2. Gene
  3. H3-5 - H3.5 histone Gene

H3-5 - H3.5 histone Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as H3.5; H3.3C; H3F3C

Gene ID: 440093 | Gene type: protein coding

About H3-5

Cytogenetic location: 12p11.21 Genomic coordinates (GRCh38): 12:31,791,185-31,792,298 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues and 20 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]

H3-5 Products(1)

mRNA Protein Name
NM_001013699.3 NP_001013721.2 histone H3.3C
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nucleosomal DNA binding IDA
IDA: Inferred from direct assay
21274551 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
21274551 GOA
Cellular Component GO Annotation Evidence Reference Source
located in euchromatin IDA
IDA: Inferred from direct assay
21274551 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3-5 Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (57 - 131)

  • 0
  • 100
  • 135 a.a.
Protein Preferred Names Protein Names

histone H3.3C

H3 histone family member 3C

H3-5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra H3-5 Q6NXT2 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 GTF3C3 Homo sapiens Q9Y5Q9
Validated Y2H
32814053
Intra H3-5 Q6NXT2 GTF3C3 Homo sapiens Q9Y5Q9
Y2H Array
32814053
Intra H3-5 Q6NXT2 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra H3-5 Q6NXT2 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra H3-5 Q6NXT2 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
Intra H3-5 Q6NXT2 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
Intra H3-5 Q6NXT2 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 DNAJB6 Homo sapiens O75190-2
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 DNAJB6 Homo sapiens O75190-2
Validated Y2H
32814053
Intra H3-5 Q6NXT2 DNAJB6 Homo sapiens O75190-2
Y2H Array
32814053
Intra H3-5 Q6NXT2 COL26A1 Homo sapiens Q96A83-2
Validated Y2H
32814053
Intra H3-5 Q6NXT2 COL26A1 Homo sapiens Q96A83-2
Y2H Array
32814053
Intra H3-5 Q6NXT2 COL26A1 Homo sapiens Q96A83-2
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra H3-5 Q6NXT2 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra H3-5 Q6NXT2 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 DNAJC9 Homo sapiens Q8WXX5
Y2H Prey Pooling
32296183
Intra H3-5 Q6NXT2 DNAJC9 Homo sapiens Q8WXX5
Y2H Array
32296183
Intra H3-5 Q6NXT2 DNAJC9 Homo sapiens Q8WXX5
Validated Y2H
32296183
Intra H3-5 Q6NXT2 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra H3-5 Q6NXT2 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra H3-5 Q6NXT2 RAN Homo sapiens P62826
Validated Y2H
32814053
Intra H3-5 Q6NXT2 RAN Homo sapiens P62826
Y2H Array
32814053
Intra H3-5 Q6NXT2 RAN Homo sapiens P62826
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 FBLIM1 Homo sapiens Q8WUP2
Y2H Array
32296183
Intra H3-5 Q6NXT2 FBLIM1 Homo sapiens Q8WUP2
Y2H Prey Pooling
32296183
Intra H3-5 Q6NXT2 FBLIM1 Homo sapiens Q8WUP2
Validated Y2H
32296183
Intra H3-5 Q6NXT2 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra H3-5 Q6NXT2 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra H3-5 Q6NXT2 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 LSAMP Homo sapiens Q13449
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 LSAMP Homo sapiens Q13449
Validated Y2H
32814053
Intra H3-5 Q6NXT2 LSAMP Homo sapiens Q13449
Y2H Array
32814053
Intra H3-5 Q6NXT2 ICAM5 Homo sapiens Q9UMF0
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 ICAM5 Homo sapiens Q9UMF0
Validated Y2H
32814053
Intra H3-5 Q6NXT2 ICAM5 Homo sapiens Q9UMF0
Y2H Array
32814053
Intra H3-5 Q6NXT2 CCK Homo sapiens P06307
Validated Y2H
32814053
Intra H3-5 Q6NXT2 CCK Homo sapiens P06307
Y2H Array
32814053
Intra H3-5 Q6NXT2 CCK Homo sapiens P06307
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 NASP Homo sapiens P49321-2
Y2H Prey Pooling
32296183
Intra H3-5 Q6NXT2 NASP Homo sapiens P49321-2
Y2H Array
32296183
Intra H3-5 Q6NXT2 NASP Homo sapiens P49321-2
Validated Y2H
25416956
Intra H3-5 Q6NXT2 HMOX2 Homo sapiens P30519
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 HMOX2 Homo sapiens P30519
Validated Y2H
32814053
Intra H3-5 Q6NXT2 HMOX2 Homo sapiens P30519
Y2H Array
32814053
Intra H3-5 Q6NXT2 CASP6 Homo sapiens P55212
Validated Y2H
32814053
Intra H3-5 Q6NXT2 CASP6 Homo sapiens P55212
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 CASP6 Homo sapiens P55212
Y2H Array
32814053
Intra H3-5 Q6NXT2 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra H3-5 Q6NXT2 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra H3-5 Q6NXT2 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 GRN Homo sapiens P28799
Y2H Array
32814053
Intra H3-5 Q6NXT2 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra H3-5 Q6NXT2 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
Intra H3-5 Q6NXT2 DR1 Homo sapiens Q01658
Validated Y2H
32814053
Intra H3-5 Q6NXT2 DR1 Homo sapiens Q01658
Y2H Array
32814053
Intra H3-5 Q6NXT2 DAXX Homo sapiens Q9UER7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05964 H3-5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W377455 2',5-Difluoro-2'-deoxy-1-arabinosyluracil / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus H3-5 MGD MGI:3651714