2. Gene
  3. NDUFA3 - NADH:ubiquinone oxidoreductase subunit A3 Gene

NDUFA3 - NADH:ubiquinone oxidoreductase subunit A3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B9; CI-B9

Gene ID: 4696 | Gene type: protein coding

About NDUFA3

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,102,855-54,107,568 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 238 orthologues. Ubiquitous expression in kidney (RPKM 30.6), fat (RPKM 26.2) and 25 other tissues.

Summary

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]

NDUFA3 Products(1)

mRNA Protein Name
NM_004542.4 NP_004533.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
27626371 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
12611891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFA3 Protein Structure

NADHdh_A3

NADHdh_A3: NADH dehydrogenase 1 alpha subcomplex subunit 3 (1 - 84)

  • 0
  • 84 a.a.
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa

NDUFA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra NDUFA3 O95167 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra NDUFA3 O95167 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra NDUFA3 O95167 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra NDUFA3 O95167 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra NDUFA3 O95167 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra NDUFA3 O95167 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra NDUFA3 O95167 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 GOLT1A Homo sapiens Q6ZVE7
Validated Y2H
32296183
Intra NDUFA3 O95167 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra NDUFA3 O95167 CRB3 Homo sapiens Q9BUF7-2
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 CRB3 Homo sapiens Q9BUF7-2
Validated Y2H
32296183
Intra NDUFA3 O95167 CRB3 Homo sapiens Q9BUF7-2
Y2H Array
32296183
Intra NDUFA3 O95167 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 MUC1 Homo sapiens P15941-11
Validated Y2H
32296183
Intra NDUFA3 O95167 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra NDUFA3 O95167 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra NDUFA3 O95167 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra NDUFA3 O95167 TMEM101 Homo sapiens Q96IK0
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TMEM101 Homo sapiens Q96IK0
Validated Y2H
32296183
Intra NDUFA3 O95167 TMEM101 Homo sapiens Q96IK0
Y2H Array
32296183
Intra NDUFA3 O95167 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra NDUFA3 O95167 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra NDUFA3 O95167 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TMEM205 Homo sapiens Q6UW68
Validated Y2H
32296183
Intra NDUFA3 O95167 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra NDUFA3 O95167 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra NDUFA3 O95167 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra NDUFA3 O95167 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra NDUFA3 O95167 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra NDUFA3 O95167 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra NDUFA3 O95167 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 LEPROTL1 Homo sapiens O95214
Validated Y2H
32296183
Intra NDUFA3 O95167 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra NDUFA3 O95167 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra NDUFA3 O95167 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra NDUFA3 O95167 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia 5

SCZD5

Schizophrenia Susceptibility Locus, Chromosome 6q-Related

Schizophrenia 5 With Or Without An Affective Disorder
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09128 NDUFA3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NDUFA3 RGD RGD:1588687
Mus musculus NDUFA3 MGD MGI:1913341
Felis catus NDUFA3 VGNC VGNC:81202