Cry1 - cryptochrome 1 (photolyase-like) Gene

Mus musculus

Also known as Phll1

Gene ID: 12952 | Gene type: protein coding

About Cry1

Summary

This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across Plants and Animals. Loss of this gene results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]

Cry1 Products(1)

mRNA	Protein	Name
NM_007771.3	NP_031797.1	cryptochrome-1

Protein Preferred Names

Protein Names

cryptochrome-1

Cry1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cry1	P97784	Fbxl3	Mus musculus	Q8C4V4	BiFC	23452855
Intra	Cry1	P97784	Fbxl3	Mus musculus	Q8C4V4	Anti Tag CoIP	23452855
Intra	Cry1	P97784	Fbxl3	Mus musculus	Q8C4V4	Anti Tag CoIP	23452856
Intra	Cry1	P97784	Fbxl3	Mus musculus	Q8C4V4	Anti Tag CoIP	17462724
Intra	Cry1	P97784	Per2	Mus musculus	O54943	Fluorescence	24855952
Intra	Cry1	P97784	Per2	Mus musculus	O54943	Chromatography	24855952
Intra	Cry1	P97784	Per2	Mus musculus	O54943	Anti Tag CoIP	22170608
Intra	Cry1	P97784	Per2	Mus musculus	O54943	ITC	24855952
Intra	Cry1	P97784	Per2	Mus musculus	O54943	Comig Non-Denat Gel	24855952
Intra	Cry1	P97784	Per2	Mus musculus	O54943	CD	24855952
Intra	Cry1	P97784	Per2	Mus musculus	O54943	Y2H	24737000
Intra	Cry1	P97784	Per2	Mus musculus	O54943	Anti Tag CoIP	23452855
Intra	Cry1	P97784	Per2	Mus musculus	O54943	Biophysical	24855952
Intra	Cry1	P97784	Nr3c1	Mus musculus	P06537-1	Anti Tag CoIP	22170608
Intra	Cry1	P97784	Bmal1	Mus musculus	Q9WTL8	Y2H	24737000
Intra	Cry1	P97784	Bmal1	Mus musculus	Q9WTL8	Gal4 VP16 Complement	18430226
Intra	Cry1	P97784	Bmal1	Mus musculus	Q9WTL8	Anti Tag CoIP	16777965
Intra	Cry1	P97784	Bmal1	Mus musculus	Q9WTL8-2	Gal4 VP16 Complement	18430226
Intra	Cry1	P97784	Bmal1	Mus musculus	Q9WTL8-2	Anti Tag CoIP	18075593
Intra	Cry1	P97784	Bmal1	Mus musculus	Q9WTL8-4	Anti Tag CoIP	25961797
Intra	Cry1	P97784	Fbxl21	Mus musculus	Q8BFZ4	Anti Tag CoIP	23452856
Intra	Cry1	P97784	Fbxl21	Mus musculus	Q8BFZ4	BiFC	23452855
Intra	Cry1	P97784	Fbxl21	Mus musculus	Q8BFZ4	Anti Tag CoIP	23452855
Intra	Cry1	P97784	Clock	Mus musculus	O08785	Anti Tag CoIP	25961797
Intra	Cry1	P97784	Clock	Mus musculus	O08785	Y2H	23555304
Intra	Cry1	P97784	Clock	Mus musculus	O08785	Anti Tag CoIP	18075593
Intra	Cry1	P97784	Clock	Mus musculus	O08785	Anti Tag CoIP	16777965
Intra	Cry1	P97784	Bmal2	Mus musculus	Q2VPD4	NMR	25961797
Intra	Cry1	P97784	Bmal2	Mus musculus	Q2VPD4	ITC	25961797
Intra	Cry1	P97784	Bmal2	Mus musculus	Q2VPD4	FPS	25961797

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108468	KL001		99.68%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115672	KS15		99.40%	Unkown
HY-134194	KL201		98.15%	Unkown
HY-148764	M47	Inducer	99.90%	Unkown
HY-RS03204	CRY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cry1	NCBI	NCBI:1407

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