Fbxl3 - F-box and leucine-rich repeat protein 3 Gene

Mus musculus

Also known as FBK; Ovtm; Fbl3a; Fbxl3a; Play68

Gene ID: 50789 | Gene type: protein coding

About Fbxl3

Summary

Contributes to ubiquitin-protein transferase activity. Involved in cellular protein metabolic process; entrainment of circadian clock by photoperiod; and protein destabilization. Located in cytosol and nucleus. Is expressed in embryo; extraembryonic component; inner cell mass; and trophectoderm. Orthologous to human FBXL3 (F-box and leucine rich repeat protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Fbxl3 Products(5)

mRNA	Protein	Name
NM_001347600.1	NP_001334529.1	F-box/LRR-repeat protein 3 isoform 2
NM_001347601.1	NP_001334530.1	F-box/LRR-repeat protein 3 isoform 2
NM_001360341.1	NP_001347270.1	F-box/LRR-repeat protein 3 isoform 1
NM_001360342.1	NP_001347271.1	F-box/LRR-repeat protein 3 isoform 1
NM_015822.3	NP_056637.1	F-box/LRR-repeat protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17462724	MGI
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17462724	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23452855	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	23452855	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	17462724	MGI
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	23616524	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	23452855	MGI
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	26776516	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	17462724	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	23452855	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17463252	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

F-box/LRR-repeat protein 3

F-box and leucine-rich repeat protein 3a	F-box/LRR-repeat protein 3A
protein after-hours	protein overtime

Fbxl3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fbxl3	Q8C4V4	Cry1	Mus musculus	P97784	Anti Tag CoIP	23452855
Intra	Fbxl3	Q8C4V4	Cry1	Mus musculus	P97784	Anti Tag CoIP	17462724
Intra	Fbxl3	Q8C4V4	Cry1	Mus musculus	P97784	Anti Tag CoIP	23452856
Intra	Fbxl3	Q8C4V4	Cry2	Mus musculus	Q9R194	Anti Tag CoIP	17462724
Intra	Fbxl3	Q8C4V4	Cry2	Mus musculus	Q9R194	Anti Tag CoIP	23452856
Intra	Fbxl3	Q8C4V4	Per2	Mus musculus	O54943	Anti Tag CoIP	23452855
Cross	Fbxl3	Q8C4V4	SKP1	Homo sapiens	P63208	Anti Tag CoIP	23452856
Cross	Fbxl3	Q8C4V4	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	23452856
Cross	Fbxl3	Q8C4V4	CUL1	Homo sapiens	Q13616	BiFC	23452855

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134194	KL201		98.15%	Unkown
HY-RS04791	FBXL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fbxl3	NCBI	NCBI:26224

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