NCBP1 - nuclear cap binding protein subunit 1 Gene

Homo sapiens

Also known as NCBP; Sto1; CBP80

Gene ID: 4686 | Gene type: protein coding

About NCBP1

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,633,821-97,673,748 (from NCBI)

This gene has 5 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 9.3), lymph node (RPKM 7.9) and 25 other tissues.

Summary

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

NCBP1 Products(5)

mRNA	Protein	Name
NM_001351504.2	NP_001338433.1	nuclear cap-binding protein subunit 1 isoform 2
NM_001351505.2	NP_001338434.1	nuclear cap-binding protein subunit 1 isoform 3
NM_001351506.2	NP_001338435.1	nuclear cap-binding protein subunit 1 isoform 3
NM_001351507.2	NP_001338436.1	nuclear cap-binding protein subunit 1 isoform 4
NM_002486.5	NP_002477.1	nuclear cap-binding protein subunit 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA 7-methylguanosine cap binding	IMP IMP: Inferred from mutant phenotype	23793891	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	11545740	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7478990	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 7-methylguanosine mRNA capping	IDA IDA: Inferred from direct assay	12434151	GOA
involved in RNA catabolic process	IMP IMP: Inferred from mutant phenotype	25578728	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	26382858	GOA
involved in histone mRNA metabolic process	IMP IMP: Inferred from mutant phenotype	17499042	GOA
involved in mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	17190602	GOA
involved in mRNA export from nucleus	IPI IPI: Inferred from physical interaction	21326824	GOA
involved in mRNA metabolic process	IMP IMP: Inferred from mutant phenotype	9342333	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21326824	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	11551508	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	18369367	GOA
involved in positive regulation of RNA binding	IMP IMP: Inferred from mutant phenotype	23793891	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	26382858	GOA
involved in positive regulation of mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	9342333	GOA
involved in positive regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	23793891	GOA
involved in regulation of translational initiation	IDA IDA: Inferred from direct assay	11551508	GOA
involved in snRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	26382858	GOA
involved in spliceosomal complex assembly	IMP IMP: Inferred from mutant phenotype	23793891	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA cap binding complex	IMP IMP: Inferred from mutant phenotype	23793891	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	26382858	GOA
part of nuclear cap binding complex	IDA IDA: Inferred from direct assay	7651522	GOA
part of nuclear cap binding complex	IPI IPI: Inferred from physical interaction	8069914	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8069914	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCBP1 Protein Structure

MIF4G

MIF4G_like

MIF4G_like_2

0
200
400
600
790 a.a.

Protein Preferred Names

Protein Names

nuclear cap-binding protein subunit 1

80 kDa nuclear cap-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09072	NCBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCBP1	RGD	RGD:1308973
Mus musculus	NCBP1	MGD	MGI:1891840
Felis catus	NCBP1	VGNC	VGNC:68423
Bos taurus	NCBP1	VGNC	VGNC:31907
Canis familiaris	NCBP1	VGNC	VGNC:43645
Macaca mulatta	NCBP1	VGNC	VGNC:75138

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