CEACAM6 - CEA cell adhesion molecule 6 Gene

Homo sapiens

Also known as NCA; CEAL; CD66c

Gene ID: 4680 | Gene type: protein coding

About CEACAM6

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,755,530-41,772,211 (from NCBI)

This gene has 2 transcripts (splice variants), 568 orthologues, 24 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 147.4), lung (RPKM 142.2) and 9 other tissues.

Summary

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus Infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

CEACAM6 Products(1)

mRNA	Protein	Name
NM_002483.7	NP_002474.4	carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	26483485	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	26483485	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	2803308	GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IMP IMP: Inferred from mutant phenotype	2803308	GOA
involved in negative regulation of anoikis	IMP IMP: Inferred from mutant phenotype	10910050	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16204051	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	25171863	GOA
involved in positive regulation of endothelial cell-matrix adhesion via fibronectin	IMP IMP: Inferred from mutant phenotype	16204051	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	16204051	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10436421	GOA
located in cell surface	IDA IDA: Inferred from direct assay	2317824	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	25645918	GOA
located in membrane	IDA IDA: Inferred from direct assay	2317824	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM6 Protein Structure

V-set

Ig_3

Ig_2

0
100
200
300
344 a.a.

Protein Preferred Names

Protein Names

carcinoembryonic antigen-related cell adhesion molecule 6

Cluster of Differentiation 66c

CEACAM6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEACAM6	P40199	MSS51	Homo sapiens	Q4VC12	Validated Y2H	32296183
Intra	CEACAM6	P40199	MSS51	Homo sapiens	Q4VC12	Y2H Array	32296183
Intra	CEACAM6	P40199	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
Intra	CEACAM6	P40199	VEZF1	Homo sapiens	Q14119	Validated Y2H	32296183
Intra	CEACAM6	P40199	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	CEACAM6	P40199	ASPG	Homo sapiens	Q86U10	Validated Y2H	32296183
Intra	CEACAM6	P40199	ASPG	Homo sapiens	Q86U10	Y2H Array	32296183
Intra	CEACAM6	P40199	ASPG	Homo sapiens	Q86U10	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	CEACAM6	P40199	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	CEACAM6	P40199	EXOC3L1	Homo sapiens	Q86VI1	Validated Y2H	32296183
Intra	CEACAM6	P40199	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	CEACAM6	P40199	RHOXF2	Homo sapiens	Q9BQY4	Validated Y2H	32296183
Intra	CEACAM6	P40199	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	CIB1	Homo sapiens	Q99828	Validated Y2H	32296183
Intra	CEACAM6	P40199	CIB1	Homo sapiens	Q99828	Y2H Array	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Protein Array	21982860
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Validated Y2H	32296183
Intra	CEACAM6	P40199	HPCAL4	Homo sapiens	Q9UM19	Validated Y2H	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Y2H Array	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	Solution Sedimentation	26483485
Intra	CEACAM6	P40199	CEACAM8	Homo sapiens	P31997	X-Ray Diffraction	26483485
Intra	CEACAM6	P40199	HPCAL4	Homo sapiens	Q9UM19	Y2H Array	32296183
Intra	CEACAM6	P40199	CEACAM6	Homo sapiens	P40199	X-Ray Diffraction	26483485
Intra	CEACAM6	P40199	HPCAL4	Homo sapiens	Q9UM19	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	CARTPT	Homo sapiens	Q16568	Protein Array	21982860
Intra	CEACAM6	P40199	CARTPT	Homo sapiens	Q16568	SPR	21982860
Intra	CEACAM6	P40199	MYOZ1	Homo sapiens	Q9NP98	Validated Y2H	32296183
Intra	CEACAM6	P40199	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183
Intra	CEACAM6	P40199	ZMYND19	Homo sapiens	Q96E35	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	ZMYND19	Homo sapiens	Q96E35	Y2H Array	32296183
Intra	CEACAM6	P40199	PITX1	Homo sapiens	P78337	Validated Y2H	32296183
Intra	CEACAM6	P40199	SHC3	Homo sapiens	Q92529	Validated Y2H	32296183
Intra	CEACAM6	P40199	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	CEACAM6	P40199	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CEACAM6	P40199	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEACAM6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72131	CEACAM6 Protein, Human (His-SUMO)	P40199 (K35-G320)	≥95%
HY-P75671	CEACAM6 Protein, Human (Biotinylated, HEK293, His)	P40199 (K35-G320)	≥95%
HY-P78081	CEACAM6 Protein, Human (Biotinylated, HEK293, His-Avi)	P40199 (K35-G320)	≥95%
HY-P78397	CEACAM6 Protein, Human (HEK293, His-Avi)	P40199 (K35-G320)	≥95%
HY-P700471	CEACAM6 Protein, Human (HEK293, His)	P40199 (K35-G320)	≥95%

CEACAM6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83606	CEACAM6 Antibody (YA3351)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Gastrointestinal Carcinoma

Gastrointestinal Neoplasms

Adenocarcinoma

Adenocarcinomas	Adenoacanthoma Of Unspecified Site
Adenocarcinoid Of Unspecified Site	Adenocarcinoid Tumour Of Unspecified Site
Adenocarcinoma And Carcinoid Combined Of Unspecified Site	Adenocarcinoma Nos

Pancreatic Adenocarcinoma

Adenocarcinoma Of The Pancreas	Adenocarcinoma Of Pancreas
Pancreas Adenocarcinoma	Malignant Exocrine Neoplasm
Primary Pancreatic Adenocarcinoma	Adenocarcinoma Of Islet Cell Of Pancreas
Islet Cell Adenocarcinoma Of Unspecified Site	Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To	Extrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma	Chlc
Chlc, Susceptibility To	Cc
Cholangiocarcinoma Of Biliary Tract	Cholangiocellular Carcinoma
Distal Cholangiocarcinoma	Perihilar Cholangiocarcinoma
Bile Duct Cancer	Cca
Adult Primary Cholangiocellular Carcinoma	Bile Duct Carcinoma

Ovarian Mucinous Adenocarcinoma

Mucinous Carcinoma Of Ovary

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02442	CEACAM6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CEACAM6	RGD	RGD:1642421
Macaca fascicularis	CEACAM6	NCBI
Others	CEACAM6	NCBI

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