2. Gene
  3. CAMLG - calcium modulating ligand Gene

CAMLG - calcium modulating ligand Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAML; GET2

Gene ID: 819 | Gene type: protein coding

About CAMLG

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,738,548-134,752,157 (from NCBI)

This gene has 9 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 22.3), ovary (RPKM 21.6) and 25 other tissues.

Summary

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to Cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate Calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to Cyclophilin B and acting downstream of the TCR and upstream of Calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating Cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

CAMLG Products(1)

mRNA Protein Name
NM_001745.4 NP_001736.1 guided entry of tail-anchored proteins factor CAMLG
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15451437 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
20553626 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
20553626 GOA
involved in negative regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
20553626 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
32187542 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20553626 GOA
involved in tail-anchored membrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
27226539 GOA
involved in tail-anchored membrane protein insertion into ER membrane IMP
IMP: Inferred from mutant phenotype
23041287 GOA
Cellular Component GO Annotation Evidence Reference Source
part of GET complex IDA
IDA: Inferred from direct assay
32910895 GOA
part of GET complex IPI
IPI: Inferred from physical interaction
23041287 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20553626 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
12919676 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
31417168 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMLG Protein Structure

CAML

CAML: Calcium signal-modulating cyclophilin ligand (23 - 292)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

guided entry of tail-anchored proteins factor CAMLG

calcium signal-modulating cyclophilin ligand

CAMLG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CAMLG P49069 KCNA2 Homo sapiens P16389
Validated Y2H
25416956
Intra
CAMLG P49069 KCNA2 Homo sapiens P16389
Y2H Prey Pooling
25416956
Intra
CAMLG P49069 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
Intra
CAMLG P49069 KCNE4 Homo sapiens Q8WWG9
Validated Y2H
32296183
Intra
CAMLG P49069 LCN2 Homo sapiens P80188
Validated Y2H
32296183
Intra
CAMLG P49069 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra
CAMLG P49069 VWC2 Homo sapiens Q2TAL6
Validated Y2H
32296183
Intra
CAMLG P49069 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra
CAMLG P49069 KCNA2 Homo sapiens P16389-2
Y2H Prey Pooling
32296183
Intra
CAMLG P49069 KCNA2 Homo sapiens P16389-2
Y2H Array
32296183
Intra
CAMLG P49069 HSP90B1 Homo sapiens Q96GW1
Validated Y2H
32296183
Intra
CAMLG P49069 IER3 Homo sapiens P46695
Y2H
15451437
Intra
CAMLG P49069 IER3 Homo sapiens P46695
Anti Bait CoIP
15451437
Intra
CAMLG P49069 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra
CAMLG P49069 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra
CAMLG P49069 GET3 Homo sapiens O43681
Anti Tag CoIP
33961781
Intra
CAMLG P49069 GET3 Homo sapiens O43681
Anti Tag CoIP
28514442
Cross
CAMLG P49069 NS7b Human SARS coronavirus Q7T6S2
Lumier
22046132
Cross
CAMLG P49069 NS7b Human SARS coronavirus Q7T6S2
Y2H Pooling
22046132
Intra
CAMLG P49069 OCIAD1 Homo sapiens Q9NX40
Validated Y2H
32296183
Intra
CAMLG P49069 OCIAD1 Homo sapiens Q9NX40
Y2H Array
32296183
Intra
CAMLG P49069 OCIAD1 Homo sapiens Q9NX40
Y2H Prey Pooling
32296183
Intra
CAMLG P49069 ETNK1 Homo sapiens Q9HBU6
Validated Y2H
32296183
Intra
CAMLG P49069 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
CAMLG P49069 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
CAMLG P49069 PBXIP1 Homo sapiens Q96AQ6
Validated Y2H
32296183
Intra
CAMLG P49069 F11R Homo sapiens Q9Y624
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

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Haglund'S Disease

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Diseases Alias
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Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01869 CAMLG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CAMLG VGNC VGNC:110479
Canis familiaris CAMLG VGNC VGNC:38687
Mus musculus CAMLG MGD MGI:104728
Bos taurus CAMLG VGNC VGNC:26729
Rattus norvegicus CAMLG RGD RGD:69297
Felis catus CAMLG VGNC VGNC:60339