PARN - poly(A)-specific ribonuclease Gene

Homo sapiens

Also known as DAN; DKCB6; PFBMFT4

Gene ID: 5073 | Gene type: protein coding

About PARN

Cytogenetic location: 16p13.12 Genomic coordinates (GRCh38): 16:14,435,701-14,630,260 (from NCBI)

This gene has 39 transcripts (splice variants), 1 gene allele, 201 orthologues, 2 paralogues and is associated with 6 phenotypes. Ubiquitous expression in thyroid (RPKM 11.4), testis (RPKM 9.5) and 25 other tissues.

Summary

The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

PARN Products(3)

mRNA	Protein	Name
NM_001134477.3	NP_001127949.1	poly(A)-specific ribonuclease PARN isoform 2
NM_001242992.2	NP_001229921.1	poly(A)-specific ribonuclease PARN isoform 3
NM_002582.4	NP_002573.1	poly(A)-specific ribonuclease PARN isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cation binding	IMP IMP: Inferred from mutant phenotype	15358788	GOA
enables poly(A)-specific ribonuclease activity	IDA IDA: Inferred from direct assay	25049417	GOA
enables poly(A)-specific ribonuclease activity	IMP IMP: Inferred from mutant phenotype	26482878	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14731398	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20932473	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	26482878	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in box H/ACA sno(s)RNA 3'-end processing	IDA IDA: Inferred from direct assay	22442037	GOA
involved in lncRNA processing	IMP IMP: Inferred from mutant phenotype	26482878	GOA
involved in miRNA catabolic process	IDA IDA: Inferred from direct assay	25049417	GOA
involved in poly(A)-dependent snoRNA 3'-end processing	IDA IDA: Inferred from direct assay	22442037	GOA
involved in positive regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	26482878	GOA
involved in regulation of telomerase RNA localization to Cajal body	IMP IMP: Inferred from mutant phenotype	26950371	GOA
involved in telomerase RNA stabilization	IMP IMP: Inferred from mutant phenotype	26482878	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	22442037	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARN Protein Structure

CAF1

RNA_bind

0
100
200
300
400
500
600
639 a.a.

Protein Preferred Names

Protein Names

poly(A)-specific ribonuclease PARN

deadenylating nuclease

PARN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PARN	O95453	NCBP1	Homo sapiens	Q09161	Anti Bait CoIP	20379136
Intra	PARN	O95453	NCBP1	Homo sapiens	Q09161	Pull Down	20379136
Intra	PARN	O95453	BARD1	Homo sapiens	Q99728	Anti Bait CoIP	20379136
Intra	PARN	O95453	BARD1	Homo sapiens	Q99728	Pull Down	20379136
Intra	PARN	O95453	CSTF2	Homo sapiens	P33240	Anti Bait CoIP	20379136

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Dyskeratosis Congenita, Autosomal Recessive 6

DKCB6	Autosomal Recessive Dyskeratosis Congenita 6
Dyskeratosis Congenita, Autosomal Recessive, 6	Dyskeratosis Congenita, Autosomal Recessive, Type 6

Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 4

PFBMFT4	Pulmonary Fibrosis, And/Or Bone Marrow Failure, Telomere-Related, 4
Fibrosis, Pulmonary, And/Or Bone Marrow Failure, Telomere-Related, Type 4

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Hoyeraal Hreidarsson Syndrome

Hoyeraal-Hreidarsson Syndrome	Progressive Pancytopenia-Immunodeficiency-Cerebellar Hypoplasia Syndrome
Cerebellar Hypoplasia With Pancytopenia	Growth Retardation Prenatal With Progressive Pancytopenia And Cerebellar Hypoplasia

Pulmonary Fibrosis

Fibrosis Of Lung

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Rheumatoid Arthritis Interstitial Lung Disease

Rheumatoid Lung

Dyskeratosis Congenita Autosomal Recessive

Autosomal Recessive Dyskeratosis Congenita	Dkcb
Dyskeratosis Congenita, Autosomal Recessive

Pontocerebellar Hypoplasia, Type 7

Pontocerebellar Hypoplasia Type 7	PCH7
Pontocerebellar Hypoplasia-46,Xy Disorder Of Sex Development Syndrome	Pontocerebellar Hypoplasia 7
Hypoplasia, Pontocerebellar, Type 7

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Revesz Syndrome

Exudative Retinopathy With Bone Marrow Failure	DKCA5
Dyskeratosis Congenita, Autosomal Dominant 5	Dyskeratosis Congenita With Bilateral Exudative Retinopathy
Retinopathy-Anemia-Central Nervous System Anomalies Syndrome	Revesz-Debuse Syndrome
Dyskeratosis Congenita, Autosomal Dominant, 5	Revesz Debuse Syndrome

Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome	Diffuse Idiopathic Pulmonary Fibrosis
Idiopathic Fibrosing Alveolitis	Ipf
Idiopathic Interstitial Pneumonias	Idiopathic Interstitial Pneumonia, Not Otherwise Specified
Pulmonary Fibrosis

Nonspecific Interstitial Pneumonia

Nsip	Non-Specific Interstitial Pneumonia
Non-Specific Idiopathic Interstitial Pneumonia	Non-Specific Interstitial Pneumonia Nos

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137817	BCH001	Inhibitor	98.83%	Unkown
HY-158970	Caf1-IN-1	Inhibitor	99.44%	Unkown
HY-RS10046	PARN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PARN	VGNC	VGNC:99534
Mus musculus	PARN	MGD	MGI:1921358
Felis catus	PARN	VGNC	VGNC:107806
Rattus norvegicus	PARN	RGD	RGD:1565449
Canis familiaris	PARN	VGNC	VGNC:53535

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