2. Gene
  3. ASAP1 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Gene

ASAP1 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAP; PAG2; AMAP1; DDEF1; ZG14P; CENTB4

Gene ID: 50807 | Gene type: protein coding

About ASAP1

Cytogenetic location: 8q24.21-q24.22 Genomic coordinates (GRCh38): 8:130,052,104-130,443,674 (from NCBI)

This gene has 16 transcripts (splice variants), 240 orthologues and 28 paralogues. Ubiquitous expression in bone marrow (RPKM 18.3), spleen (RPKM 15.5) and 24 other tissues.

Summary

This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and Cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

ASAP1 Products(5)

mRNA Protein Name
NM_001247996.2 NP_001234925.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
NM_001362924.1 NP_001349853.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3
NM_001362925.2 NP_001349854.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4
NM_001362926.2 NP_001349855.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5
NM_018482.4 NP_060952.2 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12029088 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
20393563 GOA
involved in protein localization to cilium IDA
IDA: Inferred from direct assay
25673879 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
25673879 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
25673879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASAP1 Protein Structure

PH

PH: PH domain (326 - 414)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (440 - 555)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (585 - 666)

SH3_1

SH3_1: SH3 domain (1074 - 1121)

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  • 1129 a.a.
Protein Preferred Names Protein Names

arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein

ASAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ASAP1 Q9ULH1 HCK Homo sapiens P08631
Pull Down
12029088
Intra
ASAP1 Q9ULH1 HCK Homo sapiens P08631
ELISA
16636290
Intra
ASAP1 Q9ULH1 SH3KBP1 Homo sapiens Q96B97
Anti Bait CoIP
17255943
Intra
ASAP1 Q9ULH1 SH3KBP1 Homo sapiens Q96B97
Imaging
17255943
Intra
ASAP1 Q9ULH1 SH3KBP1 Homo sapiens Q96B97
Pull Down
17255943
Intra
ASAP1 Q9ULH1 SH3KBP1 Homo sapiens Q96B97
Anti Tag CoIP
15090612
Intra
ASAP1 Q9ULH1 CTTN Homo sapiens Q14247
X-Ray Diffraction
16636290
Intra
ASAP1 Q9ULH1 CTTN Homo sapiens Q14247
Pull Down
17255943
Intra
ASAP1 Q9ULH1 NCK1 Homo sapiens P16333
ELISA
16636290
Intra
ASAP1 Q9ULH1 FYN Homo sapiens P06241
ELISA
16636290
Intra
ASAP1 Q9ULH1 SRC Homo sapiens P12931
Peptide Array
17474147
Intra
ASAP1 Q9ULH1 SRC Homo sapiens P12931
ELISA
16636290
Intra
ASAP1 Q9ULH1 CBLB Homo sapiens Q13191
Anti Bait CoIP
17255943
Intra
ASAP1 Q9ULH1 PLCG1 Homo sapiens P19174
Fluorescence
17474147
Intra
ASAP1 Q9ULH1 PLCG1 Homo sapiens P19174
Peptide Array
17474147
Cross
ASAP1 Q9ULH1 apc Crosspus laevis P70039
Pull Down
18786926
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Laryngeal Benign Neoplasm

Laryngeal Tumor

Larynx Neoplasm

Neoplasm Of Larynx

Laryngeal Cancer

Laryngeal Carcinoma

Cancer Of Larynx
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01055 ASAP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ASAP1 VGNC VGNC:59952
Mus musculus ASAP1 MGD MGI:1342335
Rattus norvegicus ASAP1 RGD RGD:1307379
Macaca mulatta ASAP1 VGNC VGNC:69918
Canis familiaris ASAP1 VGNC VGNC:38153
Bos taurus ASAP1 VGNC VGNC:26184