NRF1 - nuclear respiratory factor 1 Gene

Homo sapiens

Also known as ALPHA-PAL

Gene ID: 4899 | Gene type: protein coding

About NRF1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:129,611,720-129,757,076 (from NCBI)

This gene has 7 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in ovary (RPKM 7.4), lymph node (RPKM 5.2) and 25 other tissues.

Summary

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

NRF1 Products(4)

mRNA	Protein	Name
NM_001040110.2	NP_001035199.1	nuclear respiratory factor 1 isoform 1
NM_001293163.2	NP_001280092.1	nuclear respiratory factor 1 isoform 2
NM_001293164.2	NP_001280093.1	nuclear respiratory factor 1 isoform 3
NM_005011.5	NP_005002.3	nuclear respiratory factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19674972	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	19674972	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19674972	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16864783	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19674972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRF1 Protein Structure

Nrf1_DNA-bind

Nrf1_activ_bdg

0
100
200
300
400
503 a.a.

Protein Preferred Names

Protein Names

nuclear respiratory factor 1

alpha palindromic-binding protein

NRF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NRF1	Q16656	SP4	Homo sapiens	Q02446	Y2H Array	25416956
Intra	NRF1	Q16656	SP4	Homo sapiens	Q02446	Y2H Prey Pooling	25416956
Intra	NRF1	Q16656	POGZ	Homo sapiens	Q7Z3K3	Y2H Array	25416956
Intra	NRF1	Q16656	POGZ	Homo sapiens	Q7Z3K3	Validated Y2H	25416956
Intra	NRF1	Q16656	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	NRF1	Q16656	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	NRF1	Q16656	FHL2	Homo sapiens	Q14192	Y2H Prey Pooling	25416956
Intra	NRF1	Q16656	FHL2	Homo sapiens	Q14192	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oncocytoma

Oxyphilic Adenoma	Follicular Adenoma, Oxyphilic Cell
Adenoma, Oxyphilic	Hurthle Cell Tumor
Oncocytic Neoplasm

Skin Carcinoma In Situ

Carcinoma In Situ Of Skin

Cutaneous Carcinoma In Situ

Benign Peritoneal Mesothelioma

Mesothelioma Of Peritoneum

Benign Neoplasm Of Mesothelial Tissue Of Peritoneum

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129225	WRR139		99.71%	Unkown
HY-125535	OSU-53		/	Unkown
HY-149127	Rosolutamide		/	Unkown
HY-RS09567	NRF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NRF1	VGNC	VGNC:43966
Rattus norvegicus	NRF1	RGD	RGD:1304603
Macaca mulatta	NRF1	VGNC	VGNC:81731
Mus musculus	NRF1	MGD	MGI:1332235
Felis catus	NRF1	VGNC	VGNC:68563
Bos taurus	NRF1	VGNC	VGNC:32260

Name
Email *

	Sorry, but the email address you supplied was invalid.