TXNDC12 - thioredoxin domain containing 12 Gene

Homo sapiens

Also known as AG1; AGR1; ERP16; ERP18; ERP19; TLP19; hAG-1; PDIA16; hTLP19

Gene ID: 51060 | Gene type: protein coding

About TXNDC12

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,020,131-52,056,171 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 12.7), thyroid (RPKM 11.7) and 25 other tissues.

Summary

This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]

TXNDC12 Products(1)

mRNA	Protein	Name
NM_015913.4	NP_056997.1	thioredoxin domain-containing protein 12 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein-disulfide reductase (glutathione) activity	IDA IDA: Inferred from direct assay	12761212	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	18628206	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	18628206	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	12761212	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXNDC12 Protein Structure

Thioredoxin_7

0
100
172 a.a.

Protein Preferred Names

Protein Names

thioredoxin domain-containing protein 12

ER protein 18

Recombinant TXNDC12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71046	TXNDC12 Protein, Human (HEK293, His)	O95881 (H27-L168)	≥95%

Related Diseases

Diseases

Alias

Discitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15290	TXNDC12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TXNDC12	VGNC	VGNC:48011
Felis catus	TXNDC12	VGNC	VGNC:66725
Bos taurus	TXNDC12	VGNC	VGNC:36535
Rattus norvegicus	TXNDC12	RGD	RGD:1305960
Mus musculus	TXNDC12	MGD	MGI:1913323
Others	TXNDC12	NCBI

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