NCBP1 - nuclear cap binding protein subunit 1 Gene

Homo sapiens

Also known as NCBP; Sto1; CBP80

Gene ID: 4686 | Gene type: protein coding

About NCBP1

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,633,821-97,673,748 (from NCBI)

This gene has 5 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 9.3), lymph node (RPKM 7.9) and 25 other tissues.

Summary

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]

NCBP1 Products(5)

mRNA	Protein	Name
NM_001351504.2	NP_001338433.1	nuclear cap-binding protein subunit 1 isoform 2
NM_001351505.2	NP_001338434.1	nuclear cap-binding protein subunit 1 isoform 3
NM_001351506.2	NP_001338435.1	nuclear cap-binding protein subunit 1 isoform 3
NM_001351507.2	NP_001338436.1	nuclear cap-binding protein subunit 1 isoform 4
NM_002486.5	NP_002477.1	nuclear cap-binding protein subunit 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA 7-methylguanosine cap binding	IMP IMP: Inferred from mutant phenotype	23793891	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	11545740	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7478990	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 7-methylguanosine mRNA capping	IDA IDA: Inferred from direct assay	12434151	GOA
involved in RNA catabolic process	IMP IMP: Inferred from mutant phenotype	25578728	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	26382858	GOA
involved in histone mRNA metabolic process	IMP IMP: Inferred from mutant phenotype	17499042	GOA
involved in mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	17190602	GOA
involved in mRNA export from nucleus	IPI IPI: Inferred from physical interaction	21326824	GOA
involved in mRNA metabolic process	IMP IMP: Inferred from mutant phenotype	9342333	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21326824	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	11551508	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	18369367	GOA
involved in positive regulation of RNA binding	IMP IMP: Inferred from mutant phenotype	23793891	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	26382858	GOA
involved in positive regulation of mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	9342333	GOA
involved in positive regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	23793891	GOA
involved in regulation of translational initiation	IDA IDA: Inferred from direct assay	11551508	GOA
involved in snRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	26382858	GOA
involved in spliceosomal complex assembly	IMP IMP: Inferred from mutant phenotype	23793891	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA cap binding complex	IMP IMP: Inferred from mutant phenotype	23793891	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	26382858	GOA
part of nuclear cap binding complex	IDA IDA: Inferred from direct assay	7651522	GOA
part of nuclear cap binding complex	IPI IPI: Inferred from physical interaction	8069914	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8069914	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCBP1 Protein Structure

MIF4G

MIF4G_like

MIF4G_like_2

0
200
400
600
790 a.a.

Protein Preferred Names

Protein Names

nuclear cap-binding protein subunit 1

80 kDa nuclear cap-binding protein

NCBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NCBP1	Q09161	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	NCBP1	Q09161	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Comig Non-Denat Gel	19668212
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Pull Down	19668212
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Anti Tag CoIP	19668212
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	Anti Bait CoIP	23665581
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298-1	GMS	19668212
Intra	NCBP1	Q09161	POLDIP3	Homo sapiens	Q9BY77	Anti Tag CoIP	18423201
Intra	NCBP1	Q09161	RNF20	Homo sapiens	Q5VTR2	Validated Y2H	32296183
Intra	NCBP1	Q09161	RNF20	Homo sapiens	Q5VTR2	Y2H Array	32296183
Intra	NCBP1	Q09161	RNF20	Homo sapiens	Q5VTR2	Y2H Prey Pooling	32296183
Intra	NCBP1	Q09161	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	NCBP1	Q09161	RPS6	Homo sapiens	P62753	Anti Tag CoIP	18423201
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	X-Ray Diffraction	11545740
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Y2H	22365833
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	X-Ray Diffraction	12374755
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	BRET	29997244
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	SLC	31467278
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	X-Ray Diffraction	12434151
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Anti Tag CoIP	26496610
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Crosslink	29101316
Intra	NCBP1	Q09161	NCBP2	Homo sapiens	P52298	Lumier	29997244
Intra	NCBP1	Q09161	NCBP3	Homo sapiens	Q53F19	Y2H	22365833
Intra	NCBP1	Q09161	NCBP3	Homo sapiens	Q53F19	Anti Tag CoIP	32960270
Intra	NCBP1	Q09161	RNF40	Homo sapiens	O75150	Y2H Prey Pooling	32296183
Intra	NCBP1	Q09161	RNF40	Homo sapiens	O75150	Y2H Array	32296183
Intra	NCBP1	Q09161	RNF40	Homo sapiens	O75150	Y2H Pooling	16189514
Intra	NCBP1	Q09161	PABPC1	Homo sapiens	P11940	Anti Bait CoIP	23665581
Intra	NCBP1	Q09161	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	32960270

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09072	NCBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCBP1	RGD	RGD:1308973
Mus musculus	NCBP1	MGD	MGI:1891840
Felis catus	NCBP1	VGNC	VGNC:68423
Bos taurus	NCBP1	VGNC	VGNC:31907
Canis familiaris	NCBP1	VGNC	VGNC:43645
Macaca mulatta	NCBP1	VGNC	VGNC:75138

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