MLF2 - myeloid leukemia factor 2 Gene

Homo sapiens

Also known as NTN4

Gene ID: 8079 | Gene type: protein coding

About MLF2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,747,996-6,753,141 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 67.7), prostate (RPKM 51.7) and 25 other tissues.

Summary

Predicted to be involved in regulation of transcription, DNA-templated. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MLF2 Products(3)

mRNA	Protein	Name
NM_001382225.1	NP_001369154.1	myeloid leukemia factor 2
NM_001382226.1	NP_001369155.1	myeloid leukemia factor 2
NM_005439.3	NP_005430.1	myeloid leukemia factor 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23414517	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLF2 Protein Structure

Mlf1IP

0
100
200
248 a.a.

Protein Preferred Names

Protein Names

myeloid leukemia factor 2

myelodysplasia-myeloid leukemia factor 2

MLF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MLF2	Q15773	DNAJB6	Homo sapiens	O75190	Y2H Fragment Pooling	23414517
Intra	MLF2	Q15773	DNAJB6	Homo sapiens	O75190	Anti Tag CoIP	25036637
Intra	MLF2	Q15773	BAG2	Homo sapiens	O95816	Lumier	25036637
Intra	MLF2	Q15773	BAG2	Homo sapiens	O95816	Anti Tag CoIP	25036637
Intra	MLF2	Q15773	BAG2	Homo sapiens	O95816	Anti Bait CoIP	17353931
Intra	MLF2	Q15773	STUB1	Homo sapiens	Q9UNE7	Lumier	25036637
Intra	MLF2	Q15773	RAF1	Homo sapiens	P04049	Lumier	25036637
Intra	MLF2	Q15773	MLF1	Homo sapiens	P58340	Lumier	25036637
Intra	MLF2	Q15773	HSPB8	Homo sapiens	Q9UJY1	Y2H Fragment Pooling	23414517
Intra	MLF2	Q15773	BAG3	Homo sapiens	O95817	Anti Tag CoIP	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Fatal Infantile Hypertonic Myofibrillar Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08488	MLF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MLF2	RGD	RGD:1306294
Mus musculus	MLF2	MGD	MGI:1353554

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