LEPROTL1 - leptin receptor overlapping transcript like 1 Gene

Homo sapiens

Also known as Vps55; my047; HSPC112

Gene ID: 23484 | Gene type: protein coding

About LEPROTL1

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,095,408-30,138,348 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 55 phenotypes. Ubiquitous expression in placenta (RPKM 29.1), lymph node (RPKM 17.8) and 24 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]

LEPROTL1 Products(2)

mRNA	Protein	Name
NM_001128208.2	NP_001121680.1	leptin receptor overlapping transcript-like 1 isoform 2
NM_015344.3	NP_056159.2	leptin receptor overlapping transcript-like 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LEPROTL1 Protein Structure

Vps55

0
100
131 a.a.

Protein Preferred Names

Protein Names

leptin receptor overlapping transcript-like 1

endospanin-2

LEPROTL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LEPROTL1	O95214	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	LEPROTL1	O95214	NRM	Homo sapiens	Q8IXM6	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SLC25A46	Homo sapiens	Q96AG3	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	LEPROTL1	O95214	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	LEPROTL1	O95214	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	LEPROTL1	O95214	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	LEPROTL1	O95214	VAPA	Homo sapiens	Q9P0L0	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	LEPROTL1	O95214	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	LEPROTL1	O95214	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	LEPROTL1	O95214	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	LEPROTL1	O95214	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	LEPROTL1	O95214	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	CLEC2D	Homo sapiens	Q9UHP7-3	Validated Y2H	32296183
Intra	LEPROTL1	O95214	CLEC2D	Homo sapiens	Q9UHP7-3	Y2H Array	32296183
Intra	LEPROTL1	O95214	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	LEPROTL1	O95214	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	KCNJ6	Homo sapiens	P48051	Validated Y2H	32296183
Intra	LEPROTL1	O95214	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM42	Homo sapiens	Q69YG0	Validated Y2H	32296183
Intra	LEPROTL1	O95214	PLP1	Homo sapiens	P60201-2	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM50B	Homo sapiens	P56557	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	TMEM50B	Homo sapiens	P56557	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM50B	Homo sapiens	P56557	Y2H Array	32296183
Intra	LEPROTL1	O95214	TGFA	Homo sapiens	P01135-2	Y2H Array	32296183
Intra	LEPROTL1	O95214	TGFA	Homo sapiens	P01135-2	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TGFA	Homo sapiens	P01135-2	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	FMO1	Homo sapiens	Q01740	Validated Y2H	32296183
Intra	LEPROTL1	O95214	FMO1	Homo sapiens	Q01740	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	FMO1	Homo sapiens	Q01740	Y2H Array	32296183
Intra	LEPROTL1	O95214	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	LEPROTL1	O95214	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	LEPROTL1	O95214	PAQR8	Homo sapiens	Q8TEZ7	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM50A	Homo sapiens	O95807	Validated Y2H	32296183
Intra	LEPROTL1	O95214	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	LEPROTL1	O95214	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	LEPROTL1	O95214	SLC30A4	Homo sapiens	O14863	Y2H Array	32296183
Intra	LEPROTL1	O95214	SLC30A4	Homo sapiens	O14863	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	LEPROTL1	O95214	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	LEPROTL1	O95214	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	LEPROTL1	O95214	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	LEPROTL1	O95214	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	LEPROTL1	O95214	CYP4F2	Homo sapiens	P78329	Validated Y2H	32296183
Intra	LEPROTL1	O95214	AGPAT4	Homo sapiens	Q9NRZ5	Validated Y2H	32296183
Intra	LEPROTL1	O95214	MSR1	Homo sapiens	P21757	Y2H Array	31515488
Intra	LEPROTL1	O95214	MSR1	Homo sapiens	P21757	Validated Y2H	32296183
Intra	LEPROTL1	O95214	MSR1	Homo sapiens	P21757	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	MSR1	Homo sapiens	P21757	Y2H Array	32296183
Intra	LEPROTL1	O95214	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	LEPROTL1	O95214	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	LEPROTL1	O95214	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	LEPROTL1	O95214	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	LEPROTL1	O95214	STX12	Homo sapiens	Q86Y82	Validated Y2H	32296183
Intra	LEPROTL1	O95214	STING1	Homo sapiens	Q86WV6	Validated Y2H	32296183
Intra	LEPROTL1	O95214	STING1	Homo sapiens	Q86WV6	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	STING1	Homo sapiens	Q86WV6	Y2H Array	32296183
Intra	LEPROTL1	O95214	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	LEPROTL1	O95214	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	LEPROTL1	O95214	NAT8	Homo sapiens	Q9UHE5	Validated Y2H	32296183
Intra	LEPROTL1	O95214	RBFA	Homo sapiens	Q8N0V3	Validated Y2H	32296183
Intra	LEPROTL1	O95214	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	LEPROTL1	O95214	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	LEPROTL1	O95214	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	LEPROTL1	O95214	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	MFSD14B	Homo sapiens	Q5SR56	Validated Y2H	32296183
Intra	LEPROTL1	O95214	CD300C	Homo sapiens	Q08708	Validated Y2H	32296183
Intra	LEPROTL1	O95214	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	LRRC4C	Homo sapiens	Q9HCJ2	Validated Y2H	32296183
Intra	LEPROTL1	O95214	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Array	32296183
Intra	LEPROTL1	O95214	SLC7A1	Homo sapiens	P30825	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	LEPROTL1	O95214	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	LEPROTL1	O95214	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	LEPROTL1	O95214	JPH1	Homo sapiens	Q9HDC5	Validated Y2H	32296183
Intra	LEPROTL1	O95214	JPH1	Homo sapiens	Q9HDC5	Y2H Array	32296183
Intra	LEPROTL1	O95214	JPH1	Homo sapiens	Q9HDC5	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	EDA	Homo sapiens	Q92838	Y2H Array	31515488
Intra	LEPROTL1	O95214	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	EDA	Homo sapiens	Q92838	Validated Y2H	32296183
Intra	LEPROTL1	O95214	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	LEPROTL1	O95214	LMBR1	Homo sapiens	Q8WVP7	Validated Y2H	32296183
Intra	LEPROTL1	O95214	LMBR1	Homo sapiens	Q8WVP7	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	LMBR1	Homo sapiens	Q8WVP7	Y2H Array	32296183
Intra	LEPROTL1	O95214	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	LEPROTL1	O95214	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	LEPROTL1	O95214	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	LEPROTL1	O95214	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	LEPROTL1	O95214	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	LEPROTL1	O95214	ORMDL3	Homo sapiens	Q8N138	Validated Y2H	32296183
Intra	LEPROTL1	O95214	TMEM11	Homo sapiens	P17152	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SYNDIG1	Homo sapiens	Q9H7V2	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	SYNDIG1	Homo sapiens	Q9H7V2	Y2H Array	32296183
Intra	LEPROTL1	O95214	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	LEPROTL1	O95214	CLDN7	Homo sapiens	O95471	Validated Y2H	32296183
Intra	LEPROTL1	O95214	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	LEPROTL1	O95214	TMEM19	Homo sapiens	Q96HH6	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	LEPROTL1	O95214	MALL	Homo sapiens	Q13021	Validated Y2H	32296183
Intra	LEPROTL1	O95214	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	GJA5	Homo sapiens	P36382	Validated Y2H	32296183
Intra	LEPROTL1	O95214	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	LEPROTL1	O95214	KLRG1	Homo sapiens	Q96E93	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	KLRG1	Homo sapiens	Q96E93	Validated Y2H	32296183
Intra	LEPROTL1	O95214	KLRG1	Homo sapiens	Q96E93	Y2H Array	32296183
Intra	LEPROTL1	O95214	YIPF2	Homo sapiens	Q9BWQ6	Validated Y2H	32296183
Intra	LEPROTL1	O95214	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	LEPROTL1	O95214	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	LEPROTL1	O95214	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	LEPROTL1	O95214	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	LEPROTL1	O95214	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	LEPROTL1	O95214	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	LEPROTL1	O95214	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	LEPROTL1	O95214	PEX16	Homo sapiens	Q9Y5Y5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rectal Benign Neoplasm

Neoplasm Of Rectum	Rectal Tumor
Rectum Neoplasm	Neoplasm Of The Rectum
Rectal Neoplasms	Primary Rectal Cancer
Rectal Ampulla Cancer	Cancer Of The Rectum
Carcinoma Of Rectum	Primary Malignant Neoplasm Of Rectum
Rectal Cancer	Rectal Carcinoma

Esophagus Adenocarcinoma

Esophageal Adenocarcinoma	Oesophageal Adenocarcinoma
Adenocarcinoma Of Esophagus	Adenocarcinoma Of The Esophagus

Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07596	LEPROTL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LEPROTL1	VGNC	VGNC:30845
Rattus norvegicus	LEPROTL1	RGD	RGD:1307168
Macaca mulatta	LEPROTL1	VGNC	VGNC:74252
Felis catus	LEPROTL1	VGNC	VGNC:78521
Mus musculus	LEPROTL1	MGD	MGI:1915442
Canis familiaris	LEPROTL1	VGNC	VGNC:42640

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