MT3 - metallothionein 3 Gene

Homo sapiens

Also known as GIF; GIFB; GRIF; ZnMT3

Gene ID: 4504 | Gene type: protein coding

About MT3

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,589,528-56,591,085 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues and 11 paralogues. Biased expression in brain (RPKM 149.3) and adrenal (RPKM 10.1).

Summary

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific expression, and contains a threonine insert near its N-terminus and a glutamate-rich hexapeptide insert near its C-terminus relative to the proteins encoded by Other gene family members. It plays an important role in zinc and copper homeostasis, and is induced under hypoxic conditions. The encoded protein is a growth inhibitory factor, and reduced levels of the protein are observed in the brains of individuals with some metal-linked neurodegenerative disorders such as Alzheimer's disease. [provided by RefSeq, Sep 2017]

MT3 Products(1)

mRNA	Protein	Name
NM_005954.4	NP_005945.1	metallothionein-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadmium ion binding	IDA IDA: Inferred from direct assay	16601975	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	21320589	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20646067	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	18295594	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17712581	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	18295594	GOA
involved in cellular detoxification	IDA IDA: Inferred from direct assay	18554677	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	18206644	GOA
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	20039155	GOA
involved in cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	18554677	GOA
involved in negative regulation of axon extension	IDA IDA: Inferred from direct assay	16601975	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	16601975	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16945328	GOA
involved in negative regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	21320589	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18295594	GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	18295594	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18295594	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	12383939	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12763630	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10355541	GOA
located in inclusion body	IDA IDA: Inferred from direct assay	20039155	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20039155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT3 Protein Structure

Metallothio

0
68 a.a.

Protein Preferred Names

Protein Names

metallothionein-3

growth inhibitory factor

MT3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MT3	P25713	TTR	Homo sapiens	P02766	Anti Tag CoIP	20646067
Intra	MT3	P25713	TTR	Homo sapiens	P02766	Saturation Binding	20646067
Intra	MT3	P25713	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Milker'S Nodule

Poxviridae Infections	Milker Nodule
Milkers' Node	Paravaccinia
Pseudocowpox	Milker'S Nodes

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128206	I3MT-3	Inhibitor	99.98%	Unkown
HY-P5846	Muscarinic toxin 3	Antagonist	/	Unkown
HY-RS08744	MT3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MT3	RGD	RGD:621252
Mus musculus	MT3	MGD	MGI:97173
Bos taurus	MT3	VGNC	VGNC:52208
Others	MT3	NCBI

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