2. Gene
  3. MPG - N-methylpurine DNA glycosylase Gene

MPG - N-methylpurine DNA glycosylase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AAG; MDG; ADPG; APNG; Mid1; anpg; PIG11; PIG16; CRA36.1

Gene ID: 4350 | Gene type: protein coding

About MPG

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:77,007-85,846 (from NCBI)

This gene has 5 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in prostate (RPKM 19.8), spleen (RPKM 17.9) and 25 other tissues.

Summary

Predicted to enable alkylbase DNA N-glycosylase activity. Predicted to be involved in base-excision repair. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MPG Products(3)

mRNA Protein Name
NM_001015052.3 NP_001015052.1 DNA-3-methyladenine glycosylase isoform b
NM_001015054.3 NP_001015054.1 DNA-3-methyladenine glycosylase isoform c
NM_002434.4 NP_002425.2 DNA-3-methyladenine glycosylase isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18482256 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPG Protein Structure

Pur_DNA_glyco

Pur_DNA_glyco: Methylpurine-DNA glycosylase (MPG) (89 - 283)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

DNA-3-methyladenine glycosylase

3' end of the Mid1 gene, localized 68 kb upstream the humanzeta globin gene on 16p

MPG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MPG P29372 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
25416956
Intra
MPG P29372 HSD17B14 Homo sapiens Q9BPX1
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Geotrichosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0084 Dienogest Agonist 99.90% Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-139364 mPGES1-IN-4 Inhibitor / Phase 4
HY-147416 Vipoglanstat Inhibitor 99.74% Phase 2
HY-139589 Zaloglanstat Inhibitor 98.50% Phase 1
Pre-clinical Phase
Bioactive Molecules (32)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-118119 CAY10526 Inhibitor 99.40% Unkown
HY-Y0958 Methoxyamine hydrochloride ≥98.0% Unkown
HY-13283 MF63 Inhibitor 99.55% Unkown
HY-108259 HQL-79 Inhibitor 99.89% Unkown
HY-100800 TACA Agonist 99.33% Unkown
HY-149202 UT-11 Inhibitor 99.62% Unkown
HY-125415 PF-4693627 Inhibitor 99.63% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.04% Unkown
HY-162387 UK4b Inhibitor 96.17% Unkown
HY-111140 YS121 Inhibitor 99.74% Unkown
HY-118282 mPGES1-IN-7 Inhibitor 99.78% Unkown
HY-125975 1-Naphthyl 3,5-dinitrobenzoate Inhibitor 99.49% Unkown
HY-100864 mPGES1-IN-3 Inhibitor / Unkown
HY-117008 CAY10589 Inhibitor / Unkown
HY-126898 5-LO/mPGES1-IN-1 Inhibitor / Unkown
HY-139365 mPGES1-IN-5 Inhibitor / Unkown
HY-144237 BRP-201 / Unkown
HY-144238 mPGES1-IN-6 / Unkown
HY-156612 Friluglanstat Inhibitor / Unkown
HY-162166 COX-2/15-LOX/mPGES1-IN-1 Inhibitor / Unkown
HY-163736 mPGES-1/5-LOX-IN-1 Inhibitor / Unkown
HY-169430 AGU654 Inhibitor / Unkown
HY-19622 PF-9184 Inhibitor 98.10% Unkown
HY-B0084S4 Dienogest-13C,15N,d4 Agonist / Unkown
HY-N9814 Shanciol B Inhibitor / Unkown
HY-P1566 MPG, HIV related / Unkown
HY-RS08611 MPG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-118184 AF3485 Inhibitor / Unkown
HY-122064 FR20 Inhibitor / Unkown
HY-13475 mPGES1-IN-8 Inhibitor / Unkown
HY-164358 α-Gracinoic acid Inhibitor / Unkown
HY-169858 Prostaglandin E2 Inhibitor 3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MPG VGNC VGNC:43334
Macaca mulatta MPG VGNC VGNC:74915
Bos taurus MPG VGNC VGNC:58391
Rattus norvegicus MPG RGD RGD:3106
Mus musculus MPG MGD MGI:97073
Felis catus MPG VGNC VGNC:68306
Others MPG NCBI