1. Gene
  2. NQO2 - N-ribosyldihydronicotinamide:quinone reductase 2 Gene

NQO2 - N-ribosyldihydronicotinamide:quinone reductase 2 Gene

Homo sapiens

Also known as QR2; DHQV; DIA6; NMOR2

Gene ID: 4835 | Gene type: protein coding

About NQO2

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:2,999,894-3,019,755 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in kidney (RPKM 43.3), fat (RPKM 18.6) and 24 other tissues.

Summary

This gene encodes a member of the thioredoxin family of Enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

NQO2 Products(4)

mRNA Protein Name
NM_000904.6 NP_000895.2 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
NM_001290221.2 NP_001277150.1 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
NM_001290222.2 NP_001277151.1 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2
NM_001318940.2 NP_001305869.1 ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables FAD binding IDA
IDA: Inferred from direct assay
18254726 GOA
enables chloride ion binding IDA
IDA: Inferred from direct assay
18254726 GOA
enables dihydronicotinamide riboside quinone reductase activity IDA
IDA: Inferred from direct assay
18254726 GOA
enables electron transfer activity IDA
IDA: Inferred from direct assay
10945627 GOA
enables melatonin binding IDA
IDA: Inferred from direct assay
18254726 GOA
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
10945627 GOA
enables oxidoreductase activity, acting on other nitrogenous compounds as donors IDA
IDA: Inferred from direct assay
10945627 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
18254726 GOA
enables resveratrol binding IDA
IDA: Inferred from direct assay
18254726 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
18254726 GOA
Biological Process GO Annotation Evidence Reference Source
involved in quinone catabolic process IDA
IDA: Inferred from direct assay
18254726 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
10945627 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NQO2 Protein Structure

Flavodoxin_2

Flavodoxin_2: Flavodoxin-like fold (4 - 212)

  • 0
  • 100
  • 200
  • 231 a.a.
Protein Preferred Names Protein Names

ribosyldihydronicotinamide dehydrogenase [quinone]

NAD(P)H dehydrogenase, quinone 2

NQO2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NQO2 P16083 LRRC7 Homo sapiens A1L1C6 25416956
Intra
NQO2 P16083 LRRC7 Homo sapiens A1L1C6 25416956
Intra
NQO2 P16083 GORASP2 Homo sapiens Q9H8Y8 16189514
Intra
NQO2 P16083 GORASP2 Homo sapiens Q9H8Y8 32296183
Intra
NQO2 P16083 GORASP2 Homo sapiens Q9H8Y8 31515488
Intra
NQO2 P16083 DDIT4L Homo sapiens Q96D03 32296183
Intra
NQO2 P16083 DDIT4L Homo sapiens Q96D03 32296183
Intra
NQO2 P16083 DDIT4L Homo sapiens Q96D03 32296183
Intra
NQO2 P16083 SPG21 Homo sapiens Q9NZD8 32296183
Intra
NQO2 P16083 SPG21 Homo sapiens Q9NZD8 32296183
Intra
NQO2 P16083 SPG21 Homo sapiens Q9NZD8 32296183
Intra
NQO2 P16083 EFHC1 Homo sapiens Q5JVL4 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

NQO2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82542 NQO2 Antibody (YA2287) WB, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Familial Adenomatous Polyposis 3

FAP3

Nthl1-Related Attenuated Familial Adenomatous Polyposis

Nthl1-Related Afap

Nthl1-Related Attenuated Fap

Granulocytopenia

Agranulocytosis

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease

PARK2

Pdj

Autosomal Recessive Juvenile Parkinson Disease 2

Epdf

Parkinson Disease, Juvenile, Type 2

Parkinson'S Disease 2

Autosomal Recessive Juvenile Parkinson Disease

Early-Onset Parkinson Disease

Parkinson Disease 2

Parkinson Disease, Juvenile, Autosomal Recessive

Parkinsonism, Early-Onset, With Diurnal Fluctuation

Autosomal Recessive Juvenile Parkinson'S Disease 2

Jp

Juvenile Parkinsonism

Parkinson Disease Autosomal Recessive, Early Onset

Parkinsonism, Early Onset, With Diurnal Fluctuation

Yopd

Autosomal Recessive Early-Onset Parkinson Disease Type 2

Chromosome 6-Linked Autosomal Recessive Parkinsonism

Early-Onset Parkinsonism With Diurnal Fluctuation

Parkinsonism Young Adult Onset

Parkinson Disease, Type 2

Parkinsonism, Juvenile

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta NQO2 VGNC VGNC:75500
Bos taurus NQO2 VGNC VGNC:32225
Felis catus NQO2 VGNC VGNC:68506
Canis familiaris NQO2 VGNC VGNC:59138
Mus musculus NQO2 MGD MGI:104513
Rattus norvegicus NQO2 RGD RGD:1303320