ASPG - asparaginase Gene

Homo sapiens

Also known as GPA/WT; LYSOLP; C14orf76; hASNase1

Gene ID: 374569 | Gene type: protein coding

About ASPG

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:104,085,700-104,115,582 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Biased expression in liver (RPKM 7.5), kidney (RPKM 3.8) and 8 other tissues.

Summary

Predicted to enable Acyltransferase activity, transferring groups Other than amino-acyl groups; asparaginase activity; and lysophospholipase activity. Predicted to be involved in asparagine metabolic process and phospholipid metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ASPG Products(2)

mRNA	Protein	Name
NM_001080464.3	NP_001073933.2	60 kDa lysophospholipase isoform 1
NM_001411060.1	NP_001397989.1	60 kDa lysophospholipase isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASPG Protein Structure

Asparaginase

Ank_2

0
100
200
300
400
500
573 a.a.

Protein Preferred Names

Protein Names

60 kDa lysophospholipase

PAF acetylhydrolase

ASPG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ASPG	Q86U10	CIMIP1	Homo sapiens	Q9H1P6	Validated Y2H	32296183
Intra	ASPG	Q86U10	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	ASPG	Q86U10	VPS25	Homo sapiens	Q9BRG1	Validated Y2H	32296183
Intra	ASPG	Q86U10	SHC3	Homo sapiens	Q92529	Validated Y2H	32296183
Intra	ASPG	Q86U10	TEKT3	Homo sapiens	Q9BXF9	Validated Y2H	32296183
Intra	ASPG	Q86U10	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Esophagus Lymphoma

Lymphoma Of Esophagus	Lymphoma Of Oesophagus
Oesophagus Lymphoma	Esophageal Lymphoma

Testicular Leukemia

Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All

Childhood Leukemia

Central Nervous System Leukemia

Leukemia Of The Cns

Mastoiditis

Mastoiditis Nec

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01101	ASPG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ASPG	VGNC	VGNC:26218
Macaca mulatta	ASPG	VGNC	VGNC:70101
Canis familiaris	ASPG	VGNC	VGNC:50441
Felis catus	ASPG	VGNC	VGNC:59975
Rattus norvegicus	ASPG	RGD	RGD:708388
Mus musculus	ASPG	MGD	MGI:2144822

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