MLN - motilin Gene

Homo sapiens

Gene ID: 4295 | Gene type: protein coding

About MLN

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,794,673-33,804,003 (from NCBI)

This gene has 3 transcripts (splice variants) and 92 orthologues. Restricted expression toward duodenum (RPKM 82.5).

Summary

This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]

MLN Products(3)

mRNA	Protein	Name
NM_001040109.2	NP_001035198.1	promotilin isoform 2 preproprotein
NM_001184698.2	NP_001171627.1	promotilin isoform 3 preproprotein
NM_002418.3	NP_002409.1	promotilin isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables motilin receptor binding	IPI IPI: Inferred from physical interaction	10381885	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLN Protein Structure

Motilin_ghrelin

Motilin_assoc

0
100
115 a.a.

Protein Preferred Names

Protein Names

promotilin

prepromotilin

MLN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MLN	P12872	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	MLN	P12872	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	MLN	P12872	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	MLN	P12872	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MLN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70285	Promotilin/MLN Protein, Human (HEK293, His)	P12872-1 (F26-K115)	≥95%

Related Diseases

Diseases

Alias

Gastroparesis

Gastroparesis Syndrome	Delayed Gastric Emptying
Gastric Atonia	Gastroparalysis

Duodenogastric Reflux

Functional Gastric Disease

Pylorospasm

Dumping Syndrome

Jejunal Syndrome	Dumping
Dumping Syndrome	Postgastrectomy Syndromes
Postgastric Surgery Syndrome	Postgastrectomy Syndrome
Post Cibal Syndrome	Postgastrectomy Dumping Syndrome

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Neurogenic Bowel

Pyloric Stenosis

Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Constipation

Zollinger-Ellison Syndrome

Gastrinoma	Pancreatic Ulcerogenic Tumor Syndrome
Z E Syndrome	Zes
Ze - [Zollinger-Ellison] Syndrome

Hypertrophic Pyloric Stenosis

Congenital Hypertrophic Pyloric Stenosis	Pyloric Stenosis, Hypertrophic
Congenital Or Infantile Stricture Of Pylorus	Achalasia Of The Pylorus
Congenital Hypertrophy Of The Pylorus	Infantile Hypertrophy Of The Pylorus
Infantile Constriction Of The Pylorus	Congenital Stenosis Of The Pylorus
Congenital Constriction Of The Pylorus	Congenital Stricture Of The Pylorus
Infantile Hypertrophic Pyloric Stenosis	Infantile Stenosis Of The Pylorus
Infantile Stricture Of The Pylorus	Congenital Or Infantile Constriction Of Pylorus
Infantile Pyloric Obstruction	Infantile Pyloric Hypertrophy
Pylorus Achalasia	Pyloric Constriction
Infantile Pyloric Stricture	Infantile Pyloric Stenosis
Congenital Spasm Of Pylorus	Congenital Pylorospasm
Congenital Pyloric Stricture	Congenital Pyloric Spasm
Congenital Or Infantile Spasm Of Pylorus	Congenital Or Infantile Obstruction Of Pylorus
Congenital Pyloric Stenosis

Functional Colonic Disease

Colonic Diseases, Functional

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Gallbladder Disease

Gallbladder Diseases	Gall Bladder
Gall Bladder Diseases	Abnormal Gallbladder Function

Space Motion Sickness

Acute Porphyria

Porphyrias, Hepatic	Hepatic Porphyria
Porphyria Hepatic	Acute Intermittent Porphyria

Duodenal Ulcer

Stress Ulcer	Curling Ulcer
Stress Ulcer Of Stomach	Curling'S Ulcers
Duodenal Ulcer Disease	Duodenal Ulcers
Duodenal Peptic Ulcer

Postgastrectomy Syndrome

Postgastrectomy Syndromes

Postgastric Surgery Syndrome

Rumination Disorder

Rumination Syndrome	Psychogenic Rumination
Rumination Disorders

Paralytic Ileus

Adynamic Ileus	Paralytic Ileus Of Bowel
Ileus Nos	Paralysis Of Bowel
Paralysis Of Intestine	Adynamic Intestinal Obstruction
Paralytic Intestinal Ileus

Colonic Pseudo-Obstruction

Primary Chronic Pseudo-Obstruction Of Colon

Functional Diarrhea

Functional Diarrhoea

Gastrointestinal System Disease

Gastrointestinal Disease	Gastrointestinal Diseases
Alimentary System Disease	Digestive System Disorder
Gastroenteropathy	Gastrointestinal Disorder
Git Disease	Digestive System Diseases
Gastrointestinal Disorders	Digestive System Disease
Digestive System Disorders

Pneumatosis Cystoides Intestinalis

Postcholecystectomy Syndrome

Post Cholecystectomy Syndrome

Gastroenteritis

Cholera Morbus	Infectious Colitis, Enteritis And Gastroenteritis
Enteritis Due To Astrovirus	Rotaviral Gastroenteritis
Viral Gastroenteritis Due To Rotavirus

Esophagitis

Acute Esophagitis

Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Blind Loop Syndrome

Bacterial Overgrowth Syndrome

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Volvulus Of Midgut

Volvulus	Intestinal Volvulus
Intestinal Malrotation, Familial	Familial Intestinal Malrotation
Twist Of Intestine, Bowel, Or Colon

Peptic Esophagitis

Reflux Esophagitis	Peptic Reflux Disease
Reflux Oesophagitis	Esophagitis, Peptic
Gastro-Esophageal Reflux Disease With Esophagitis

Hernia, Hiatus

Hiatal Hernia	Hiatus Hernia
Diaphragmatic - Hiatus -Hernia	Hernia, Hiatal

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction	Chronic Intestinal Pseudo-Obstruction
Cipo	Neuronal Intestinal Dysplasia
Hollow Visceral Myopathy	Familial Visceral Neuropathy
Paralytic Ileus	Intestinal Pseudoobstruction
Chronic Idiopathic Intestinal Pseudo-Obstruction	Ciip
Congenital Short Bowel Syndrome	Enteric Neuropathy
Familial Visceral Myopathy	Ipo
Pseudo-Obstruction Of Intestine	Pseudointestinal Obstruction Syndrome
Pseudoobstructive Syndrome	Congenital Idiopathic Intestinal Pseudoobstruction
Visceral Myopathy, Familial

Capillary Malformations, Congenital

Familial Multiple Nevi Flammei	Nevi Flammei, Familial Multiple
CMC	Port-Wine Stain
Capillary Malformations	Cmal
Familial Multiple Port-Wine Stains	Capillary Malformation
Capillary Malformations, Congenital, 1, Somatic, Mosaic	Congenital Capillary Malformations
Port-Wine Stain Familial Multiple	Hereditary Capillary Malformations
Capillary Malformations, Hereditary	Capillary Malformations, Congenital, Type 1, Somatic, Mosaic
Strawberry Nevus Of Skin	Naevus Flammeus

Diabetes Mellitus

Diabetes

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10453	Ixazomib		99.85%	Yes
HY-10452	Ixazomib citrate		99.87%	Yes
HY-15246	Tovorafenib	Inhibitor	99.89%	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-70062	Pevonedistat	Inhibitor	99.98%	Phase 3
HY-10971	Alisertib		99.84%	Phase 3
HY-10484	Pevonedistat hydrochloride	Inhibitor	99.19%	Phase 3
HY-10971A	Alisertib sodium		/	Phase 3
HY-13328	Sapanisertib		99.66%	Phase 2
HY-19414	MLN-4760	Inhibitor	99.93%	Phase 2
HY-12285	Serabelisib	Inhibitor	99.44%	Phase 2
HY-10202	Tandutinib		99.48%	Phase 2
HY-10202A	Tandutinib hydrochloride		99.78%	Phase 2
HY-100487	TAK-243		98.38%	Phase 1
HY-10180	MLN8054	Inhibitor	99.54%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99781	Plozalizumab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111373	RapaLink-1		99.27%	Unkown
HY-15473	MLN120B	Inhibitor	99.76%	Unkown
HY-15155	MLN0905	Inhibitor	99.94%	Unkown
HY-123763	MLN3126	Antagonist	98.64%	Unkown
HY-19414A	(R)-MLN-4760	Inhibitor	99.51%	Unkown
HY-N6746	Citrinin		99.72%	Unkown
HY-15473A	MLN120B dihydrochloride	Inhibitor	99.73%	Unkown
HY-10180A	MLN8054 sodium	Inhibitor	/	Unkown
HY-123143	XR11576	Inhibitor	/	Unkown
HY-156401	BRD9 Degrader-1	Inhibitor	/	Unkown
HY-P6008	Myoregulin		/	Unkown
HY-P6008A	Myoregulin TFA		/	Unkown
HY-RS08498	MLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-10202B	Tandutinib sulfate		/	Unkown
HY-W748328	Ixazomib-13C2,15N		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MLN	VGNC	VGNC:74884
Rattus norvegicus	MLN	RGD	RGD:1642907
Felis catus	MLN	VGNC	VGNC:97180
Canis familiaris	MLN	VGNC	VGNC:54970
Bos taurus	MLN	VGNC	VGNC:31505
Macaca fascicularis	MLN	NCBI	NCBI:102146298
Mus musculus	MLN	NCBI
Others	MLN	NCBI