GADD45B - growth arrest and DNA damage inducible beta Gene

Homo sapiens

Also known as MYD118; GADD45BETA

Gene ID: 4616 | Gene type: protein coding

About GADD45B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,476,127-2,478,257 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 2 paralogues. Broad expression in liver (RPKM 112.2), bone marrow (RPKM 99.7) and 23 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and Apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GADD45B Products(1)

mRNA	Protein	Name
NM_015675.4	NP_056490.2	growth arrest and DNA damage-inducible protein GADD45 beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12052864	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	9827804	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9827804	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9827804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GADD45B Protein Structure

Ribosomal_L7Ae

0
100
160 a.a.

Protein Preferred Names

Protein Names

growth arrest and DNA damage-inducible protein GADD45 beta

myeloid differentiation primary response protein MyD118

Recombinant GADD45B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70212	GADD45B Protein, Human (His)	O75293 (M1-R160)	≥95%

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05230	GADD45B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GADD45B	VGNC	VGNC:72864
Canis familiaris	GADD45B	VGNC	VGNC:41070
Bos taurus	GADD45B	VGNC	VGNC:29207
Rattus norvegicus	GADD45B	RGD	RGD:1309080
Felis catus	GADD45B	VGNC	VGNC:62432
Mus musculus	GADD45B	MGD	MGI:107776
Others	GADD45B	NCBI

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