2. Gene
  3. MAP2K7 - mitogen-activated protein kinase kinase 7 Gene

MAP2K7 - mitogen-activated protein kinase kinase 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4

Gene ID: 5609 | Gene type: protein coding

About MAP2K7

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,903,877-7,914,478 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 8.9) and 25 other tissues.

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP2K7 Products(3)

mRNA Protein Name
NM_001297555.2 NP_001284484.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001297556.2 NP_001284485.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 2
NM_145185.4 NP_660186.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 3

MAP2K7 Protein Structure

Pkinase

Pkinase: Protein kinase domain (122 - 380)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 7

JNK-activating kinase 2

Related Diseases

Diseases Alias
Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25

CMH25

Cardiomyopathy, Hypertrophic, 25

Cardiomyopathy Familial Hypertrophic 25

Cardiomyopathy, Familial Hypertrophic 25

Cardiomyopathy, Hypertrophic, Type 25
Fallopian Tube Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Fallopian Tube
Mucocele Of Appendix

Appendicele Mucocele

Appendicular Mucocele

Appendiceal Mucocele
Fallopian Tube Endometriosis

Endometriosis Of Fallopian Tube

Adenomyosis Of Fallopian Tube
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08045 MAP2K7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAP2K7 RGD RGD:1560043
Canis familiaris MAP2K7 VGNC VGNC:42965
Macaca mulatta MAP2K7 VGNC VGNC:81457
Bos taurus MAP2K7 VGNC VGNC:54447
Mus musculus MAP2K7 MGD MGI:1346871
Felis catus MAP2K7 VGNC VGNC:80622
Others MAP2K7 NCBI