CAMLG - calcium modulating ligand Gene

Homo sapiens

Also known as CAML; GET2

Gene ID: 819 | Gene type: protein coding

About CAMLG

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,738,548-134,752,157 (from NCBI)

This gene has 9 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 22.3), ovary (RPKM 21.6) and 25 other tissues.

Summary

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to Cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate Calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to Cyclophilin B and acting downstream of the TCR and upstream of Calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating Cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

CAMLG Products(1)

mRNA	Protein	Name
NM_001745.4	NP_001736.1	guided entry of tail-anchored proteins factor CAMLG

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15451437	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	20553626	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	20553626	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	20553626	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	32187542	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20553626	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IDA IDA: Inferred from direct assay	27226539	GOA
involved in tail-anchored membrane protein insertion into ER membrane	IMP IMP: Inferred from mutant phenotype	23041287	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of GET complex	IDA IDA: Inferred from direct assay	32910895	GOA
part of GET complex	IPI IPI: Inferred from physical interaction	23041287	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20553626	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12919676	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	31417168	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMLG Protein Structure

CAML

0
100
200
296 a.a.

Protein Preferred Names

Protein Names

guided entry of tail-anchored proteins factor CAMLG

calcium signal-modulating cyclophilin ligand

Related Diseases

Diseases

Alias

Epstein-Barr Virus Hepatitis

Achilles Bursitis

Achilles Bursitis Or Tendinitis	Capped Hock
Haglund'S Deformity	Haglund'S Disease
Osteochondritis Of The Talus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01869	CAMLG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CAMLG	VGNC	VGNC:110479
Canis familiaris	CAMLG	VGNC	VGNC:38687
Mus musculus	CAMLG	MGD	MGI:104728
Bos taurus	CAMLG	VGNC	VGNC:26729
Rattus norvegicus	CAMLG	RGD	RGD:69297
Felis catus	CAMLG	VGNC	VGNC:60339

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