MAP2K7 - mitogen-activated protein kinase kinase 7 Gene

Homo sapiens

Also known as MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4

Gene ID: 5609 | Gene type: protein coding

About MAP2K7

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,903,877-7,914,478 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 8.9) and 25 other tissues.

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MAP2K7 Products(3)

mRNA	Protein	Name
NM_001297555.2	NP_001284484.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 1
NM_001297556.2	NP_001284485.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 2
NM_145185.4	NP_660186.1	dual specificity mitogen-activated protein kinase kinase 7 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	9535930	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	14615289	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9535930	GOA
enables molecular function activator activity	EXP EXP: Inferred from Experiment	25737554	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15299019	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	14697235	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	28111074	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	28111074	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in response to UV	IDA IDA: Inferred from direct assay	9535930	GOA
involved in response to heat	IDA IDA: Inferred from direct assay	9535930	GOA
involved in response to osmotic stress	IDA IDA: Inferred from direct assay	9535930	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	9535930	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	9535930	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP2K7 Protein Structure

Pkinase

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 7

JNK-activating kinase 2

MAP2K7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP2K7	O14733	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	MAP2K7	O14733	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	MAP2K7	O14733	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MAP2K7	O14733	MAP3K7	Homo sapiens	O43318	PLA	25241761
Intra	MAP2K7	O14733	GADD45B	Homo sapiens	O75293	CD	25314077
Intra	MAP2K7	O14733	GADD45B	Homo sapiens	O75293	Solid Phase Assay	25314077
Intra	MAP2K7	O14733	CFLAR	Homo sapiens	O15519-1	Anti Tag CoIP	17110930
Intra	MAP2K7	O14733	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	20067578

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 25

Hypertrophic Cardiomyopathy 25	CMH25
Cardiomyopathy, Hypertrophic, 25	Cardiomyopathy Familial Hypertrophic 25
Cardiomyopathy, Familial Hypertrophic 25	Cardiomyopathy, Hypertrophic, Type 25

Fallopian Tube Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Fallopian Tube

Mucocele Of Appendix

Appendicele Mucocele	Appendicular Mucocele
Appendiceal Mucocele

Fallopian Tube Endometriosis

Endometriosis Of Fallopian Tube

Adenomyosis Of Fallopian Tube

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08045	MAP2K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-D2415	BODIPY-FL staurosporine		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP2K7	RGD	RGD:1560043
Canis familiaris	MAP2K7	VGNC	VGNC:42965
Macaca mulatta	MAP2K7	VGNC	VGNC:81457
Bos taurus	MAP2K7	VGNC	VGNC:54447
Mus musculus	MAP2K7	MGD	MGI:1346871
Felis catus	MAP2K7	VGNC	VGNC:80622
Others	MAP2K7	NCBI

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