NFKBIE - NFKB inhibitor epsilon Gene

Homo sapiens

Also known as IKBE

Gene ID: 4794 | Gene type: protein coding

About NFKBIE

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,258,166-44,265,551 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues, 16 paralogues and is associated with 54 phenotypes. Broad expression in bone marrow (RPKM 9.4), spleen (RPKM 9.3) and 25 other tissues.

Summary

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

NFKBIE Products(1)

mRNA	Protein	Name
NM_004556.3	NP_004547.3	NF-kappa-B inhibitor epsilon

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBIE Protein Structure

Ank_2

0
100
200
300
400
500 a.a.

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor epsilon

I-kappa-B-epsilon

NFKBIE Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFKBIE	O00221	REL	Homo sapiens	Q04864	TAP	14743216
Intra	NFKBIE	O00221	ANKHD1	Homo sapiens	Q8IWZ3	TAP	14743216
Intra	NFKBIE	O00221	ANKHD1	Homo sapiens	Q8IWZ3	Y2H Array	21988832
Intra	NFKBIE	O00221	PPP6R2	Homo sapiens	O75170	Anti Tag CoIP	16769727
Intra	NFKBIE	O00221	PPP6R2	Homo sapiens	O75170	TAP	14743216
Intra	NFKBIE	O00221	PPP6R1	Homo sapiens	Q9UPN7	TAP	14743216

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09263	NFKBIE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFKBIE	MGD	MGI:1194908
Bos taurus	NFKBIE	VGNC	VGNC:32048
Felis catus	NFKBIE	VGNC	VGNC:68485
Rattus norvegicus	NFKBIE	RGD	RGD:735070
Macaca mulatta	NFKBIE	VGNC	VGNC:75342
Others	NFKBIE	NCBI

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