ATP5IF1 - ATP synthase inhibitory factor subunit 1 Gene

Homo sapiens

Also known as IP; ATPI; ATPIP; ATPIF1

Gene ID: 93974 | Gene type: protein coding

About ATP5IF1

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,236,124-28,238,100 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 112 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 44.4), colon (RPKM 33.7) and 25 other tissues.

Summary

This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

ATP5IF1 Products(3)

mRNA	Protein	Name
NM_016311.5	NP_057395.1	ATPase inhibitor, mitochondrial isoform 1 precursor
NM_178190.3	NP_835497.1	ATPase inhibitor, mitochondrial isoform 2 precursor
NM_178191.3	NP_835498.1	ATPase inhibitor, mitochondrial isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IDA IDA: Inferred from direct assay	15528193	GOA
enables ATPase inhibitor activity	IDA IDA: Inferred from direct assay	12110673	GOA
enables ATPase inhibitor activity	IMP IMP: Inferred from mutant phenotype	24005319	GOA
enables angiostatin binding	IDA IDA: Inferred from direct assay	15528193	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	21106936	GOA
enables mitochondrial proton-transporting ATP synthase complex binding	IDA IDA: Inferred from direct assay	12110673	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	24005319	GOA
involved in negative regulation of ATP-dependent activity	IMP IMP: Inferred from mutant phenotype	24005319	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	15528193	GOA
involved in negative regulation of hydrolase activity	IDA IDA: Inferred from direct assay	15528193	GOA
involved in positive regulation of proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	24005319	GOA
involved in positive regulation of type 2 mitophagy	IMP IMP: Inferred from mutant phenotype	24005319	GOA
involved in regulation of ATP metabolic process	IMP IMP: Inferred from mutant phenotype	24005319	GOA
involved in regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	24005319	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15528193	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	12110673	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5IF1 Protein Structure

IATP

0
100
106 a.a.

Protein Preferred Names

Protein Names

ATPase inhibitor, mitochondrial

ATP synthase F1 subunit epsilon

ATP5IF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATP5IF1	Q9UII2	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	GRN	Homo sapiens	P28799-2	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	GRN	Homo sapiens	P28799-2	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	GRN	Homo sapiens	P28799-2	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	OSMR	Homo sapiens	Q99650	Confocal	32807793
Intra	ATP5IF1	Q9UII2	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	ATP5F1B	Homo sapiens	P06576	Anti Tag CoIP	33961781
Intra	ATP5IF1	Q9UII2	ATP5F1B	Homo sapiens	P06576	Crosslink	30021884
Intra	ATP5IF1	Q9UII2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ATP5IF1	Q9UII2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	ATP5IF1	Q9UII2	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	ATP5IF1	Q9UII2	A2M	Homo sapiens	P01023	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fallopian Tube Adenocarcinoma

Adenocarcinoma Of The Fallopian Tube

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01202	ATP5F1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01203	ATP5F1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01204	ATP5F1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01205	ATP5F1D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01206	ATP5F1E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01207	ATP5IF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01208	ATP5MC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATP5IF1	MGD	MGI:1196457
Canis familiaris	ATP5IF1	VGNC	VGNC:38292
Felis catus	ATP5IF1	VGNC	VGNC:68724
Macaca mulatta	ATP5IF1	VGNC	VGNC:70192
Rattus norvegicus	ATP5IF1	RGD	RGD:2181

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