.1 myeloid leukemia factor 1 isoform 5
NM_001378845.1 NP_001365774.1 myeloid leukemia factor 1 isoform 9
NM_001378846.1 NP_001365775.1 myeloid leukemia factor 1 isoform 5
NM_001378847.1 NP_001365776.1 myeloid leukemia factor 1 isoform 2
NM_001378848.1 NP_001365777.1 myeloid leukemia factor 1 isoform 2
NM_001378850.1 NP_001365779.1 myeloid leukemia factor 1 isoform 10
NM_001378851.1 NP_001365780.1 myeloid leukemia factor 1 isoform 11
NM_001378852.1 NP_001365781.1 myeloid leukemia factor 1 isoform 12
NM_001378853.1 NP_001365782.1 myeloid leukemia factor 1 isoform 13
NM_001378855.1 NP_001365784.1 myeloid leukemia factor 1 isoform 14
NM_022443.5 NP_071888.1 myeloid leukemia factor 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12176995 GOA
enables protein domain specific binding IDA
IDA: Inferred from direct assay
12176995 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of negative effect regulation of cell cycle G1/S phase transition IPI
IPI: Inferred from physical interaction
15861129 GOA
acts upstream of positive effect regulation of signal transduction by p53 class mediator IPI
IPI: Inferred from physical interaction
15861129 GOA
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15861129 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLF1 Protein Structure

Mlf1IP

Mlf1IP: Myelodysplasia-myeloid leukemia factor 1-interacting protein (26 - 203)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

myeloid leukemia factor 1

myelodysplasia-myeloid leukemia factor 1

Related Diseases

Diseases Alias
Thyroid Carcinoma

Thyroid Cancer

Malignant Neoplasm Of Thyroid

Thyroid Neoplasm
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor

Neuroendocrine Tumor Of The Small Intestine

Net Of The Small Intestine

Neuroendocrine Neoplasm Of The Small Intestine

Neuroendocrine Tumor Of Small Bowel

Small Intestinal Neuroendocrine Neoplasm
Unilateral Focal Polymicrogyria
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 1

Muscular Dystrophy, Limb-Girdle, Type 1e

Lgmd1d

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1d

LGMDD1

Lgmd1e

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1

Limb-Girdle Muscular Dystrophy Type 1d

Muscular Dystrophy, Limb-Girdle, Type 1d

Muscular Dystrophy, Limb-Girdle, Type 1d, Formerly

Lgmd1d, Formerly

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1e

Muscular Dystrophy Limb-Girdle Type 1d

Muscular Dystrophy Limb-Girdle Type 1e

Dnajb6-Related Limb-Girdle Muscular Dystrophy D1

Dnajb6-Related Lgmd D1

Lgmd Type 1d

Limb-Girdle Muscular Dystrophy 1e

Limb-Girdle Muscular Dystrophy-1d, Autosomal Dominant

Dystrophy, Muscular, Limb-Girdle, Autosomal Dominant, Type 1

Dystrophy, Muscular, Limb-Girdle, Type 1e
Small Intestine Benign Neoplasm

Neoplasm Of Small Intestine

Small Intestinal Neoplasm

Neoplasm Of The Small Intestine

Small Bowel Cancer

Small Intestine Cancer

Malignant Neoplasm Of Small Intestine, Unspecified

Malignant Tumour Of Small Bowel

Malignant Tumour Of Small Intestine

Primary Malignant Neoplasm Of Meckel Diverticulum
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08487 MLF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MLF1 RGD RGD:1306854
Mus musculus MLF1 MGD MGI:1341819