ATP5F1B - ATP synthase F1 subunit beta Gene

Homo sapiens

Also known as ATP5B; ATPMB; ATPSB; HUMOP2; HEL-S-271

Gene ID: 506 | Gene type: protein coding

About ATP5F1B

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,638,175-56,645,984 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 713.8), kidney (RPKM 376.0) and 25 other tissues.

Summary

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the Other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

ATP5F1B Products(1)

mRNA	Protein	Name
NM_001686.4	NP_001677.2	ATP synthase subunit beta, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	17643490	GOA
enables angiostatin binding	IPI IPI: Inferred from physical interaction	21106936	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10077593	GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism	IDA IDA: Inferred from direct assay	12110673	GOA
enables proton-transporting ATP synthase activity, rotational mechanism	IMP IMP: Inferred from mutant phenotype	21106936	GOA
enables proton-transporting ATPase activity, rotational mechanism	IMP IMP: Inferred from mutant phenotype	17510399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	17510399	GOA
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	17510399	GOA
involved in positive regulation of blood vessel endothelial cell migration	IGI IGI: Inferred from genetic interaction	21106936	GOA
involved in proton motive force-driven mitochondrial ATP synthesis	IDA IDA: Inferred from direct assay	12110673	GOA
involved in proton transmembrane transport	IMP IMP: Inferred from mutant phenotype	17510399	GOA
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	17510399	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	17510399	GOA
located in membrane	IDA IDA: Inferred from direct assay	21106936	GOA
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	8006588	GOA
located in mitochondrial nucleoid	IDA IDA: Inferred from direct assay	18063578	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	2870059	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10077593	GOA
part of proton-transporting ATP synthase complex	IDA IDA: Inferred from direct assay	12110673	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5F1B Protein Structure

ATP-synt_ab_N

ATP-synt_ab

ATP-synt_ab_C

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

ATP synthase subunit beta, mitochondrial

ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

ATP5F1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP5F1B	P06576	ATPAF1	Homo sapiens	Q5TC12	Anti Tag CoIP	28514442
Intra	ATP5F1B	P06576	ATPAF1	Homo sapiens	Q5TC12	Anti Tag CoIP	33961781
Intra	ATP5F1B	P06576	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
Intra	ATP5F1B	P06576	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	ATP5F1B	P06576	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	ATP5F1B	P06576	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	ATP5F1B	P06576	ATP5F1A	Homo sapiens	P25705	Anti Tag CoIP	33961781
Intra	ATP5F1B	P06576	ATP5F1A	Homo sapiens	P25705	Anti Tag CoIP	28514442
Intra	ATP5F1B	P06576	ATP5F1A	Homo sapiens	P25705	Crosslink	30021884
Intra	ATP5F1B	P06576	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	ATP5F1B	P06576	ATP5IF1	Homo sapiens	Q9UII2	Anti Tag CoIP	28514442
Intra	ATP5F1B	P06576	ATP5PD	Homo sapiens	O75947	Anti Tag CoIP	33961781
Intra	ATP5F1B	P06576	ATP5PD	Homo sapiens	O75947	Crosslink	30021884
Intra	ATP5F1B	P06576	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	ATP5F1B	P06576	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	ATP5F1B	P06576	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATP5F1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71716	ATP5F1B Protein, Human (P.pastoris, His)	P06576 (48A-529S)	≥95%

Related Diseases

Diseases

Alias

Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01203	ATP5F1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATP5F1B	MGD	MGI:107801
Rattus norvegicus	ATP5F1B	RGD	RGD:621368
Bos taurus	ATP5F1B	VGNC	VGNC:26300
Felis catus	ATP5F1B	VGNC	VGNC:83505
Others	ATP5F1B	NCBI

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